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Background: Tau-PET is a diagnostic tool with high sensitivity and specificity for discriminating Alzheimer’s disease (AD) dementia from other neurodegenerative disorders in well-controlled research environments. The role of tau-PET in real-world clinical practice, however, remains to be established. The aim of the TAP-TAU study is therefore to investigate the impact of tau-PET in clinical practic
Burkitt's lymphomas harbour chromosomal translocations bringing c-MYC into the vicinity of one of the immunoglobulin gene loci. Point mutations have been described within c-MYC in several Burkitt's lymphomas and it has been proposed that translocation into the Ig loci might have transformed c-MYC into a substrate for the antibody hypermutation mechanism. Here we test this hypothesis by exploiting
The locus coeruleus (LC) is an important noradrenergic nucleus that has recently attracted a lot of attention because of its emerging role in cognitive and psychiatric disorders. Although previous histological studies have shown that the LC has heterogeneous connections and cellular features, no studies have yet assessed its functional topography in vivo, how this heterogeneity changes over aging,
Mark. Z Danielewski is known for his experiments with the aesthetics of print in works such as House of Leaves and The Familiar. The chapter examines what happens when the experimental book object is digitalized, focusing on the enhanced e-book version of Danielewski’s The Fifty Year Sword. Drawing on theories on remediation (Bolter and Grusin), bookishness (Pressman, Hayles) and digital materiali
In this essay, I offer the first sustained scholarly discussion of the Know Yourself Skeleton Mosaic (KYSM) within its broader cultural milieu and of its contribution to our understanding of self-knowledge in antiquity. In many ways, the mosaic represents an innovative visual "blend" of several cultural tropes and symbols known from the Greco-Roman world. For example, only here is the concept of s
This thesis studies the process and products of migratory self-adaptation: the practice of a migrant author recreating their own work in a new medium, and the baggage it brings with itself. Migratory self-adaptation is developed and analyzed in this research through a comparative and processual analysis of two cases of adaptation: Persepolis, a French autobiographical graphic novel written and dra
In this book, Blaženka Scheuer explores the zoomorphic content of Zibburta (bee/wasp) and Karkušta (weasel)—demeaning names given by R. Naḥman of b. Meg 14b to Deborah and Huldah, two distinguished prophets of the Hebrew Bible. Looking closely at relevant texts, she explores ancient beliefs about bees, wasps, and weasels, recounting a variety of key literary and visual motifs that highlight the di
The aim of this study was to explore the longitudinal association between reported baseline water intake and incidence of coronary artery disease (CAD) and type 2 diabetes in the Malmö Diet and Cancer Cohort (n = 25,369). Using cox proportional hazards models, we separately modelled the effect of plain and total (all water, including from food) water on CAD and type 2 diabetes risk, whilst adjusti
Background: Cognitive assessment for foreign-born individuals is suboptimal. The Multicultural Cognitive Examination (MCE) was developed for use in culturally, linguistically and educationally diverse populations. The MCE includes the Rowland Universal Dementia Assessment Scale (RUDAS) and performs assessment of memory, verbal fluency, and visuospatial function. Objective: To compare the psychomet
Lately, interest has increased in using Virtual Reality (VR) in residential care facilities to increase accessibility to nature experiences. It is widely acknowledged that nature benefits health, and various theories exist regarding its restorative effects. Studies of virtual natural environments often start from predetermined mediating mechanisms and health outcomes. However, virtual nature is fu
The World Meteorological Organization (WMO) Global Atmosphere Watch (GAW) coordinates high-quality atmospheric greenhouse gas observations globally and provides these observations through the WMO World Data Centre for Greenhouse Gases (WDCGG) supported by Japan Meteorological Agency. The WDCGG and the National Oceanic and Atmospheric Administration (NOAA) analyse these measurements using different
Monoamine oxidases (MAOs) A and B are flavoenzymes responsible for the metabolism of biogenic amines such as dopamine, serotonin and noradrenaline. In this work, we present a comprehensive study of the rate-limiting step of dopamine degradation by MAO B, which consists in the hydride transfer from the methylene group of the substrate to the flavin moiety of the FAD prosthetic group. This article b
Monoamine oxidase (MAO), which exists in two isozymic forms, MAO A and MAO B, is an important flavoenzyme responsible for the metabolism of amine neurotransmitters such as dopamine, serotonin, and norepinephrine. Despite extensive research effort, neither the catalytic nor the inhibition mechanisms of MAO have been completely understood. There has also been dispute with regard to the protonation s
In this paper, we discuss the pedagogical concepts of socialisation and uncoverage and the theoretical perspective of metanarratives on history and historical concepts as tools to integrate the students of the online Master’s programme Religious Roots of Europe into the practice of the historical study of religion. We describe how we worked in facilitating the typical learning processes
We study the problem of computing the Voronoi diagram of a set of.n2 points with.O(log n)-bit coordinates in the Euclidean plane in a substantiallysublinear in . n number of rounds in the congested clique model with . n nodes.Recently, Jansson et al. have shown that if the points are uniformly at random distributed in a unit square then their Voronoi diagram within the square can be computed in.O(
Software is at the core of digitalisation and is often claimed to play a central role in innovation and in shaping competition across industries and firms. There are yet few studies of the extent and nature of software development across firms. We employ a unique firm-level survey comprising 3,929 firms across Sweden to analyse the distribution and characteristics of firms that invest in software
Surface-associated plasmin(ogen) may contribute to the invasive properties of various cells. Analysis of plasmin(ogen)-binding surface proteins is therefore of interest. The N-terminal variable regions of M-like (ML) proteins from five different group A streptococcal serotypes (33, 41, 52, 53 and 56) exhibiting the plasminogen-binding phenotype were cloned and expressed in Escherichia coli. The re
