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Protein drugs, such as monoclonal antibodies, have proved successful in treating cancer and immune system diseases. The structural complexity of these molecules requires careful handling to ensure integrity and stability of the drug. In this study, a failure mode and effects analysis was performed based on a Gemba Walk method in a Swedish University Hospital. The Gemba Walk is focused on pharmacis

Microglia have an innate immunity memory (IIM) with divergent functions in different animal models of neurodegenerative diseases, including Alzheimer's disease (AD). AD is characterized by chronic neuroinflammation, neurodegeneration, tau tangles and β-amyloid (Aβ) deposition. Systemic inflammation has been implicated in contributing to the progression of AD. Multiple reports have demonstrated uni

INTRODUCTION: Height, body mass index (BMI), and weight gain are associated with breast cancer risk in the general population. It is unclear whether these associations also exist for carriers of pathogenic variants in the BRCA1 or BRCA2 genes.PATIENTS AND METHODS: An international pooled cohort of 8091 BRCA1/2 variant carriers was used for retrospective and prospective analyses separately for prem

Popular Abstract in Swedish Syftet med den här licentiatuppsatsen är dels att beskriva äldre människors intresse av och möjligheter till att använda TV:n till annat än traditionellt TV-tittande, dels att beskriva olineariteterna i den designprocess i vilken detta arbete ägde rum. Konceptet ”Den utsträckta TV:n” utvecklades och provades (av äldre människor, deras anhöriga och personal) i en ny våThe aim of this licentiate thesis is twofold: 1) to describe old people’s interest in and prospects of using the television for something other than traditional TV viewing, and 2) to describe the nonlinearities in the design process in which this research was performed. A concept called The Extended TV was developed and tested (by old people, their relatives and care workers) in a new nursing home

A genomic cosmid clone for human sex hormone binding globulin (SHBG), a liver-secreted plasma glycoprotein that binds sex steroids, was isolated with a previously characterized liver cDNA as probe. Southern blot analysis of genomic DNA indicated that only one SHBG gene is present in the human haploid genome. A 3.8 Kb Xba I-fragment of the clone containing the entire coding region of SHBG was seque

Popular Abstract in Swedish Det finns flera avancerade datormodeller att tillgå för att analysera och utvärdera brandsäkerheten i byggnader i samband med nyproduktion och ombyggnad. Denna typ av datormodeller kan, i många fall, göra bra förutsägelser av faktorer som är betydelsefulla för brandsäkerheten och därför är de viktiga verktyg vid brandtekniska analyser. Datormodellerna är dock komplexa oFire dynamics in multi-room compartments are explored in this thesis and new methods to study conditions in rooms adjacent to the room of fire origin are presented. Simple and transparent engineering methods can create good possibilities for understanding different complex phenomena present in fire science. Such methods can also be used in the design process in order to perform rough estimates bef

Extended producer responsibility (EPR) is a concept from Industrial Ecology that has changed waste management policies inside and gradually outside the member countries of the Organisation for Economic Co-operation and Development (OECD). This article bridges the gap in our understanding of the policy process wherein policy change occurred. It employs the Advocacy Coalition Framework (ACF) to expl

Research focus in environmental pollution has recently been extended from more classical environmental pollutants such as PCBs or pesticides to pharmaceuticals and steroid hormones, which are designed to be biologically active and enter the environment primarily through regular domestic use. Consequently, it is important to monitor these substances concentrations in the effluents of sewage treatme

BACKGROUND: The Swedish school-based vaccination programme offers HPV vaccine to girls born ≥1999 in 5-6th grade. In 2012, all counties introduced free-of-charge catch-up vaccination campaigns targeting girls born 1993-1998. Varying vaccine uptake in the catch-up group by December 2012 suggested that some implementation strategies were more successful than others. In order to inform future vaccina

To produce sufficient amounts of recombinant catechol-O-methyltransferase (COMT) for structural and functional studies the coding regions of the rat liver and human placental COMT genes have been introduced into a bacterial expression vector pKEX14. Recombinant COMT was produced in Escherichia coli up to 10% of total bacterial protein after the induction of the T7 RNA polymerase gene with isopropy

We addressed whether endothelin-1, a marker of endothelial dysfunction, predicts impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) in a population study in south-western Sweden. Follow-up after 9.7 years showed an association between circulating endothelin-1 levels at baseline and development of IGT/T2DM in women but not in men.

A virgin ant queen has only one opportunity in her lifetime to realize her reproductive fitness when she leaves her nest for a mating flight. After successful mating she sheds her wings, excavates a nest and starts laying eggs to initiate her own colony. Here we report the results of our study on two related species of Camponotus ants - day active Camponotus paria and night active Camponotus compr

The study of public transport and tourism, especially domestic tourism, is relatively under-researched, particularly in relation to emerging transport technologies, such as artificial intelligence (AI), and environmental, social, and governance (ESG). To bridge this gap, an integrated research model is created and tested with ESG, air quality, climate change, and AI, applying multi-analysis method

Differential and double-differential distributions of kinematic variables of leptons from decays of top-quark pairs (tt¯) are measured using the full LHC Run 2 data sample collected with the ATLAS detector. The data were collected at a pp collision energy of s = 13 TeV and correspond to an integrated luminosity of 140 fb −1. The measurements use events containing an oppositely charged eμ pair and