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We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterise their association with intermediate phenotypes, and to investigate their role in T2D risk among normal-weight, overweight and obese individuals.We investigated the association of genetic scores with euglycaemic-hyperinsulinaemic clamp- and OGTT-based measures of insulin resistance and secreti
Epidemiological studies have shown low-grade inflammation measured by high-sensitivity C-reactive protein (hs-CRP) to be associated with fracture risk in women. However, it is still unclear whether hs-CRP is also associated with fracture risk in men. We therefore measured serum levels of hs-CRP in 2910 men, mean age 75 years, included in the prospective population-based MrOS Sweden cohort. Study p
Background. In formal experiments on software engineering, the number of factors that may impact an outcome is very high. Some factors are controlled and change by design, while others are are either unforeseen or due to chance. Aims. This paper aims to explore how context factors change in a series of for- mal experiments and to identify implications for experimentation and replication practices
Caloric restriction has been found to be protective against the development of type 2 diabetes mellitus (T2D) in experimental animal studies. However, studies examining this association in humans are limited. In the present study, we examined whether individuals with anorexia nervosa, one marker of severe caloric restriction in humans, have a low incidence of T2D by using several Swedish registrie
Calculation of relative humidity and temperature in an early stage of the design process is important to avoid moisture damages in wooden walls. Previous studies show that a sufficient air flow in the air gap behind the façade panel is important to ensure a moisture safe construction. This study investigates if blind WUFI 5.0 calculations with a varied air flow in the air gap behind the façade giv
Popular Abstract in Swedish Länge trodde man att mikroorganismer spreds obehindrat på grund av deras ringa storlek och höga celltäthet. Eftersom de är väldigt små kan de lätt transporteras i vattendroppar med hjälp av vinden eller genom att fästa vid andra organismer så som fåglar och insekter. Endast miljöförhållanden som gynnade särskilda mikrober troddes påverka arters spridning och organismsamFor a long time microorganisms were assumed to have unlimited dispersal due to their small size and high cell numbers. Most microbial species can be transported by water currents, in water droplets by wind and attached to other organisms. Environmental conditions alone were supposed to affect the distribution of species and the community composition. Therefore, microorganisms were assumed to consi
STUDY DESIGN: Cross-sectional. BACKGROUND: The association between muscle function and lack of knee confidence in people with anterior cruciate ligament (ACL) injury has not been well investigated. Such knowledge would help in the design of training programs for this population. OBJECTIVE: To investigate associations between self-reported knee confidence and muscle function in patients with ACL in
The aim of this work was to study the effect of time between adrenaline injection and slaughter on the rate and extent of post-mortem metabolism in pig muscle. Five pigs were subcutaneously injected with adrenaline (0·3 mg/kg) or with a saline solution 4 h, 1 h or 15 min prior to slaughter. pH1, pHu and FOPu were measured in Longissimus dorsi (LD) and Biceps femoris (BF) muscles. m.LD samples were
Checkpoint blockade of CTLA-4 results in long-lasting survival benefits in metastatic cancer patients. However, patients treated with CTLA-4 blockade have suffered from immune-related adverse events, most likely due to the breadth of the induced T-cell activation. Here, we investigated the efficacy of a local low-dose anti-CTLA-4 administration for treatment of subcutaneous or orthotopic murine bl
International bi-lateral agreements to support the conservation of rainforests to reduce greenhouse gas emissions are growing in prevalence. In 2009, the governments of Guyana and Norway established Guyana’s Low Carbon Development Strategy (LCDS). We examine the extent to which the participation and inclusion of Guyana’s indigenous population within the LCDS is being achieved. We conducted a sing
In Nampula province, Mozambique, there is a high number of water wells considered as having failed for having too low a pumping yield. Two Electrical Resistivity Tomography (ERT) measurement campaigns were conducted in the area for evaluating the reasons of failures. However, in some cases it was difficult to verify and interpret the ERT results by only using the inadequate lithological descriptio
PURPOSE: Rectal cancer is the most common reason for a person to undergo ostomy surgery. The aim of this study was to assess concerns and health-related quality of life (HRQOL) before surgery and during the first 6 months following ostomy surgery in the presence of rectal cancer.SUBJECTS AND SETTINGS: The sample comprised 57 patients at a university hospital in Gothenburg, Sweden. Their median age
The negative effects of climate change are calling for action to mitigate and adapt to future challenges. National crisis management authorities need to prepare to handle crisis caused by direct or indirect effects. In this study, we investigate how crisis management authorities within the European Union prepare for the effects of climate change by conducting a small questionnaire study. The quest
In this study, we analysed the agonist-promoted trafficking of human B2 (B2R) and B1(B1R) bradykinin (BK) receptors using wild-type and green fluorescent protein (GFP)-tagged receptors in HEK293 cells. B2R was sequestered to a major extent upon exposure to BK, as determined by the loss of cell-surface B2R using radioligand binding and by imaging of B2R-GFP using laser-scanning confocal fluorescenc
The mallard Anas platyrhynchos is a reservoir species for influenza A virus in the northern hemisphere, with particularly high prevalence rates prior to as well as during its prolonged autumn migration. It has been proposed that the virus is brought from the breeding grounds and transmitted to conspecifics during subsequent staging during migration, and so a better understanding of the natal origi
Background: Coronary artery remodelling and vasospasm is a complication of acute myocardial ischemia and reperfusion. The underlying mechanisms are complex, but the vasoconstrictor peptide endothelin-1 is suggested to have an important role. This study aimed to determine whether the expression of endothelin-1 and its receptors are regulated in the myocardium and in coronary arteries after experime
