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Parkinson’s disease (PD) and Alzheimer’s disease (AD) are characterized by pathological accumulation and aggregation of different amyloidogenic proteins, α-synuclein (aSyn) in PD, and amyloid-β (Aβ) and Tau in AD. Strikingly, few PD and AD patients’ brains exhibit pure pathology with most cases presenting mixed types of protein deposits in the brain. Bimolecular fluorescence complementation (BiFC)
Background: Several studies have assessed the Quality of Life (QoL) in Deaf and hard-of-hearing (DHH) children and adolescents. The findings from these studies, however, vary from DHH children reporting lower QoL than their typically hearing (TH) peers to similar QoL and even higher QoL. These differences have been attributed to contextual and individual factors such as degree of access to communi
A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of s=13 TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding
Inadequate molecular and clinical stratification of the patients with high-risk diffuse large B-cell lymphoma (DLBCL) is a clinical challenge hampering the establishment of personalized therapeutic options. We studied the translational significance of liquid biopsy in a uniformly treated trial cohort. Pretreatment circulating tumor DNA (ctDNA) revealed hidden clinical and biological heterogeneity,
Habitat preferences and foraging strategies affect population-level space use and are therefore crucial to understanding population change and implementing spatial conservation and management actions. We investigated the breeding season habitat preference and foraging site fidelity of the under-studied and threatened, Baltic Sea population of Caspian Terns (Hydroprogne caspia). Using GPS devices,
This article explores how the acceleration of social time shapes the everyday work of museum and library professionals in Estonia and Sweden. Informed by theories on social acceleration and principles of constructivist grounded theory, 34 semi-structured in-depth interviews were carried out. The ‘symptoms’ of the acceleration of social time create several temporal tensions in organizations, theref
This study appraised and compared the performance of process-based hydrological SWAT (soil and water assessment tool) with a machine learning-based multi-layer perceptron (MLP) models for simulating streamflow in the Upper Indus Basin. The study period ranges from 1998 to 2013, where SWAT and MLP models were calibrated/trained and validated/tested for multiple sites during 1998–2005 and 2006–2013,
Extraction of integral membrane proteins with poly(styrene-co-maleic acid) provides a promising alternative to detergent extraction. A major advantage of extraction using copolymers rather than detergent is the retention of the lipid bilayer around the proteins. Here we report the first functional investigation of the mammalian insulin receptor which was extracted from cell membranes using poly(st
PURPOSE: Children with cerebral palsy (CP) are at risk of cognitive impairments and need to be cognitively assessed to allow for individualized interventions, if applicable. Therefore, a systematic protocol for the follow-up of cognition in children with CP, CP Cog, with assessments offered at five/six and 12/13 years of age, was developed. This report presents and discusses assessment practices i
Background and aim: Primary health care (PHC) supported long-term care facilities (LTCFs) in attending COVID-19 patients. The aim of this study is to describe the role of PHC in LTCFs in Europe during the early phase of the pandemic. Methods: Retrospective descriptive study from 30 European countries using data from September 2020 collected with an ad hoc semi-structured questionnaire. Related var
BACKGROUND: The complement inhibitor CSMD1 acts as a tumor suppressor in various types of solid cancers. Despite its high level of expression in the brain, its function in gliomas, malignant brain tumors originating from glial cells, has not been investigated.METHODS: Three cohorts of glioma patients comprising 1500 patients were analyzed in our study along with their clinical data. H4, U-118 and
OBJECTIVE: The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are inflammatory disorders with ANCA autoantibodies recognising either proteinase 3 (PR3-AAV) or myeloperoxidase (MPO-AAV). PR3-AAV and MPO-AAV have been associated with distinct loci in the human leucocyte antigen (HLA) region. While the association between MPO-AAV and HLA has been well characterised in East A
Health inequalities are a persistent and growing issue in different countries worldwide. Sweden, despite being one of the scandinavian countries with internationally recognized welfare system is no exception. The issue of health disparities and its increase among some groups, including those who are categorised as migrant have been acknowledged. Emergence of the COVID-19 pandemic, however, reveale
Brevmall Postadress Lunds universitet, Box 117, 221 00 Lund Besöksadress Medicon Village, hus 301 Telefon 0730 683 698, 046-2220305 E-post sara.naurin@fs.lu.se, johanna.mellgren@fs.lu.se Webbadress www.fs.lu.se Research Serv ices Lund University’s management rules for standard project applications to the Marcus and Amalia Wallenberg Foundation and the Marianne and Marcus Wallenberg Foundation. Not
https://www.staff.lu.se/sites/staff.lu.se/files/2023-10/Management%20rules%20LU%20MAWMMW2024%20-%20standard.pdf - 2026-06-25
Program 3rd PhD conference on Sustainable Development, 29 September 2023 09:15- 09:45 Welcome and inspirational presentation – acceleration of progress Kristina Jönsson will give a welcome and introduction to the conference, followed by short presentations of the current progress of the 2030 Agenda and the latest updates from the High Level Political Forum. More information regarding the guest spe
SCHEMA 20110322 2018-03-12 Välkommen till kursen MVEN18 Klimatstrategiska metoder VT18 Vi vill hälsa dig välkommen till kursen Klimatstrategiska metoder. Vi hoppas att det ska bli en givande och intressant kurs för dig. I brevet hittar du viktig information om kursen. Med vänliga hälsningar, Lärarlaget genom Niklas Kurstid: 2017-03-20 – 2017-06-03 Kursansvarig: Niklas Vareman, 046-222 09 06, nikla
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/valkomstbrev_mven18_vt18.pdf - 2026-06-25
