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Psoriasis is a complex genetic disease of unresolved pathogenesis with both heritable and environmental factors contributing to onset and severity. In addition to a disfiguring skin inflammation, approximately 10-40% of psoriasis patients suffer from destructive joint involvement. Previously, we reported that the CD18 hypomorphic PL/J mouse carrying a mutation resulting in reduced expression of th
One of the major quantitative trait loci (QTLs) associated with arthritis in crosses between B10.RIII and RIIIS/J mice is the Cia5 on chromosome 3. Early in the congenic mapping process it was clear that the locus was complex, consisting of several subloci with small effects. Therefore, we developed two novel strategies to dissect a QTL: the partial advanced intercross (PAI) strategy, with which w
Background: The spectrum of human non-pylori Helicobacter infections is expanding, with species such as H. heilmannii and H. felis occasionally being associated with gastritis. However, the existence of non-pylori Helicobacter colonization in asymptomatic subjects has not been evaluated. The aim of this study was to investigate whether Helicobacter species other than pylori are present in the uppe
To describe the Avodart after Radical Therapy for prostate cancer Study (ARTS), investigating the use of dutasteride (a dual 5 alpha-reductase inhibitor that suppresses intraprostatic dihydrotestosterone, reduces tumour volume and improves other markers of tumour regression in prostate cancer) to prevent or delay disease progression in patients with biochemical recurrence after therapy with curati
Abstract The overall aim of this thesis was to increase knowledge about underlying causes and perioperative risk factors of Acute Confusional State (ACS) in elderly patients with hip fracture and to investigate the effect of a multi-factorial intervention program in order to decrease the number of patients who develop ACS. The aim in paper I was to describe elderly patients with hip fracture on th
Abstract Objective: To assess the cost-effectiveness of insulin detemir compared with Neutral Protamine Hagedorn (NPH) insulin when initiating insulin treatment in people with type 2 diabetes mellitus (T2DM) in Denmark, Finland, Norway, and Sweden. Methods: Efficacy and safety data were derived from a 20-week multi-centre randomized controlled head-to-head clinical trial comparing insulin detemir
The elderly population is increasing and with advanced age comes a higher risk for contracting diseases and excessive medicine use. Polypharmacy can lead to drug-related problems and an increased need of health care. More needs to be done to help overcome these problems. In order for new models to be successful and possible to implement in health care they have to be accepted by caregivers. The ai
Popular Abstract in Swedish Patienter med diabetes kan inte kontrollera blodsockernivåerna på grund av att de saknar insulinproducerande celler eller har icke fungerande insulinproducerande celler. Det finns olika typer av diabetes där typ 1 diabetes och typ 2 diabetes är de vanligaste formerna. Den mest framgångsrika behandling mot typ 1 diabetes är transplantation av insulinproducerande celler, Diabetes - the imbalance in glucose homeostasis is partially caused by loss or dysfunction of pancreatic insulin producing β cells or development of insulin resistance. In Type 1 diabetes β cells are destroyed in the process of an autoimmune attack, whereas in Type 2 diabetes, islets produce insufficient amounts of insulin or the insulin cannot be used adequately. So far, the most promising therap
Popular Abstract in Swedish Spel om pengar har blivit ett utbrett fenomen i Sverige under 1990-talet, med spelbutiker, spelhörnor i varuhusen, spelmaskiner och spel med kort och på roulette på pubar, pizzerior och restauranger, samt spel på Bingo-Lotto hemma i vardagsrummet. Förutom den ökade tillgången till legala spelformer blir det allt vanligare med spel i miljöer och sammanhang där det inte fGambling has become widely accepted in Sweden during the 1990s, with betting shops, gambling machines and casino-like gambling in pubs and restaurants, as well as Bingo-Lotto in our living rooms. Beyond the expansion in availability of legal gambling opportunities, the most notable change is the shift from gambling in specific venues to gambling in a much wider range of social settings. The conseq
Popular Abstract in Swedish Denna studie fokuserar på distriktssköterskors hälsovägledning i barnhälsovården. Syftet med studien är att öka förståelsen för hur hälsovägledning utformas och genomförs, samt att generera teori, användbar för praktisk barnhälso-vårdsverksamhet. Data samlades in genom videoobservationer med efterföljande intervjuer, fältanteckningar, anteckningar från gruppdiskussionerChild Health Services (CHS) form a strategic arena for Swedish health promotion, from a societal as well as individual perspective. The present study focuses on district nurses´ health counselling in CHS. The aim is to improve understanding of what is important in shaping and accomplishing health promotion, and to generate theory useful in a CHS context. Data were collected at CHS in primary healt
The article investigates translation culture in the Swedish dominion Swedish Pomerania during the eighteenth century, with a particular focus on periodicals.
