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We conducted pooled and meta-analyses of the association of the calpain-10 gene (CAPN10) polymorphisms SNP-43, Indel-19 and SNP-63 individually and as haplotypes with type 2 diabetes (T2D) in 3237 patients and 2935 controls of European ancestry. In the pooled analyses, the common SNP-43*G allele was associated with modest but statistically significant increased risk of T2D (odds ratio (OR) = 1.11
SummaryElevated HDL-C levels are generally regarded as prognostically favorable in cardiovascular disease. Our study shows that higher HDL cholesterol levels are prospectively associated with 18% increased risk of new-onset fractures in men but not in women. Higher HDL cholesterol may be a novel risk factor for developing fractures in men.PurposeIncreased high-density lipoprotein cholesterol (HDL-
Background Although the role of smoking as a risk factor for emphysema in α1-antitrypsin deficiency (AATD) is well known, never-smokers with severe AATD may also develop lung disease, ranging from mild asymptomatic disease to severe emphysema. Methods We performed a cross-sectional and observational study to analyse the characteristics of the population of never-smoker severe AATD (genotype) indiv
BACKGROUND AND PURPOSE: Adaptive radiotherapy (ART) involves treatment re-planning based on anatomical changes, which may improve target coverage and sparing of organs-at-risk (OARs). This study retrospectively assessed the technical feasibility and potential benefits of daily ART in combination with reduced planning target volume (PTV) margins for head and neck squamous cell carcinoma (HNSCC).MAT
AIMS: To evaluate the long-term clinical and economic outcomes associated with insulin detemir and neutral protamine hagedorn (NPH) insulin in combination with mealtime insulin aspart in patients with type 1 diabetes in Sweden, based on data from a two-year, multi-national, open-label, randomized, controlled trial.METHODS: Insulin detemir was associated with significant improvements in glycaemic c
Drought is a climate risk that affects access to safe water, crop development, ecological stability, and food production. Therefore, developing drought prediction methods can lead to better management of surface and groundwater resources. Similarly, machine learning can be used to find improved relationships between nonlinear variables in complex systems. Initially, the standardized precipitation
Background and purpose — Traditional surgery forarthritis of the distal radioulnar joint (DRUJ), which typicallyinvolves resecting the ulnar head, is being increasingly challengedby newer techniques, such as prosthetic ulnar headreplacement. The aim of our prospective cohort study was toinvestigate the clinical and patient-reported functional results,up to 2 years postoperatively, among patients w
Markvård MASTER I MILJÖVETENSKAP MED NATURVETENSKAPLIG INRIKTNING, 60/120 HP | LUNDS UNIVERSITET UTBILDNINGSUPPLÄGG Masterutbildningen i miljövetenskap är tvåårig där det första året består av valfria inriktningskurser som följs av ett andra år med två obligatoriska miljö- vetenskapliga masterkurser innan vårterminen tar vid med examensarbete. Under utbildningen läser du om miljöproblem samt miljö
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/b_master_markvard_2019_stinas_korr.pdf - 2026-07-01
BACKGROUND: Whereas outdoor temperature is linked to both mortality and hydration status, the hormone vasopressin, measured through the surrogate copeptin, is a marker of cardiometabolic risk and hydration. We recently showed that copeptin has a seasonal pattern with higher plasma concentration in winter. Here, we aimed to investigate the association between outdoor temperature and copeptin.METHOD
Background: Principles of brain plasticity is used in the treatment of patients with functional limitations to improve sensorimotor function. Training is included in the treatment of knee injury to improve both patient-reported function and sensorimotor function. However, impairment in sensorimotor function often persists despite training. Therefore, it was suggested that training programs need to
The aim of this thesis has been to analyze how social workers relate to the child perspective in the processing of social assistance. Previous studies have shown that there is a knowledge gap among social workers how to implement the child's perspective in the management of social assistance. This study has a qualitative research approach and six semi structured interviews have been conducted.
In the light of lean methodology, World Class Manufacturing requires continuous improvement in analyzing the losses to eliminate the wasteful resources and to boost the overall productivity. However, the standardized loss structure should be well-balanced to be general enough to cover the whole manufacturing procedure while being specific enough to point out the real issues happening for further i
I Alternativa övningsmetoder för musiker – del 1 presenteras olika sätt på vilka musikaliska färdigheter kan övas genom mentalisering och andra alternativa övningsmetoder som inte inkluderar användande av musikernas huvudinstrument. Den visar också hur dessa metoder kan kombineras. Här beskrivs även hur och varför dessa arbetssätt fungerar för musikalisk instudering individuellt och i en duo samt Alternative Methods of Practising Music – A study of practising without one’s main instrument for single musicians and small ensembles – Part 1 presents different ways in which musical skills can be practised through imagery and other alternative methods of practising that do not involve the use of the musicians’ main instruments. It also shows how these methods may be combined. Furthermore, it de
The rules of responsibility regarding the working enviroment during the production in the construction industy makes it hard to demand responsibility when accidents occur even when there are flaws in the working enviroment. Flaws in the working enviroment is a big problem on construction sites and there are alot of accidents but at the same time only a few lead to conviction. The way cnstruction s
Background: Transanal endorectal one-stage pull-through (TERPT) procedure in children with Hirschsprung’s disease (HD) has gained worldwide acceptance. However surgical success is often reported separately, while the necessity for true reoperation is difficult to establish. Aim: To evaluate the incidence of reoperations following TERPT procedure. The findings will be important in counseling and pl
The extent to which in-situ global mechanical tensioning (GMT) can be used to modify the residual stress state in friction stir (FS) welds is investigated in this article. Residual stress distributions have been determined by synchrotron X-ray and neutron diffraction for four sets of FS welds in high-strength AA7449-W51 and lithium containing AA2199-T8 aerospace aluminum alloys subjected to a syst
Skatteflykt är ett problem för många av världens suveräna stater. Det finns olika metoder för att bemöta problemet, vanligast är att en stat väljer att instifta en lagstiftning med en generalklausul eller att genom praxis utveckla riktlinjer för när en transaktion skall anses vara skatteflykt. I Sverige och Australien har lagstiftarna valt att genom generalklausuler försöka bekämpa skatteflykt. SyTax avoidance is an issue for many of the sovereign states of the world. Different methods are used in different countries to combat tax avoidance, the most common forms of anti-avoidance measure is either using legislation consisting of a general anti-avoidance rule or using case law to develop general guidelines for when a transaction should be considered tax avoidance. In Sweden and Australia t
Purpose: We investigated the distribution of cannabinoid receptor subtypes 1 and 2 in the detrusor of different species and studied the effects of cannabinoid receptor 1 and 2 agonists on bladder function. Materials and Methods: Cannabinoid receptor 1 and 2 expression was studied with Western blot and immunohistochemistry in rat, monkey and human detrusors. Co-staining was done for markers of sens
