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Purpose: The purpose of this thesis is to find out what pharmaceutical companies are doing in exploitation and exploration to improve R&D productivity. This research will also investigate the implications of management and control theories in combining exploration and exploitation in the context of pharmaceutical R&D. Methodology: Multiple case study interviews. Theoretical perspective
Bakgrunden till detta arbete kom jag i kontakt med då jag under en längre period haft problem med skakningar under konserter. Skakningarna uppstår ofta när jag ska spela någon passage som är extra knepig och krävande eller när jag känner mig kall och ouppvärmd. Jag har tidigare provat metoder för att aktivera kroppen innan man ska spela för att det inte ska uppstå men det problem som kvarstår är aI came into contact with the background of this thesis because I had been struggling with shaking during performances. The shakes would often occur in a difficult passage or when that my hands were cold. I’ve previously tried methods to activate my body before a preformance to try to reduce the amount of shaking but what I’ve encountered is that it often tends to get worse as the concert goes alon
There is a general acceptance that social capital and trust are critical for effective cluster development. While this behavioural additionality forms the central rationale for cluster policies, it remains poorly captured in evaluation. This paper explores progress in evidencing the ‘human element’ in cluster performance.The paper describes a long-term process of collaboration between academics, c
The article begins with a presentation of the role of demonstration and pantomime in the evolution of teaching building on Gärdenfors and Högberg (2017). In comparison to different forms of animal communication, demonstration is voluntary, intentional, honest, and directed to one or a few individuals. Then the differences between demonstration and pantomime is analyzed. An important factor is that
Background: To become a parent of a child who is born small for gestational age can lead to challenges in addition to the newly acquired parenting role. There is currently a lack of knowledge regarding parents' experiences of having a child born small for gestational age. Purpose: The purpose of this study was to describe the experience of becoming a parent of a child small for gestational age Des
Extending the lifetime of products is seen as a key objective for realising the vision of a Circular Economy. One way to increase the lifespan of products is to enable more repair activities. However, consumers encounter a variety of barriers for repairs, prompting public authorities in Europe and the US to adopt or propose policies in support of consumer repairs. Sweden has recently adopted a cir
What is sex work? I have decided to start this short contribution with a question, which I think the reader should answer before continuing. So what is sex work? Is it a legitimate form of work or is it a job whose only characteristics are exploitation, harassment, and coercion? Also, can a person (woman or man) freely decide to be a sex worker or is it impossible to engage in such profession with
BACKGROUND: Early detection of coronary atherosclerosis using coronary computed tomography angiography (CCTA), in addition to coronary artery calcification (CAC) scoring, may help inform prevention strategies. We used CCTA to determine the prevalence, severity, and characteristics of coronary atherosclerosis and its association with CAC scores in a general population.METHODS: We recruited 30 154 r
The environmental impact of products has been increasingly discussed in recent years. In response to questions of the environmental appropriateness of, for example, technologies used to attain a high level of fire safety, a model has been developed to quantify the emissions from fires and include this into a holistic treatment of the environmental impact of a product from the cradle to the grave.
In this study, we revisit the factor analytical (FA) approach for (near unit root) dynamic panel data models, whose asymptotic distribution has been shown to be normal and well centered at zero without the need for valid instruments or correction for bias. It is therefore very appealing. The question is: Does the appeal of FA, which so far has only been documented for fixed effects panels, extends
Serum cystatin C concentration correlates negatively with glomerular filtration rate as well as or better than that of serum creatinine, suggesting a constant formation, and elimination from extracellular fluid mainly by glomerular filtration. It is not known, however, how well the renal plasma clearance of this 13-kDa basic polypeptide matches the glomerular filtration rate. This was investigated
This thesis analyses medals issued between 1560 and 1792 in Sweden and studies the practices and roles related to these objects. It aims to contribute to the understanding of the varying uses and functions of early modern medals by applying a long-term perspective that connects Renaissance, Baroque, and Neoclassical medals. The study asks why are medals commissioned, how the intention is reflected
Lentivirus-based vectors derived from human immunodeficiency viruses type 1 and 2 (HIV-1 and 2) are widely used tools in research and may also be utilized in clinical settings. Like their parental virions, they are known to depend on the cellular machinery for successful gene delivery and integration. While most of the studies on cellular proteomic and transcriptomic changes have focused on the la
Recent clinical trials of mesenchymal stromal cell (MSC) therapy for various inflammatory conditions have highlighted the significant benefit to patients who respond to MSC administration. Thus, there is strong interest in investigating MSC therapy in acute inflammatory lung conditions, such as acute respiratory distress syndrome (ARDS). Unfortunately, not all patients respond, and evidence now su
A growing literature illuminates the limits of claims made on the basis of sensory perception in scientized, rationalized, and bureaucratic contexts. How to understand exceptions to the rule – cases where claims based on sensory experience are taken at face value, even without corroborating evidence? Here, I focus on one such exception, in which citizen complaints about the smell of a small shanty
