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Osteopetrosis due to lack of acid secretion by osteoclasts is characterized by abolished bone resorption, increased osteoclast numbers, but normal or even increased bone formation. In contrast, osteoclast-poor osteopetrosis appears to have less osteoblasts and reduced bone formation, indicating that osteoclasts are important for regulating osteoblast activity. To illuminate the role of the osteocl
P>Overactivity of striatal alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors is implicated in the pathophysiology of l-DOPA-induced dyskinesia (LID) in Parkinson's disease (PD). In this study, we evaluated the behavioural and molecular effects of acute and chronic blockade of Ca2+-permeable AMPA receptors in animal models of PD and LID. The acute effects of the Ca
A correlation between the exocrine pancreatic function and growth has been previously demonstrated in growing pigs but the data are inconsistent. This was investigated by studying the growth performance of pigs with exocrine pancreatic insufficiency (EPI) at different ages and maintained under similar conditions. Twelve 7 week old (10.5 +/- 1.3 kg) weaners, and twelve 16 week old (43 +/- 5 kg) gro
Background: Substance use disorders and complications, such as drug overdose (OD) and suicide attempt (SA), are common among criminal justice clients. Methods: Since 2001, the Swedish Prison and Probation Service has assessed substance-using clients with the Addiction Severity Index (ASI), a semi-structured instrument widely used to examine substance-related problems in different domains of life.
Biophysical models that describe the outcome of white matter diffusion MRI experiments have various degrees of complexity. While the simplest models assume equal-sized and parallel axons, more elaborate ones may include distributions of axon diameters and axonal orientation dispersions. These microstructural features can be inferred from diffusion-weighted signal attenuation curves by solving an i
Popular AbstractDenna rättssociologiska avhandling studerar "law in progress" genom att undersöka de normbildningsprocesser som framkommer i en interaktion mellan aktörer över tid. Avhandlingen har en empirisk utgångspunkt och illustrerar dessa processer utifrån ett empiriskt exempel, ett Europeiskt "Earth Observation" (EO) initiativ: Global Monitoring for Environment and Security (GMES). AvhandliThis PhD-thesis in Sociology of Law studies ”Law in Progress” by investigating norm-generating processes, which emerge through an interaction between actors over time. The thesis has an empirical approach, thus illustrates these processes through an empirical example, a European “Earth Observation” (EO) initiative: Global Monitoring for Environment and Security (GMES). The main research questions
This paper explores home bias and the performance of exchange traded funds (ETFs) and bonds under the context of Environmental, Social and Governance (ESG). It analyzes investment strategies led by non-financial variables such as sustainable and responsible investment and how it affects the expected returns and risk and if the home bias phenomenon is weaker when following the said strategy. The
This thesis aims to provide a deeper understanding of the situation for women in Bosnia and Herzegovina during the pandemic of Covid- 19. Respecting human rights is a conditionality for EU- membership, which Bosnia and Herzegovina applied for in 2015. By drawing on an extensive historical background, conducting an analysis of two documents for directing aid from Sida (the Swedish International Dev
The use of deep eutectic solvents (DESs) has a great potential in the pharmaceutical field due to its many advantages such as biocompatibility, low toxicity and biodegradability. Studies have also shown that proteins can be successfully incorporated into DESs. However, protein stability and structure in these solvents need to be investigated for this technology to be applicable. When adding the pr
Background: The need for a mobile workforce inevitably means that the length of the total work day (working and traveling time) will increase, but the health effects of commuting have been surprisingly little studied apart from perceived stress and the benefits of physically active commuting. Methods: We used data from two cross-sectional population-based public health surveys performed in 2004 an
Model-based process design is increasingly popular when designing pharmaceutical purification processes. The effect of uncertainties in concentration measurements on the estimation of model parameters is analyzed for two cases of non-isocratic adsorption chromatography. A model, calibrated to experiments, is used to generate data by adding a Monte Carlo sampled error in the inlet concentrations. N
OBJECTIVE: Glucose degradation products (GDPs) are important in the outcome of peritoneal dialysis (PD) treatment. 3,4-dideoxyglucosone-3-ene (3,4-DGE) is the most cytotoxic GDP found in conventionally manufactured fluids and may, in addition, be recruited from 3-deoxyglucosone (3-DG). It is not known what happens with those GDPs in patients during PD. The aim of this study was to investigate if t
Animal personality has been widely documented across a range of species. The concept of personality is composed of individual behavioural consistency across time and between situations, and also behavioural trait correlations known as behavioural syndromes. Whilst many studies have now investigated the stability of individual personality traits, few have analysed the stability over time of entire
Psychiatric and metabolic features appear several years before motor disturbances in the neurodegenerative Huntington's disease (HD), caused by an expanded CAG repeat in the huntingtin (HTT) gene. Although the mechanisms leading to these aspects are unknown, dysfunction in the hypothalamus, a brain region controlling emotion and metabolism, has been suggested. A direct link between the expression
The male: female (sex) ratio is of considerable importance in understanding population dynamics of species. A null hypothesis was tested that the male:female (sex) ratio of Carabus species does not differ measurably when entire seasons are considered, but may differ considerably over shorter periods, indicating differences in annual rhythms between the sexes. The sex ratios in nine Carabus species
Background: This is the first longitudinal study with a 22-year follow-up, based on a national and complete sample, to determine whether the prevalence of hip fracture and the age when it occurs are influenced by migration and by being foreign-born. Cultural background and environmental factors such as UV-radiation and lifestyle during childhood and adolescence may influence the risk of a hip frac
In Southeast Asia, transnational activist networks on WTO protests are relatively new networks linking domestic and global activism. This research explores collective identity formation in transnational activist networks, which constitutes the building blocks of social mobilisation. Using the case study of the anti-WTO coalition, networks and social movements particularly in the Philippines and ge
I was searching for the meaning connected to cultural issues and perspectives in a multicultural church, so I questioned 8 church-leaders coming from two churches in Malmö and one in Stockholm. They wrote an answer to an open tailed question. I summarized the text they gave me and let the same leaders and totally fourteen members from the two churches in Malmö react on two of the texts. Finally th
