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INTRODUCTION: Type 1 diabetes (T1D) is caused by the destruction of pancreatic islet beta cells resulting in total loss of insulin production. Recent studies have suggested that the destruction may be interrelated to plasma lipids.OBJECTIVES: Specific lipids have previously been shown to be decreased in children who develop T1D before four years of age. Disturbances of plasma lipids prior to clini
Several lines of evidence suggest that a calcitonin-gene related peptide (CGRP) receptor antagonist may serve as a novel abortive migraine treatment. Here we present data on a human cell line and isolated human vessels for such an antagonist, BIBN4096BS. On SK-N-MC membranes, radiolabelled CGRP was displaced by both CGRP-(8-37) and BIBN4096BS, yielding pK(i) values of 8.5 and 11.4, respectively. F
Prediction of wound healing and major amputation in patients with diabetic foot ulceration is clinically important to stratify risk and target interventions for limb salvage. No consensus exists as to which measure of peripheral artery disease (PAD) can best predict outcomes. To evaluate the prognostic utility of index PAD measures for the prediction of healing and/ or major amputation among patie
Can gonadotrophin receptor variants separately or in combination, be used for the prediction of pregnancy chances in in vitro fertilization (IVF) trials?
The industrial symbiosis (IS) landscape is evolving rapidly. While previous studies have argued for the importance of municipalities participating in the governing of IS, research on the implications of different forms of municipal organization is still lacking. This paper aims to investigate how municipal administration and municipally-owned corporations, as two forms of organization, impact the
The presence of Fe-bound cyanide ligands in the active site of the proton-reducing enzymes [FeFe]-hydrogenases has led to the hypothesis that such Bronsted-Lowry bases could be protonated during the catalytic cycle, thus implying that hydrogen isocyanide (HNC) might have a relevant role in such crucial microbial metabolic paths. We present a hybrid quantum mechanical/molecular mechanical (QM/MM) s
Abstract The integration of Muslim immigrants into the European societal sphere has have recently received the utmost concern of Europeans. This is because Muslim status has changed from ?immigrant? to ?threat? or ?challenge? to peace and prosperity of Europe in the aftermath of 9/11 attacks. Muslim exclusion from social life is now a problem necessitating an urgent solution. At this point, this
Many nation states in Southeast Asia have ratified human rights conventions without abiding by their stipulations. Among factors such as poverty and political disinclination something which has widely been called 'Asian values' is seen by some as a reason for why certain human rights laid out in UN conventions are not adhered to. The crux of the conflict is the claim that particular Asian
Vietnam's entry to market economy as a result of its "doi moi" programme of reform, shifted the responsibility of education financing to households. Although primary education in Vietnam should be free of charge, direct and indirect costs of education cause a great burden on household economy. This study elaborates on the extent to which access to education depends on the income of t
Throughout the world, harmful traditions to women are carried out within the family, e.g., female genital mutilation, forced marriage and dowry murder. Honour killing practice is considered to be the extreme form thereof for its violent consequences on females' right to life. The practice refers to crimes directed toward women on the ground of gender&semic crimes 'whereby the family ki
Immigrants from the Middle East to Sweden have a twice as high prevalence of type 2 diabetes (T2D) and obesity as native-born Swedes. Both obesity and T2D have been linked to increased incidence of cancer, cardiovascular disease (CVD) and all-cause mortality (ACM); however, data on differences between ethnicities are scarce. In a population-based cohort we aimed to study the impact of Middle Easte
PurposeMyelin water imaging (MWI) using multi-echo T2 relaxation is a quantitative MRI technique that can be used as an in vivo biomarker for myelin in the central nervous system. MWI using a multi-echo spin echo sequence currently takes more than 20 min to acquire eight axial slices (5 mm thickness) in the cervical spinal cord, making spinal cord MWI impractical for implementation in clinical stu
Catch-up phenomena have been studied intensively in many manufacturing industries, but they have not been well explored in creative industries. Moreover, the internal heterogeneity of different segments within a specific industry has also largely been overlooked in the catch-up literature. This paper fills these gaps by analyzing the catch-up of a creative industry—the online game industry in Chin
The quality of student-teacher classroom interactions is important to learning, belonging, and success, particularly for students from groups that have been historically excluded from or marginalized in higher education. The literature commonly asserts that one necessary part of high-quality educational interactions (whether in person or online) is trust, but several scholars note that trust has n
Multiple language learning has been largely neglected in L2 motivation research. Recently, complexity principles have been used to model multilingual motivation. In this work, multilingual self-guides are conceptualised as emergent from interactions between the motivation systems of different languages. Motivational systems and their emergent properties are also influenced by the contexts in which
In 1899, the British colonialist Cecil Rhodes went to Berlin to negotiate about his fantastical ‘Cape-to-Cairo’ telegraph and railway scheme with his former nemesis, the German emperor Wilhelm II. Why did this initiative of Rhodes, who was held responsible for the disastrous Jameson Raid and no longer occupied any official position, receive so much coverage and legitimacy in the international pres
