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Introduction. The introduction of publicly available large language models (LLMs) since 2022 has significantly challenged traditional library and information studies (LIS) core concepts. This paper argues that LIS needs to rethink aspects of its conceptual framework to address the challenges posed by the proliferation of AI-generated content and how this content is produced.Analysis. The study emp

Radiative lifetimes have been determined for the 62P12/0 and 62P32/0 levels in Yb II using the method of laser-induced fluorescence from sputtered metal vapour. The results, 8.0(2)ns (62P12/0) and 6.3(3)ns (62P32/0), are compared with lifetimes obtained from ab initio manybody perturbation calculations.

A novel mechanism of sequestering tumor suppressor mRNAs reveals new therapeutic vulnerabilities in leukemic cells.

This is the third of three chapters on diffusion MRI acquisition for tractography. Tractography is performed extensively in the in vivo adult brain, and sequences used for the in vivo adult brain have been covered in detail in Chapter 7. However, tractography is also performed in ex vivo human brain, in both the in vivo and ex vivo animal brain of various nonhuman species, in the human brain durin

In a large social science literature, unequal rural class structures (“landlordism”) are associated with authoritarian political outcomes. This paper revisits the debate, focus- ing on the landlords’ ideological domination of the lower classes and anti-democratic attitudes in estate-dominated areas. We contrast the authoritarian landlordism model with a perspective where inequality fosters leftist

Conducting digital research on the far-right continuum (covering a broad array of actors further to the right from what is generally considered the mainstream right), evokes several serious ethical challenges. This becomes particularly poignant in cases whose research subjects hold illiberal, extreme, and potentially hostile views toward the researcher. In this chapter, we critically reflect on th

Background: MicroRNA-379 (miR-379) has been reported to play a tumour-suppressing role in several cancer types. Our previous work demonstrated that miR-379 overexpression attenuates the metastatic spread of prostate cancer (PCa) both in vitro and in vivo. However, the underlying mechanisms remain poorly understood. Methods: To elucidate the mechanisms by which miR-379 affects metastases, we pe

Policymaking around educational technology (ed-tech) is increasingly influenced by networks of public and private actors ranging from Big Tech corporations and international organisations through to ed-tech evidence brokers and consultants. This paper considers a relatively unexplored facet of contemporary ed-tech policy work – public-facing (ex)teachers advocating for technological change through

Lamniform sharks are amongst the largest-bodied extant fishes and have an evolutionary history spanning ~135 million years (Ma). Fossils correlate their initial development of mega-body size (≥ 6 m) with ecological radiation as marine top-predators during the later part of the mid-Cretaceous (after the late Albian, ~100 Ma). Here, we push back this earliest appearance of gigantic lamniforms by ~15

The article discusses the development and application of the so-called “stigma engagement strategy (SES)” in interviews with stigmatized study populations, drawing on an interview study with Swedish men who have paid for sex. SES is a qualitative methodological approach that utilizes external sources of stigmatizing narratives, such as newspaper articles and columns, as textual probes within inter

This paper aims to enhance our understanding of how strategic communication mobilise democratic values and ideals, which civil society is expected to support. Drawing on discourse theory, the paper conceptualises strategic communication as a process that unites various publics. This paper argues that these publics are largely imagined and constructed through communication. It also asserts that the

Plasma phosphorylated tau (p-tau) biomarkers open unprecedented opportunities for identifying carriers of Alzheimer's disease pathophysiology in early disease stages using minimally invasive techniques. Plasma p-tau biomarkers are believed to reflect tau phosphorylation and secretion. However, it remains unclear to what extent the magnitude of plasma p-tau abnormalities reflects neuronal network d

The Permian - Triassic boundary of the Çürük daǧsection (Taurus, Antalya Nappes, Turkey) was sampled for ostracodes. 38 species belonging to 22 genera were discovered. This ostracode fauna is the first one described throughout the Permian - Triassic boundary outside of South China. Six species are new: Sargentina pamucakensis Crasquin-Soleau n. sp., Bairdia kemerensis Crasquin-Soleau n, sp., Baird

Background: Dihydrotestosterone (DHT), the most potent ligand to the androgen receptor, is synthesised from testosterone (T) by 5α-reductase type 1 and 2. While type 1 is expressed in several non-reproductive tissues in both sexes, men also express high levels of the high-affinity type 2 isoform in reproductive tissues; yet women have a higher circulating DHT to T (DHT/T) ratio than men. We hypoth

BACKGROUND: Nitrones such as 2-sulfo-phenyl-N-tert-butyl nitrone (S-PBN) are known to trap and stabilize free radicals and to reduce inflammation. Recently, S-PBN was shown to reduce infiltration of T lymphocytes and the expression of adhesion molecules on the endothelium in experimental traumatic brain injury. We hypothesized that S-PBN could reduce infiltration of T lymphocytes during cell-media

Understanding of mononuclear phagocyte (MNP) diversity in the human intestine and the alterations this compartment undergoes in inflammation remains incomplete. Here, we used single-cell RNA sequencing, cellular indexing of trancriptomes and epitopes by sequencing, flow cytometry, and imaging to explore MNP heterogeneity in human ileal and colonic laminae propriae (LPs) in health and Crohn's disea