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Purpose: Identifying biomarkers of radiotherapy (RT) response is important for optimizing the treatment of early breast cancer. In this study, we tested the interaction between endothelial cell (EC) expression of phospho-Tyr397-FAK (pY397-FAK) and adjuvant-RT on clinical outcomes after breast-conserving surgery (BCS) within a randomized study. Preclinical data suggest an enhanced effect of RT on l
Fine-grained windblown deposits, known as loess, in which fossil soils (palaeosols) are preserved, serve as excellent records of past climate. However, paleoclimate reconstruction studies on loess-palaeosol sequences (LPS) in Southeastern Europe have primarily focused on climate changes during the last one or two glacial-interglacial cycles. Surprisingly, little attention has been given to the cli
We use the introduction of covered bonds in Norway in 2007 together with administrative and supervisory data at the bank and loan level to investigate the effect of asset encumbrance, that is, pledging assets as collateral, on the composition of bank balance sheets and bank risk. We show that covered bonds—despite being collateralized with mortgages—lead to a shift in bank lending from mortgages t
When language learning takes place post-migration, the challenge is not only to attain fluency. Learning is tied up with life opportunities and is overshadowed by hopes and fears for the future. In the post-migration phase, hopeful thinking can support the acculturation process. Hope is a goal-related construct that captures variation in adaptability in the pursuit of positive outcomes. It involve
Universities worldwide have increased their competition for the best students and employees. Consequently, business schools are pressured to demonstrate excellence and differentiate themselves through brand building. One essential part of branding is the quality narratives that universities present to the public. We study the presentation of quality in Nordic business schools. Data concerning the
The eighteenth century marks a watershed in European intellectual history. It witnessed the development of many civil rights ideas that were prerequisites for the emergence of modern political systems. One principle that appears to be supported by numerous empirical examples is that evolving political pluralism fostered the right to express one’s views with a certain degree of freedom. This articl
Bovine mastitis is a continuous problem in the dairy industry. The infection has significant impact on health and welfare of animals and causes financial losses for the farmers and the dairy industry. A key bacterium associated with bovine mastitis is Staphylococcus aureus (S. aureus). It produces different exotoxins including more than 24 different staphylococcal enterotoxins and toxic shock synd
Work and working conditions are fundamental social determinants of health. Climate change poses an urgent and growing threat to workers' health, through both direct exposure to environmental hazards and indirect exacerbation of social and health inequalities. Occupational health, which focusses on the promotion of mental and physical health and well-being of workers, is a key but often overlooked
In this work, we have studied how the choice of the continuous phase oils affects droplet-internal acoustic manipulation and mapped the acoustic properties of the selected oils to evaluate their compatibility with droplet acoustofluidic methods. The selection of continuous phase included hydrocarbon, fluorinated, and silicone oils. To map the acoustic properties of the oils, we measured their spee
The intersection of Tolkien’s writing and his environmental agenda have long been studied and the Ents are easily identified as one of the envoys of environmental messages in The Lord of the Rings. The Ents are anthropomorphic Hybrids in their function within the narrative, which can lead to a paradox when considering that ecocritical theories rather disapprove of humanising tools to convey ecolog
This article explores the development process of a sharing platform in the tourism industry, drawing on a longitudinal case study of a sharing-based business in adventure tourism in Sweden. The purpose is to explore how sharing business models emerge through processes of ideological narration—the strategic use of stories to shape and sustain a business. Over a two-year period, empirical data were
Despite the affluence of modern societies, socioeconomic gradients in health and lifespan are widespread across the developed world. A mortality gradient by socioeconomic status (SES) is evident even in the most egalitarian welfare societies, where basic needs like food, safe housing, and health care are universally provided. However, it remains unclear whether such a gradient also existed in hist
Pathogenic mycobacteria require the conserved ESX-1 type VII secretion system to cause disease. In a murine Mycobacterium marinum infection model we previously demonstrated that infiltrating monocytes and neutrophils represent the major bacteria-harbouring cell populations in infected tissue. In the current study we use this model, in combination with scRNA sequencing, to assess the impact of M. m
Despite the prevalence of slavery in world history, our understanding of its persistence remains limited. Most previous studies focus primarily on slavery as a labour contract, indistinguishable from other coercive arrangements such as serfdom. More recent literature on slavery in the United States shows that enslaved people also played an important role as financial instruments. In this article,
Energy-efficient and cost-effective water desalination systems can significantly replenish freshwater reserves without further stressing limited energy resources. Currently, the majority of the desalination systems are operated by non-renewable energy sources such as fossil fuel power plants. The viability of any desalination process depends primarily on the type and amount of energy it utilizes a
