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The need to design high performance of a cooled gas turbine is considered with emphasis made on coupled aerodynamic and heat transfer optimization of the vane, blade, and single stage cooled gas turbine by using a multiobjective optimization method. The aerodynamic profile is designed to have three sections and the cooling structure to consist of a serpentine passage, with a tail transverse channe

Twentieth-century massification of higher education and academic research led to mission diversification and structural diversification of national higher education systems (HESs), but also a tendency of non-university colleges to seek to develop into full-scale universities by the emulation of practices of established academic organizations, a tendency that has been called academic drift. The dri

The Gaia mission has been designed to perform absolute astrometric measurements with unprecedented accuracy; the end-of-mission parallax standard error is required to be of the order of 10 mu as for the brightest stars (V= 10) and 30 mu as for a G2V-type star of magnitude 15. These requirements set a stringent constraint on the accuracy of the estimation of the location of the stellar image on the

PI3-kinase has a crucial role in transformation mediated by the oncogenic c-Kit mutant D816V. In this study, we demonstrate that the c-Kit/D816V-mediated cell survival is dependent on an intact direct binding of PI3-kinase to c-Kit. However, mutation of this binding site had little effect on the PI3-kinase activity in the cells, suggesting that c-Kit/D816V-mediated cell survival is dependent on PI

Aims/hypothesis To develop a prediction model that can predict HbA1c levels after six years in the non-diabetic general population, including previously used readily available predictors. Methods Data from 5,762 initially non-diabetic subjects from three population-based cohorts (Hoorn Study, Inter99, KORA S4/F4) were combined to predict HbA1c levels at six year follow-up. Using backward selection

Fibrinogen can support host antimicrobial containment/clearance mechanisms, yet selected pathogens appear to benefit from host procoagulants to drive bacterial virulence. Here, we explored the hypothesis that host fibrin(ogen), on balance, supports Staphylococcus aureus infection in the context of septicemia. Survival studies following intravenous infection in control and fibrinogen-deficient mice

The significance to human postural control of pressor information from the feet was investigated during vestibular disturbance in seven normal subjects who were exposed to bipolar biaural galvanic stimulation of the vestibular nerves before and after their feet were anaesthetized with hypothermia. The increase in body sway in the lateral plane induced by the galvanic stimulus was enhanced when the

Purpose: Cross-sectional studies have shown an association between different coping styles and suicidal behavior. It is unknown whether there is any prospective association between coping behaviors and suicide in the general population. Methods: The study population consisted of participants of the Japanese Public Health Center-based Prospective Study. In the 10-year follow-up questionnaire, subje

OBJECTIVES: Assessing the burden of maternal mortality is important for tracking progress and identifying public health gaps. This paper provides an overview of the burden of maternal mortality in the Eastern Mediterranean Region (EMR) by underlying cause and age from 1990 to 2015.METHODS: We used the results of the Global Burden of Disease 2015 study to explore maternal mortality in the EMR count

OBJECTIVES: To report the burden of cardiovascular diseases (CVD) in the Eastern Mediterranean Region (EMR) during 1990-2015.METHODS: We used the 2015 Global Burden of Disease study for estimates of mortality and disability-adjusted life years (DALYs) of different CVD in 22 countries of EMR.RESULTS: A total of 1.4 million CVD deaths (95% UI: 1.3-1.5) occurred in 2015 in the EMR, with the highest n

A multi-stage high pressure reducing valve (MSHPRV) is proposed. It can achieve a multi-stage pressure reducing way. Valve failure mainly occurs under high pressure and high temperature conditions, thus it is necessary to investigate the strength of MSHPRV under those complex conditions. In this paper, the mathematical model of MSHPRV is established and Computational Fluid Dynamics (CFD) method is

Background and purpose - Assessment of potential disparities in access to care is a vital part of achieving equity in health and healthcare. We have therefore studied the effect of socioeconomic status (SES) on the rates of knee and hip replacement due to osteoarthritis. Methods - This was a cohort study in Skåne, Sweden. We included all residents aged ≥ 35 years with consultations between 2004 an

Objective - To assess the effects of intraarticular injections of hyaluronan on symptoms of knee osteoarthritis (OA). Methods - Two hundred and forty patients with symptomatic, radiological knee OA were randomly assigned to treatment with weekly injections for five weeks with either 25 mg of high molecular weight hyaluronan or vehicle. Results were evaluated at weeks 1, 2, 3, 4, 5, 13, and 20 by v

Abstract: Administrative regions do not necessarily correspond to areas that are homogenous in terms of innovation intensity. Although this has been recognized in the literature, quantitative evidence that explicitly considers this problem is rare. Using spatial exploratory analysis on detailed regional data derived from a census of R&D performers in the Czech Republic, we identify local spati

The effect of Ca++, Mg++, K+ and SO=4, and of serum, on the activity of testis hyaluronidase in a carbonic acid-bicarbonate buffer with pH 7.4 was investigated with the turbidimetric method. The ions were added in amounts corresponding to the serum concentration of the ion in question.The turbidity of hyaluronic acid was not modified by the investigated ions nor by serum up to 0.10 ml.The hyaluron

Background: In Europe, residential care homes (RCHs) are replacing hospitals as the place where death occurs, and they play an important role in end-of-life (EOL) care. Objective: The aim was to describe the quality of care during the last 3 months and last 3 days of life of those who died in RCHs as reported by family members. We also investigated whether there were differences in the EOL care of