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Popular Abstract in Swedish Ärfltiga faktorer orsakar ledgångsreumatism Reumatoid artrit (RA) även kallat ledgångsreumatism är en ledsjukdom som drabbar 1% av befolkningen, framförallt kvinnor. Orsaken till sjukdommen är inte känd, men man tror att det finns en ärftlig faktor som avgör om en viss individ kan utveckla reumatoid artrit eller inte. Den genetiskassociationen man idag vet om är till mThe immune pathology and MHC association of chronic arthritis was studied in three rat models for reumatoid arthritis (RA). Susceptible rat strains develop a T cell dependent chronic disease after immunization with rat collagen type II (CII). The LEW rat does not develop arthritis after immunization with rat CII, but a heterologous immune response to pepsin can break the tolerance to CII and rende

Popular Abstract in Swedish Denna avhandling är uppbyggd kring fyra artiklar som berör reglering av gener i B-celler. B-cellerna är en viktig del av vårt immunförsvar, de sköter produktionen av antikroppar som hjälper till att skydda våra slemhinnor och vårt inre från sjukdomsframkallande bakterier och virus. Kroppens försvar mot sådana patogener består av flera delar, inklusive vår hud och våra sEach Ig V-region has its own upstream promoter and the promoter of a mature Ig gene is thereby selected during the V(D)J recombination process. Upon comparison, it is evident that only one transcription factor binding site, the octamer, is preserved within all promoters. The octamer motif and the binding Oct-proteins are crucial for Ig promoter function, but not sufficient for a high level of tran

Popular Abstract in Swedish Årligen diagnostiseras cirka 60 000 nya fall av cancer i Sverige (Socialstyrelsen, 2015), och var tredje person beräknas få en cancerdiagnos under sin livstid. Trots stora framsteg inom forskning och utveckling är cancer, näst efter hjärt- och kärlsjukdomar, den vanligaste dödsorsaken i vårt samhälle. Bland de tio vanligaste formerna av cancer hör lymfom, vilket är etMantle cell lymphoma (MCL) is an aggressive form of B-cell lymphoma (BCL) with poor clinical outcome. In this thesis, which is based upon five original papers, different approaches have been used to pinpoint and investigate molecular events that promote MCL tumor growth, progression or resistance to treatment. The aim has been to identify novel targets with the potential to eradicate malignant cel

In order to study the limitations and possibilities of age estimation based on tooth wear of skeletal remains from wild boar, 315 mandibles from five different populations of wild boar from Poland, Germany and Sweden were analysed. Asymmetric tooth wear between the right and left mandibles was found to be rare and no systematic difference in tooth wear between males and females (less than 36 month

Condylomas are caused by human papillomavirus (HPV), but may in rare cases be "negative for HPV" by PCR. Metagenomic sequencing can be used for an unbiased assessment of the presence of virus. Ten swab sample pools, each containing four cases of "HPV-negative" condylomas, were subjected to metagenomic sequencing. One pool contained Molluscum contagiosum. Five pools contained HPV, of which three po

The abundant serine proteinase inhibitor heparin cofactor II (HCII) has been proposed to inhibit extravascular thrombin. However, the exact physiological role of this plasma protein remains enigmatic. In this study, we demonstrate a previously unknown role for HCII in host defense. Proteolytic cleavage of the molecule induced a conformational change, thereby inducing endotoxin-binding and antimicr

Celiac disease is an autoimmune disease characterized by inflammation localized to the small bowel, but less is known about systemic signs of inflammation. The aim was to measure cytokines of the T helper 1 (Th1) and T helper 2 (Th2) cell patterns in children with screening detected celiac disease before and after treatment with a gluten free diet.

Functional analysis of quantitative expression data is becoming common practice within the proteomics and transcriptomics fields; however, a gold standard for this type of analysis has yet not emerged. To grasp the systemic changes in biological systems, efficient and robust methods are needed for data analysis following expression regulation experiments. We discuss several conceptual and practica

Pattern recognition is an integral part of the innate immune system. The human contact system has been shown to interact with the surface of many bacterial and fungal pathogens, and once activated leads to the generation of antimicrobial peptides and the proinflammatory mediator bradykinin. Here we show that apart from these surfaces also neutrophil extracellular traps (NETs) provide a surface tha

A study of some of the most (in)famous text forgeries in history: the Ems telegramme, the Constantinian Donation, fibula Praenestina, and anonymous letters in the 1950-ies, and others.

Fungi, such as Candida spp., are commonly found on the skin and at mucosal surfaces. Yet, they rarely cause invasive infections in immunocompetent individuals, an observation reflecting the ability of our innate immune system to control potentially invasive microbes found at biological boundaries. Antimicrobial proteins and peptides are becoming increasingly recognized as important effectors of in

Abstract The purpose of this study was to explore how persons with severe mental illness (SMI) experience oral health problems (especially dry mouth), and weigh the support they received in this regard from professionals and staff at community-based congregate housing through a controlled intervention programme. Oral health problems and dry mouth are found in association with apathy and indifferen

Anaerobic bacteria dominate the human normal microbiota but strikingly little is known about these commensals. Finegoldia magna is a Gram-positive anaerobe found in the skin and at other non-sterile body surfaces, but it is also an opportunistic pathogen. This study describes a novel protein designated FAF (F. magnaAdhesion Factor) and expressed by more than ninety percent of F. magna isolates. Th

Vitronectin (Vn) is a multifunctional glycoprotein profusely present in serum and bound to epithelial cell surfaces. It plays an important role in cell migration, tissue repair and regulation of membrane attack complex (MAC) formation. In the last decade the role of Vn has been extensively investigated in eukaryotic signalling and cell migration leading to the possibility of developing novel antic