Popular AbstractI avhandlingen undersöks den ekonomiska omvandlingsprocess som skett i Sverige sedan mitten av 1970-talet. Av speciellt intresse är hur och varför de fördelar som företag och branscher åtnjuter på grund av samlokalisering med andra ekonomiska aktörer (så kallade agglomerationsexternaliteter) varierar över olika faser av ekonomisk omvandling. Avhandlingen baserar sig på de framsteg This thesis investigates the process of economic transformation taking place in Sweden since the mid 1970s. Especially, it is concerned with how and why benefits that firms and industries draw from regional co-location with other actors (agglomeration externalities) vary over stages of economic transformation. Drawing on recent findings within the fields of evolutionary economics and evolutionary
Introduction: A Task Force was commissioned jointly by the European Academy of Allergy and Clinical Immunology (EAACI) and the Respiratory Effectiveness Group (REG) to develop a quality assessment tool for real-life observational research to identify high-quality real-life asthma studies that could be considered within future guideline development. Methods: The resulting REal Life EVidence Assessm
In situ X-ray absorption spectroscopy (XAS) investigations have been performed to provide insights into the reaction mechanism of a palladium(ii) catalyzed undirected C-H acetoxylation reaction in the presence of an oxidant. A Pd(ii) N-heterocyclic carbene complex π-stacked onto reduced graphene oxide (rGO) was used as the catalyst. The Pd speciation during the catalytic process was examined by XA
Large, comprehensive studies of the risk for neurologic disorders among long-term survivors of noncentral nervous system (CNS) childhood cancers are lacking. Thus, the aim of our study was to assess the lifetime risk of Nordic non-CNS childhood cancer survivors for neurologic disorders. We identified 15,967 5-year survivors of non-CNS childhood cancer diagnosed in Denmark, Iceland, Finland and Swe
PURPOSE: Helicobacter pylori is a human gastroduodenal pathogen associated with type-B gastritis and gastric cancer. Low gastric tissue antioxidant levels are believed to increase the risk of developing gastric cancer. We investigated whether dietary antioxidant levels protect against infection and type-B gastritis in H. pylori-infected guinea pigs. METHODS: Dunkin-Hartley guinea pigs infected for
The aim of this study is to examine the development of linguistic proficiency in written production of second-language French. In a longitudinal study of 30 months, we follow the written production of 5 guided learners of French as a second language. In order to apprehend proficiency we use the conventional parameters fluency, complexity and accuracy. The fluency and complexity are apprehended by
A self-report instrument assessing work-related factors among people with psychiatric disabilities would be useful when trying to match possible employment or prevocational opportunities with people’s desires and capacities. The aim of this study was to explore the factor structure, internal consistency, and construct and criterion validity of the Worker Role Self-Assessment (WRS) in this group as
Anaphylaxis/anaphylactoid reactions have recently been reported after few treatments with factor IX concentrates in patients with haemophilia B at the same time as inhibitors to factor IX were demonstrated. In some of these cases nephrotic syndrome has appeared during immune tolerance induction (ITI) with high doses of factor IX concentrates. Gene deletions seem to be associated with a high risk o
