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Background: Familial colorectal cancer type X (FCCTX) is a phenotypically defined subset of hereditary colorectal cancer with unknown and potentially heterogeneous genetic aetiology. FCCTX has been characterized as a colorectal cancer-specific syndrome, which we herein challenge by estimating the risk for extra-colorectal cancer in the Danish FCCTX cohort. Methods: Through the national hereditary
Background: Severe alpha-1-antitrypsin deficiency (AATD) is an established risk factor for chronic obstructive pulmonary disease (COPD) and liver disease, but the effect on the incidence of ischemic heart disease (IHD) is not well known. The aim was to evaluate the risk of incident IHD in patients with severe AATD compared with a random sample of the general population, with known smoking habits.
Use of clay brick masonry in façades is often motivated by its aesthetic values and durability. Yet, mortar joints exposed to climate agents erode over time, expected to cause elevated moisture content and water absorption. Thus, it is often recommended that 40- to 50-year-old facades should be repointed – a measure which is intrusive and costly. Decision is in many cases taken without a clear evi
Background: In 2014 the Swedish government assigned to The Public Health Agency of Sweden to conduct studies to evaluate optimal use of existing antibiotic agents. The aim is to optimize drug use and dosing regimens to improve the clinical efficacy. The present study was selected following a structured prioritizing process by independent experts. Methods: This phase IV study is a randomized, open-
Regression models are extensively used in many epidemiological studies to understand the linkage between specific outcomes of interest and their risk factors. However, regression models in general examine the average effects of the risk factors and ignore subgroups with different risk profiles. As a result, interventions are often geared towards the average member of the population, without consid
BACKGROUND: Injury to the white matter may lead to impaired neuronal signaling and is commonly observed following traumatic brain injury (TBI). Although endogenous repair of TBI-induced white matter pathology is limited, oligodendrocyte progenitor cells (OPCs) may be stimulated to proliferate and regenerate functionally myelinating oligodendrocytes. Even though OPCs are present throughout the adul
To meet the needs of an increasing, heterogeneous, ageing population it is imperative to understand links between home and health. In Latvia, only limited research targeting the health and home situation of very old people is available. Consequently, the aim of this study was to describe how the home environment and aspects of health have changed over nine years between 2002 and 2011 for very old
Several studies have shown socioeconomic differences in leisure-time physical activity. One explanation may be socioeconomic differences in relevant psychosocial conditions. The Malmo Diet and Cancer Study is a prospective cohort study including inhabitants in Malmo, Sweden. The baseline questionnaire used in this cross-sectional study was completed by the 11,837 participants born 1926-1945 in 199
Postpartum depression (PPD) är ett globalt folkhälsoproblem. Mödrar som migrerar till ett annat land har en ökad risk att drabbas av PPD. Före-komsten av PPD bland utlandsfödda mödrar beräknas vara så hög som 20 procent, vilket nästan är dubbelt så hög som bland inhemsk västerländsk befolkning. Asylsökande och flyktingar är särskilt sårbara grupper som löper en ännu högre risk att drabbas, speciel
AbstractOverweight and obesity are more common among adult people with mobility disability (MD). Epidemiological studies are sparse in Sweden when it comes to the prevalence of MD and weight, differences between people with MD compared to those without MD, as well as the association to HRQoL. In addition, general guidelines in obesity prevention and treatment adapted to people with MD are lacking
Introduction: The intrapartum cardiotocography (CTG) classification system by FIGO in 2015 (FIGO2015) was introduced to simplify CTG interpretation, but it is not harmonized with the fetal ECG ST analysis (STAN) algorithm from 2007 (STAN2007), which is based on the FIGO CTG system from 1987. The study aimed to determine time courses and sensitivity between the systems in classifying CTG + ST event
INTRODUCTION: We have limited knowledge about the underlying disease mechanisms and causes of pain in hand osteoarthritis (OA). Consequently, no disease-modifying drug exists, and more knowledge about the pathogenesis of hand OA is needed, as well as a validation of different outcome measures. Our first aim of this study is to explore the validity of various imaging modalities for the assessment o
Precipitation is often the most important input data in hydrological models when simulating streamflow. The Soil and Water Assessment Tool (SWAT), a widely used hydrological model, only makes use of data from one precipitation gauge station that is nearest to the centroid of each subbasin, which is eventually corrected using the elevation band method. This leads in general to inaccurate representa
What can we learn by transmitting electrical currents through electrodes in the ground? Geophysical methods can help us to locate the bedrock, valuable mineral ores, remains of ancient buildings and many other secrets hiding below the surface. However, it is not only the universal interest for the unknown that drives the geophysical research forward. Knowledge of, for example, fractured bedrock, c
It is a common joke that Playboy magazine has been “read for the articles.” However, there has been relatively little academic interest in what the articles in Playboy have actually been about. As this essay shows, the volumes of Playboy magazine offer a remarkable archive of critical reviews of US foreign politics. The chapter approaches Playboy as one of the spaces for expanding the political un
Global dementia rates will more than triple by 2050, thus challengingsociety. Due to ageing in place policies, informal caregiving is increasing asmore people with dementia continue living at home despite significant careneeds. While most caregivers are willing to act as such, they are notalways adequately supported, thus reporting a high burden, worse mentaland physical health. Innovative Assisti
AIMS: To evaluate the effect of adding insulin to sulphonylurea (SU) and the effect of SU withdrawal on glycaemic control in Type 2 diabetic patients who failed on treatment with SU alone.METHOD: One hundred and seventy-five patients were included in a placebo-controlled multicentre study. During phase I (4 months), premixed insulin was added to glibenclamide therapy; during phase II (1-4 months,
Understreckare utgående från Benny Morris och Dror Ze'evis bok "The Thirty-Year Genocide"
