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Objectives: Cystic fibrosis hepato-biliary involvement (CFHBI) is a common comorbidity in patients with CF and is associated with increased morbidity and mortality. The effect of the new and highly potent CF transmembrane conductance regulator modulator therapy, elexacaftor-tezacaftor-ivacaftor (ETI), on CFHBI, is still unclear. This study aimed to investigate the impact of ETI on liver stiffness

Icy dust particles emerge in star-forming clouds and are subsequently incorporated in protoplanetary disks, where they coagulate into larger pebbles up to millimeter in size. In the disk midplane, ices are shielded from UV radiation, but moderate levels of disk turbulence can lift small particles to the disk surface, where they can be altered, or destroyed. Nevertheless, studies of comets and mete

Blockchain technology is emerging as one of the most transformative forces to have ever reshaped supply chain management, with unique transparency, security, and efficiency. This paper reviews the literature on blockchain technology and applications in core industries such as transportation, manufacturing, food and beverages, and healthcare. At its core, blockchain deploys distributed ledger techn

The paper reports on preliminary findings from a case study of an autobiography-based course element included in the social work professional education program of a Swedish university. In the studied course element, the aim was for autobiographies to provide a platform and catalyst for student reflections on client perspectives as well as for reflexivity in relation to students’ own frames of refe

Purpose There is a need for diagnostic and prognostic biosignatures to improve long-term outcomes in inflammatory bowel disease (IBD). Here, we describe the establishment of the Swedish Inception Cohort in IBD (SIC-IBD) and demonstrate its potential for the identification of such signatures. Participants Patients aged ≥18 years with gastrointestinal symptoms who were referred to the gastroenterolo

Foreign aid for media development has often been associated with the promotion of specific models or ideals for journalism. Efforts by national aid agencies, NGOs, UNESCO, and media organisations have aimed to support journalists worldwide. However, due to limitations in financial sustainability, inadequate media structures, and competing journalistic ideologies in recipient countries, the impact

Identifying specific inhibitors of the MYC oncogene has been challenging, due to off target effects associated with MYC inhibition. This study investigated how the recombinant Escherichia coli Lon protease (rLon), which targets MYC in human cells, inhibits MYC over-activation in models of infection and cancer. In silico predictions identified specific peptide domains of bacterial Lon that target M

We explore whether SAM2, a vision foundation model, can be used for accurate localization of eye image features that are used in lab-based eye tracking: corneal reflections (CRs), the pupil, and the iris. We prompted SAM2 via a typical hand annotation process that consisted of clicking on the pupil, CR, iris and sclera for only one image per participant. SAM2 was found to support better spatial pr

Typical analyses of otolith microchemistry use calcium, a major constituent, as an internal standard, setting its value as a constant and ignoring any potential variations. In fact, patterns do occur in otolith Ca deposition, as can be observed either by repeating the analysis, by creating two-dimensional maps of Ca, or both. Here we present evidence of Ca variations in fish otoliths from analyses

In this snapshot of moonlight farming in Scania, the southernmost province of Sweden, we reflect on moonlighting as a preservation strategy – a particular form of rural life different from the processes of agricultural upscaling and the rhythms and values of large-scale farming. Our immersion in the lives of three moonlight farmers tells a story of resistance, preservation and sense-scapes – a sta

The Gulf Cooperation Council (GCC) countries have experienced significant migration trends in recent decades, with a heavy reliance on foreign labour, particularly from Southern Asia. As of 2024, the GCC hosts 25 million migrants, with Southern Asians constituting a significant proportion. This demographic reality has shaped the region's socio-economic structure, with expatriates dominating the pr

Comprehensive screening of the general population is the only approach capable of identifying the majority of cases with celiac disease. In 2023, the Italian Parliament enacted a law to implement nationwide screening for celiac disease and type 1 diabetes. However, critical decisions regarding the target population, optimal timing, and screening methods remain unresolved. Previous observational st

Sweden's feminist foreign policy (FUP), which was pursued between 2014 and 2022, involved a more strategic anchoring and communication of the country's state feminist tradition and commitment to justice in world politics. The emphasis on gender equality as the basis for foreign policy was largely based on the UN's agenda for women, peace, and security (WPS). Digital diplomacy and social media, whi

The rotational behavior of T=0 and T=1 bands in the odd-odd N=Z nucleus 62Ga is studied theoretically using the spherical shell model (laboratory frame) and the cranked Nilsson-Strutinsky model (intrinsic frame). Both models give a good description of available experimental data. The role of isoscalar and isovector pairing in the T=0 and T=1 bands as functions of angular momentum is studied in the