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OBJECTIVES: To report the long-term safety and efficacy of BAY 81-8973 in the LEOPOLD Kids extension phase.METHODS: Patients received BAY 81-8973 (25-50 IU/kg) at least twice weekly. The primary endpoint was safety, assessed in all patients who entered the extension phase (n = 82). Efficacy endpoints were assessed in patients without high-titre inhibitors/immune tolerance induction (n = 67).RESULT

Objectives To follow up four previously identified classes 'pure axial spondyloarthritis' (axSpA) ('axial'), 'axSpA with peripheral signs' ('inflammatory back pain+peripheral'), 'axSpA at risk' and 'no spondyloarthritis' ('no SpA'). They reflect the expert-opinion-free construct or 'Gestalt' of chronic back pain suspicious of axSpA. The aim was to assess participants' transitions between these cla

Climate and land use changes can increase terrestrial runoff to aquatic systems, leading to brownification and eutrophication in northern boreal lakes. Brownification may boost bacterial respiration and production, while eutrophication can enhance primary production and algal blooms. However, their combined effects on basal producers and bacterial carbon utilization are less understood. This study

Sweden is exporting military products and services to Saudi Arabia. Such trade can be seen as any other business, but various moral aspects could be considered to justify or condemn military export. Inspired by content and idea analysis, an investigative scheme with nine features was constructed to display the principal question of moral bearing on military export by evaluating the debate abou

I en intervju med publicisten Ken Tyler så beskrev den amerikanska efterkrigskonstnären och abstraktionisten Helen Frankenthaler uppfinnarskapet som en regellös aktivitet: “Så föds konsten, på det sättet sker genombrott. Bryt mot reglerna eller ignorera dem. Det är vad uppfinnarskap handlar om.” Jämfört med juridikens precisa och noggranna metodik så framstår uppfinnandets skapande metod något anThe U.S. painter Helen Frankenthaler, a behemoth of post-war American abstractionist painting, once described the act of inventing as an activity without rules. ”This is how art is born, how breakthroughs happen. Go against the rules or ignore the rules. That is what invention is about”, she is quoted saying in a 1994 interview with legendary publisher Ken Tyler. In contrast with the precise and

Three NUP98 chimaeras have previously been reported in T cell acute lymphoblastic leukaemia (T-ALL): NUP98/ADD3, NUP98/CCDC28A, and NUP98/RAP1GDS1. We report a T-ALL with t(11;18)(p15;q12) resulting in a novel NUP98 fusion. Fluorescent in situ hybridisation showed NUP98 and SET binding protein 1(SETBP1) fusion signals; other analyses showed that exon 12 of NUP98 was fused in-frame with exon 5 of S

AIM: To examine treatment and glucose control in type 2 diabetes patients with and without hypertension, and to explore differences in markers for insulin resistance and beta cell function. METHODS: A community-based, cross-sectional observational study was carried out at the hypertension and diabetes outpatient clinic in primary health care, Skara, Sweden. The subjects were all the 400 patients w

Substitution of fossil transport fuels with biodiesel and bioethanol can lower greenhouse gas emissions, reduce dependency on oil and strengthen agriculture. This thesis describes, compares and analyses market penetration of biodiesel and bioethanol, as well as the socio-political context for biofuels, in Germany and the United Kingdom. General conclusions for policy makers wanting to design or ch

Viktor Orbán’s FIDESZ is often referred to in academia as a right-wing populist political party. However, stemming from Hungary’s history of being dominated by outside powers and having been under communist rule for fifty years, this thesis argues that the nature of FIDESZ’s communication strategy could be heavily influenced by left-wing populist ideals. This thesis seeks to investigate populist a

The purpose of this paper is to gain an understanding into how a neoliberal environmentalist norm-complex can be used to understand the Swedish climate action plans published in 2019 and 2023. This was done through a mixed method approach, where the qualitative stage was allowed to take the most place. The quantitative stage of the analysis showed that the normative element of Green growth and sus

Artificial intelligence (AI) applications change the labour market for human workers. To establish if the applications are determined positive or not, they must be researched in a specified field. One field that is affected by AI applications is the field of economics. In this study, the anxiety towards AI and organisation-based self-esteem (OBSE) in (N = 79) accountants, auditors, and payroll cle

This research builds on the assertion that spirituality can be beneficial to human-wellbeing and in creating nature-connection. Applying that notion within the historical context of Christianity and its ties to the work-ethics of capitalism, the paper presents a case-study of the Threeclover Church, a Protestant Green Church in Denmark’s capital region. The aim is to gain further understanding of

With the projection of a growing amount of waste from photovoltaic (PV) panels in coming years, experts and researchers have highlighted the importance of the circular economy approach to face this challenge. With this approach, risks linked to the composition of PV panels, such as pollution and wastage of valuable materials, can be reduced. Therefore, this thesis aims to provide a systematic view

Central venous catheter misplacement is common (approximately 7%) after right subclavian vein catheterisation. To avoid it, ultrasound-guided tip navigation may be used during the catheterisation procedure to help direct the guidewire towards the lower superior vena cava. We aimed to determine the number of central venous catheter misplacements when using the right supraclavicular fossa ultrasound

The Child Behavior Checklist (CBCL) and Youth Self-Report (YSR) are widely used measures of psychiatric symptoms and lately also adapted to the DSM. The incremental validity of adding the scales to each other has not been studied. We validated the DSM subscales for affective, anxiety, attention deficit/hyperactivity (ADHD), oppositional defiant (ODD), conduct problems (CD), and obsessive-compulsiv

Background: The inverse observational association between body mass index (BMI) and lung cancer risk remains unclear. We assessed whether the association is explained by metabolic aberrations, residual confounding, and within-person variability in smoking, and compared against other smoking-related cancers. Methods: We investigated the association between BMI, and its combination with a metabolic

This study demonstrates the use of a photoelectrochemical device comprising earth-abundant hematite photoanode for the oxidation of 5-hydroxymethylfurfural (5-HMF), a versatile bio-based platform chemical, under ambient conditions in the presence of an electron mediator. The results obtained in this study showed that the hematite photoanode, upon doping with fluorine, can oxidize water even at low