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Aims/hypothesis Genetic and epidemiological studies suggest an association between gestational diabetes mellitus and type 2 diabetes. Both are polygenic multifactorial disorders characterised by beta cell dysfunction and insulin resistance. Our aim was to investigate whether common genetic variants that have previously been associated with type 2 diabetes or related phenotypes would also confer ri
Between 1992 and 2004, 1,140 children (1 to < 15 years) were diagnosed with B-cell precursor acute lymphoblastic leukemia (ALL) in the Nordic countries. Of these, 288 (25%) were positive for t(12; 21)(p 13;q22) [ETV6/RUNXI]. G-banding analyses were successful in 245 (85%); 43 (15%) were karyotypic failures. The modal chromosome numbers, incidence, types, and numbers of additional abnormalities, ge
The non-obese diabetic (NOD) mouse spontaneously develops diabetes and sialadenitis. The sialadenitis is characterized by histopathological changes in salivary glands and functional deficit similar to Sjögren's syndrome. In humans, Sjögren's syndrome could be associated with other connective tissue disorders, such as rheumatoid arthritis. In the present study the genetic control of sialadenitis in
Aims: To explore the incidence, severity, time course, and risk factors of clinically significant hyponatremia in desmopressin treatment for nocturia. Methods: Data from three multi-center phase 111 trials were pooled. Hyponatremia was categorised as borderline (134-130 mmol/L) or significant (<130 mmol/L). Risk factors were explored with logistic regression and subgroup analysis performed to expl
Popular Abstract in Swedish I denna avhandling beskrivs sambanden mellan funktion i centrala delar av näthinnan, och dess struktur, vid några valda ärftliga och förvärvade sjukdomstillstånd i näthinnan. Denna jämförelse är möjlig genom den relativt nya utvecklingen av multifokalt ERG (mfERG), med vars hjälp centrala näthinnans funktion kan bedömas, samt optisk koherens tomografi (OCT), med vilken In this thesis, retinal function in general, as well as central retinal function and structure are described in selected forms of acquired and hereditary retinal disorders, in order to improve our understanding of underlying pathogenic mechanisms. This comparison has been made possible during the last years, through the relatively recent development of multifocal ERG (mfERG) and optical coherence
BACKGROUND AND AIMS: The optimal position for pH electrode placement in the diagnosis of gastroesophageal reflux disease (GERD) is unknown. The aim of this study was to evaluate the discriminatory power of targeted pH recording immediately above the squamocolumnar junction (SCJ) and to compare the results with those obtained by simultaneous recording at the conventional level for pH monitoring. SU
Background: Despite uniform operating techniques, lack of fusion still occurs after ankle arthrodesis. Differences in the biological healing potential may be a factor but the mechanical performance of the arthrodesis construct because of varying bone quality also may be important. Internal compression techniques are preferred because of higher union rates, shorter fusion times, and fewer complicat
Spatial ecology focuses on the role of space and time in ecological processes and events from a local to a global scale and is particularly relevant in developing environmental policy and (mandated) monitoring goals. In other words, spatial ecology is where geography and ecology intersect, and high-quality geospatial data and analysis tools are required to address emerging issues in spatial ecolog
Objectives: The aim of this study was to evaluate the efficacy of the natural antioxidant astaxanthin in functional dyspepsia in different doses and compared with placebo. Design: The study was a controlled, prospective, randomized, and double blind trial. Participants: Patients with functional dyspepsia, divided into three groups with 44 individuals in each group (placebo, 16 mg, or 40 mg astaxan
Popular Abstract in Swedish Hjärnan är ett av människans viktigaste organ och är det centra som styr våra känslor, minnen och sociala färdigheter. Hjärnan är också det organ som signalerar till musklerna i kroppen att utföra rörelser. När en person drabbas av Parkinsons sjukdom minskar signaleringen till musklerna, vilket medför att det blir svårt att röra sig och stelhet uppstår. Sjukdomen beror Cell-replacement therapy is a promising approach for treating patients with Parkinson ́s disease (PD). For this purpose, there is a need for developing a protocol that can generate high numbers of human transplantable mesencephalic dopaminer- gic (mesDA) neurons. For decades, studies have therefore been made in mouse and other model organisms in order to elucidate key-factors that can be used for
In this study, cancer patients' characteristics associated with death in nursing homes were explored. The study sample included 395 cancer patients who had participated in a trial of palliative care, 260 ( 66%) patients died in hospital, 80 (20%) at home and 55 (14%) in nursing homes. Health-related quality of life was prospectively recorded using the EORTC QLQ-C30 questionnaire. Death in nursing
Syfte: undersöka och jämföra eventuella skillnader i upplevelse av delaktighet och livskvalitet hos två grupper av människor med para- eller tetraplegi. En grupp har medverkat på rekryteringsgruppens läger och den andra gruppen har inte varit på något läger men antagits till nästa. Design: Statisk gruppjämförelse av två grupper där den ena har genomgått ett läger av rekryteringsgruppen. Metod: E
Land cover and land use is well known to be one of the main drivers of erosion and soil loss. However, most findings rely on short-term data analysis and focus on only one or two land covers. In our paper we investigate the long-term trade-off between common agricultural land cover changes (sugarcane, pasture, and soybean) and their runoff and soil loss rates, as well as comparing them to forest (
Accurate monitoring of glaciers’ extents and their dynamics is essential for improving our understanding of the impacts of climate and environmental changes in cold regions. The satellite-based Normalized Difference Snow Index (NDSI) has been widely used for mapping snow cover and glaciers around the globe. However, mapping glaciers in snow-covered areas using existing indices remains a challengin
The SM2RAIN (soil moisture to rain) model has been widely used for rainfall estimation worldwide. However, due to the lack of sufficient ground observation, the SM2RAIN model driven by different passive microwave soil moisture products over the Tibetan Plateau has not been fully validated. In this article, four widely used satellite microwave soil moisture products (including SMAP, ASCAT, SMOS, an
The size, volume, variety, and velocity of geospatial data collected by geo-sensors, people, and organizations are increasing rapidly. Spatial Data Infrastructures (SDIs) are ongoing to facilitate the sharing of stored data in a distributed and homogeneous environment. Extracting high-level information and knowledge from such datasets to support decision making undoubtedly requires a relatively so
Increasing land use pressure is a primary force for degradation of agricultural areas. The drivers for these pressures are initiated by a series of interconnected processes. This study presents a novel methodology to analyze drivers of changing land use pressure and the effects on society and landscape. The focus was on characterizing these drivers and relate them to land use statistics obtained f
Introduction: The B-Natural study is a multicentre, multinational, observational study of haemophilia B (HB) designed to increase understanding of clinical manifestations, treatment and quality of life (QoL). Aim: To characterise and compare QoL in HB across disease severity groups and individuals with inhibitors to identify gaps in treatment. Methods: A total of 224 individuals from 107 families
