Sökresultat

The proline-rich domain (PRD) of the tumor suppressor p53 plays a central role in modulating conformational dynamics and molecular interactions, yet its intrinsic structural behavior remains incompletely understood. Here, we combine extensive all-atom molecular dynamics simulations with biophysical validation to characterize the conformational ensemble of the p53 PRD. The domain behaves as an intr

In recent years the treatment of cancer with radioactive drugs, here termed molecular radiotherapy (MRT), has emerged to take a place alongside other treatment modalities, particularly non-radioactive drugs (NRDs) and external beam radiotherapy (EBRT). A purpose-built tool was developed within the Python programming environment to review the evolution of clinical trials performed in the first quar

The Kagome lattice has emerged as a promising platform for hosting unconventional chiral charge orders at high temperatures. In the context of the correlated Kagome superconductor LaRu3Si2, a room-temperature charge-ordered state with a propagation vector of ((Formula presented.), 0, 0) is previously reported. However, understanding the interplay between this charge order and superconductivity, pa

We present a comprehensive study of the short-ranged nuclear and magnetic order in the two-dimensional spin glass, Mn0.5Fe0.5PS3. Nuclear neutron scattering data reveal a random distribution of Mn2+ and Fe2+ ions within the honeycomb layers, which gives rise to a spin glass state through inducing competition between neighboring exchange interactions, indicated in magnetic susceptibility data by a

To examine the relationship between bodily disconnection and two indicators of late life well-being – depressive symptoms and meaning in life (MIL) – among older adults residing in nursing homes. Psycho-gerontological research has begun to show increased interest in the physical dimension of ageing – the ageing body – and has focused on older adults’ subjective experiences of their bodies. These s

Populärvetenskaplig sammanfattning: Allt fler rapporter har kommit under de senaste åren som visar på att våg- och stormklimatet har förvärrats sedan 1960-talet. Detta har oroat bland andra återförsäkringsbolag som har betalat ut allt mer pengar till stormrelaterade skador de senaste åren. Andra undersökningar har visat att det nuvarande storm- och vågklimatet inte är värre än det var i början av The effects of a global climatic change on the wind climate of northwestern Europe are investigated with the aid of a regional climate model. There have up to date been few studies of how the wind climate will react to a greenhouse gas warming. Those that have been done are mostly global scale studies and centered on changes in storm activity during the winter season. I’m using data from a regiona

Populärvetenskaplig sammanfattning: Den ökande växthuseffekten, med påföljande klimatförändringar, framträder alltmer som ett av vår tids största miljöproblem. På grund av människans industriella och agrikulturella aktiviteter har atmosfärskoncentrationen av de viktiga växthusgaserna koldioxid (CO2), metan (CH4) och lustgas (N2O) ökat drastiskt. Med hjälp av modeller och beräkningar förutspås det Northern peatlands are important in the context of the climate change. Since they comprise huge amounts of soil organic carbon and are found where the most significant greenhouse warming is predicted, they have the potential to exert major feedback effects on the global warming. Studies of the greenhouse gas exchange in northern peatlands have mainly focused on the growing season when the soil is

This thesis makes an ex post evaluation of the EBA initiative and its influence on agricultural exports into the EU. I employ a gravity model for this purpose, and with dummy variables identifying seven groups of (agricultural) products this is a fairly new method. The data consists of 102 low- and middle income countries, of which 33 are LDC, and 2001 - 2005 is the time period covered. This makes

Because of their important role in civil society, charities are often granted a special status in national tax legislation. Many charities initiate activities abroad and come in the realm of EU law, for example, because of cross border investments, fundraising activities and competition with foreign charities. Tax legislation for charities is, however, not harmonized in the EU and varies widely. E

“Garden phlox ‘Alma Jansson’ comes from a smallholding in Roslagen. It has been on the farm at least since 1939 when Stina Jansson moved in. It was her mother-in-law, Alma Jansson, who took care of the plants in the garden. ‘Everything comes from Grandma. She had such beautiful flowers’, said Stina. We do not know where she received or bought this variety, but it was not newly planted in 1939.” Th

Recent evidence shows that rising wage inequality in industrialized countries can partially be attributed to trade integration. However, it is unclear what the mechanisms behind this relationship are. Previous explanations pointed towards the displacement of mid-wage manufacturing workers as a response to rising imports. But for Germany it has been shown that rising exports likewise create manufac

Measurements achieved with ptychographic imaging are a special case of diffraction measurements. They are generated by illuminating small parts of a sample with, e.g., a focused X-ray beam. By shifting the sample, a set of far-field diffraction patterns of the whole sample is then obtained. From a mathematical point of view those measurements are the squared modulus of the windowed Fourier transfo

Whether optoelectronic devices based on metal-halide perovskite semiconductors will become a commercially viable technology will be determined by their intrinsic and operational stability. Recent results indicate there is some reversibility of perovskite degradation in thin films and devices, although mechanistic insight into the processes driving degradation and recovery are still scarce. We here

Objectives: Pericarditis, takotsubo cardiomyopathy and early repolarization syndrome (ERS) are well-known to mimic ST elevation myocardial infarction (STEMI). We aimed to study whether ECG findings of reciprocal ST depression, PR depression, ST-segment convexity or terminal QRS distortion can discriminate between ST elevation due to ischemia and non-ischemic conditions. Design: Eighty-five patient

Building Information Modelling (BIM) objects represent building products in design, simulation, and procurement processes. This paper explores how BIM objects could be created and exchanged to enable the diffusion of innovative products with enhanced sustainability performance. Two BIM library platforms were examined by taking a new approach that integrates the concepts of sustainable value, diffu

An online, multimedia edition of 'A Description of the Valley of Chamouni, in Savoy' (1819), by Samuel Glover. This edition brings to light a forgotten and important work of travel literature about Chamonix-Mont Blanc, and documents its close connections with the activities of Mary and Percy Shelley during to the so-called 'Frankenstein Summer' of 1816, and with high-profile exhibitions about Cham

Summary: We studied the risk for hip fracture before and after total knee replacement (TKR) in the entire population in Sweden. Women and men had a low risk for hip fracture before TKR but an increased risk the first year after TKR. Purpose: It is known that osteoarthritis is associated with high bone mass. We therefore studied the risk of hip fracture before and after total knee replacement (TKR)