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The proline-rich domain (PRD) of the tumor suppressor p53 plays a central role in modulating conformational dynamics and molecular interactions, yet its intrinsic structural behavior remains incompletely understood. Here, we combine extensive all-atom molecular dynamics simulations with biophysical validation to characterize the conformational ensemble of the p53 PRD. The domain behaves as an intr

In recent years the treatment of cancer with radioactive drugs, here termed molecular radiotherapy (MRT), has emerged to take a place alongside other treatment modalities, particularly non-radioactive drugs (NRDs) and external beam radiotherapy (EBRT). A purpose-built tool was developed within the Python programming environment to review the evolution of clinical trials performed in the first quar

The Kagome lattice has emerged as a promising platform for hosting unconventional chiral charge orders at high temperatures. In the context of the correlated Kagome superconductor LaRu3Si2, a room-temperature charge-ordered state with a propagation vector of ((Formula presented.), 0, 0) is previously reported. However, understanding the interplay between this charge order and superconductivity, pa

We present a comprehensive study of the short-ranged nuclear and magnetic order in the two-dimensional spin glass, Mn0.5Fe0.5PS3. Nuclear neutron scattering data reveal a random distribution of Mn2+ and Fe2+ ions within the honeycomb layers, which gives rise to a spin glass state through inducing competition between neighboring exchange interactions, indicated in magnetic susceptibility data by a

To examine the relationship between bodily disconnection and two indicators of late life well-being – depressive symptoms and meaning in life (MIL) – among older adults residing in nursing homes. Psycho-gerontological research has begun to show increased interest in the physical dimension of ageing – the ageing body – and has focused on older adults’ subjective experiences of their bodies. These s

Populärvetenskaplig sammanfattning: Allt fler rapporter har kommit under de senaste åren som visar på att våg- och stormklimatet har förvärrats sedan 1960-talet. Detta har oroat bland andra återförsäkringsbolag som har betalat ut allt mer pengar till stormrelaterade skador de senaste åren. Andra undersökningar har visat att det nuvarande storm- och vågklimatet inte är värre än det var i början av The effects of a global climatic change on the wind climate of northwestern Europe are investigated with the aid of a regional climate model. There have up to date been few studies of how the wind climate will react to a greenhouse gas warming. Those that have been done are mostly global scale studies and centered on changes in storm activity during the winter season. I’m using data from a regiona

Populärvetenskaplig sammanfattning: Den ökande växthuseffekten, med påföljande klimatförändringar, framträder alltmer som ett av vår tids största miljöproblem. På grund av människans industriella och agrikulturella aktiviteter har atmosfärskoncentrationen av de viktiga växthusgaserna koldioxid (CO2), metan (CH4) och lustgas (N2O) ökat drastiskt. Med hjälp av modeller och beräkningar förutspås det Northern peatlands are important in the context of the climate change. Since they comprise huge amounts of soil organic carbon and are found where the most significant greenhouse warming is predicted, they have the potential to exert major feedback effects on the global warming. Studies of the greenhouse gas exchange in northern peatlands have mainly focused on the growing season when the soil is

Objective: To explore how cancer survivors have experienced their contacts with primary care after being diagnosed with cancer, focusing on the integration between cancer specialist and primary care, and participants’ views on what could make primary care services better at catering to the needs of cancer survivors. Design: A qualitative study in which data was collected through semi-structured di

Traditionally well developed in many countries around the world, occupational therapy targeting older people delivers qualified programmes for preventive home visits, community-based rehabilitation, fall prevention, lifestyle redesign, assistive technology provision, etc. Research findings are to an increasing extent being transferred to practice contexts and serve to successively strengthen the q

Characteristic modes are formulated using the scattering dyadic, which maps incident plane waves to scattered far fields generated by an object of arbitrary material composition. Numerical construction of the scattering dyadic using arbitrary full-wave electromagnetic solvers is demonstrated in examples involving a variety of dielectric and magnetic materials. Wrapper functions for computing chara

A recent case of a flawed medical AI system that was backed by public funding provides an opportunity to discuss the impact of government policies and regulation in AI.

This article explores the theme of suffering in the book of Isaiah using the concept of the absurd, developed by Albert Camus. Confronted with a reality of persistent displacement and suffering, and with Yhwh's indifference to it, the authors/editors of the book of Isaiah accentuate a sense of absurdity of Israelite existence after the Babylonian exile. Some of the more peculiar texts about divine

This chapter describes a preliminary study of sustainable social progress in the Kingdom of Tonga conducted following the 2009 report and recommendations of the Commission on the Measurement of Economic Performance and Social Progress (CMEPSP). Tonga appears to be making reasonable social progress according to GDP, the Human Development Index and Millennium Development Goals metrics. However, clos

This special issue examines anti-gender politics in the specific geographical and cultural space of Eastern Europe. It investigates whether the region is just another battlefield for anti-gender politics, or a unique setting for specific developments and strategies, looking at the impact and the legacy of specific historical experiences, sociological and cultural characteristics. The contributions

Planet host stars with well-constrained ages provide a rare window to the time domain of planet formation and evolution. The NASA K2 mission has enabled the discovery of the vast majority of known planets transiting stars in clusters, providing a valuable sample of planets with known ages and radii. We present the discovery of two planets transiting K2-264, an M2 dwarf in the intermediate age (600