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Svensk sammanfattningAvhandlingens syfte har varit att studera utvecklingen av en könskromosom i realtid genom att simulera dess framväxt i en hermafroditisk plattmask i laboratoriet. Jag gjorde detta genom att selektera på dels honlig fitness (fitness via ägg), dels hanlig fitness (fitness via spermier) med hjälp av en genetisk markör, som agerade som en könsbestämmande gen. Detta ska efterlikna Sex chromosome evolution in a hermaphrodite ancestor starts with the establishment of a sex-determining region (SDR). Over time, sex-specific genes, and/or sexually antagonistic alleles will become linked to the SDR. Sexually antagonistic alleles are a type of genetic variation that increases fitness for one sex while being detrimental for the other sex. Recombination arrest around the SDR and gen

Such types of violence seem to emanate from what I would call supremacist resentment, which is driven by the perceived superiority of a given race, ethnicity or nationality over another and which motivates attempts to sabotage “subaltern” success or hinder a supposedly inferior subject from climbing up the social-institutional ladder.

ERP systems became popular with large organizations in the 1990s. In the 21st Century, these products were expanded by addition of supply chain management (SCM) and customer relationship management (CRM), as well as access through the Web, creating the ERP II concept. Efforts to increase the market led vendors to serve not only large organizations, but also focus more on small-to-medium sized ente

Experiments were performed to characterize the so-called leak current of the slowly adapting stretch receptor neurone of the European lobster with respect to its ionic basis, its kinetics and its pharmacology. Estimates of the leak current were obtained by subtraction of a Na-K pump current and of an unspecific impalement current from a non-dynamic ('instantaneous') current, recorded in a voltage

This report summarises the most important lessons learned from the research project From waste management to waste prevention. In the research project, researchers from Lund University and the University of Gothenburg, but also Umeå University and the Royal Institute of Technology, have studied waste prevention.The aim of the project has been to identify and clarify the difficulties in realising t

Objective: To present the baseline data of the international TuberOus SClerosis registry to increase disease Awareness (TOSCA) with emphasis on the characteristics of epilepsies associated with tuberous sclerosis complex (TSC).Methods: Retrospective and prospective patients' data on all aspects of TSC were collected from multiple countries worldwide. Epilepsy variables included seizure type, age a

This report presents basic concepts around resources, resource efficiency and the Circular Economy. The limitations and the opportunities within the Circular Economy are identified and clearly presented. The current policy landscape in the EU as well as in Sweden is thoroughly analysed and a set of policy areas with a significant untapped potential for resource efficiency is identified. The policy

The relationship between environment and migration has gained increased attention since the 1990s when the Intergovernmental Panel on Climate Change projected climate change to become a major driver of human migration. Evaluations of this relationship include both quantitative and qualitative assessments. This review article introduces the concept of scale to environment-migration research as an i

The Cambrian Alum Shale Formation in the Andrarum-3 core from Scania,southern Sweden, consists of black siliciclastic mudstone with minor carbonate intercalations. Four facies comprise three siliciclastic mudstones and one fine-grained carbonate. The facies reflect deposition along a transect from deep ramp to basin on a Cambrian shelf. The three mudstone facies contain abundant clay clasts and la

Objective: This study assessed the applicability and outcomes of the closure of unused cuffs in branched endovascular aneurysm repair (b-EVAR) of thoracoabdominal aortic aneurysm. Methods: We reviewed b-EVAR procedures at a tertiary referral center to identify patients who underwent incomplete branching and needed closure of the unused branch cuffs. An electronic database and intraoperative and fo

In this paper, we consider precoder designs for multiuser multiple-input-single-output (MISO) broadcasting channels. Instead of using a traditional linear zero-forcing (ZF) precoder, we propose a generalized ZF (GZF) precoder in conjunction with successive dirty-paper coding (DPC) for datatransmissions, namely, the GZF-DP precoder, where the suffix ‘DP’ stands for ‘dirty-paper’. The GZF-DP precode

Several risk factors for severe non-proliferative and proliferative retinopathy in type 1 diabetes mellitus have been proposed without explaining the rapid progression of retinopathy in some patients. Since GAD65 autoantibodies (GAD65Abs) are detected against glutamic acid decarboxylase (GAD), which is mainly expressed in islets and nervous tissue in type 1 diabetic patients, the aim of the presen

OBJECTIVES: Airborne exposure to polycyclic aromatic hydrocarbons (PAH) in the potroom of an aluminum reduction plant was studied in relation to genotoxic or mutagenic effects, and the possibility of host genotypes of different metabolizing enzymes modifying associations between PAH exposure and genotoxic or mutagenic response was assessed. SUBJECTS AND METHODS: Ninety-eight male potroom workers a

Most models to predict biochemical recurrence (BCR) of prostate cancer use pretreatment serum prostate-specific antigen (PSA), clinical stage and prostate biopsy Gleason grade. We investigated whether human glandular kallikrein 2 (hK2) and free prostate-specific antigen (fPSA) measured in pretreatment serum enhance prediction. We retrospectively measured total PSA (tPSA), fPSA and hK2 in preoperat

The genetic basis of complete C4 deficiency in a patient with SLE was investigated. Previous studies have demonstrated that this patient has two different major histocompatibility complex (MHC) haplotypes that each contain a major deletion and a non-expressed C4 gene. In the present study, non-expression of the C4 genes was explained by the finding of two distinct C4 gene mutations. A previously d

Multifunktionella landskap producerar mat, fiber och bränsle, samt en mängd andra ekosystemtjänster såsom biologisk mångfald, rekreation, ren luft och rent vatten. I SAPES och associerade forskningsprojekt har vi arbetat med att förstå hur olika jordbruksmetoder och landskapets struktur påverkar biologisk mångfald och ekosystemtjänster som beror av dessa. Vi har testat påverkan på arter och ekosys

Alliances are volatile key components of many corporations' competitive strategies. They offer fast and flexible means of achieving market access, scale economies, and competence development. However, strategic alliances can encounter difficulties that often lead to disappointing performance. The authors suggest that the way partners manage the collective learning process plays a central role in t