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More than 500 colorectal tumors with clonal chromosomal abnormalities have been reported. Although the pattern of aberrations is nonrandom, no specific primary or secondary karyotypic abnormality has been identified. Also, the chronological order in which the aberrations appear during disease progression is not well known. One reason why our understanding of the cytogenetic evolution is unclear is
Introduction The LINC trial evaluated two ALS-CPR algorithms for OHCA patients, consisting of 3 min’ mechanical chest compression (LUCAS) cycles with defibrillation attempt through compressions vs. 2 min’ manual compressions with compression pause for defibrillation. The PARAMEDIC trial, using 2 min’ algorithm found worse outcome for patients with initial VF/VT in the LUCAS group and they received
The energy spectra of electrons produced in multiphoton ionization of rare gases display a large number of peaks corresponding to the absorption of much more than a minimum number of photons required to ionize the atom. A retarding-potential method has been used to analyze the energy of electrons produced in the multiphoton ionization of He, Ne, and Xe at 1064 and 532 nm in a broad range of laser
The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is known to exert various neurotrophic actions in the developing nervous system, but little is known about its distribution in the central nervous system during early development. We have studied the development of GABA-immunoreactive (GABAir) neurons during embryogenesis of a teleost fish, the three-spined stickleback. As early as 51 h po
The mobilisation of psychologists in Sweden working for lesbian, gay, bisexual, trans* and queer (LGBTQ) wellbeing and rights has so far not succeeded in creating continuity despite several attempts to establish some kind of organisation since the mid 1990s. A new attempt was made in 2013 when the Swedish LGBTQ network for psychologists was formed following a formal decision at the congress of the
BACKGROUND: Consistent data on clinical features, treatment modalities and long-term survival in patients with hepatocellular carcinoma (HCC) using nationwide quality registers are lacking. This study aimed to describe treatment patterns and survival outcomes in patients diagnosed with HCC using a national maintained database. METHODS: Characteristics and treatment patterns in patients diagnosed w
Background: Vaccination coverage for infant vaccinations in the Swedish National Immunization Program (NIP) has been high for more than a decade, with approximately 97% of 2-year-old children fully immunized. Vaccination coverage against Human Papilloma Virus (HPV) has been around 80% since introduction for girls in 2012. This indicates high parental confidence in the NIP, but as seen in other Eur
3-Phosphoglycerate dehydrogenase (3-PGDH) deficiency is an inborn error of serine biosynthesis. Patients are affected with congenital microcephaly, psychomotor retardation, and intractable seizures. The effects of oral treatment with amino acids were investigated in 2 siblings. L-Serine up to 500 mg/kg/day was not sufficient for seizure control. Addition of glycine 200 mg/kg/day resulted in comple
Aim: Polypharmacy is becoming a global health problem. The aims of this study were to evaluate the temporal trends in the prevalence of polypharmacy in Sweden and to explore polypharmacy disparities by age, gender, education, and immigration status. Methods: Polypharmacy and excessive polypharmacy were evaluated using data extracted from the Swedish Prescribed Drug Register between 2006 and 2014.
Mitochondria produce ATP via respiratory oxidation of organic acids and transfer of electrons to O2 via the mitochondrial electron transport chain. This process produces reactive oxygen species (ROS) at various rates that can impact respiratory and cellular function, affecting a variety of signaling processes in the cell. Roles in redox signaling, retrograde signaling, plant hormone action, progra
BACKGROUND: The tumor microenvironment plays an important role in the progression of cancer by mediating stromal-epithelial paracrine signaling, which can aberrantly modulate cellular proliferation and tumorigenesis. Exposure to environmental toxicants, such as inorganic arsenic (iAs), has also been implicated in the progression of prostate cancer.OBJECTIVE: The role of iAs exposure in stromal sig
Background:Due to new legislation in 2011 and 2013, the Swedish public healthcare system has undergone change as regards incident reporting and supervision. Focus has turned to learning from adverse events and sharing this learning with actors within the system. The aim of this study was to explore with what underlying safety ontology adverse events in the incident reporting system are investigate
Abstract not available.
Specimens of large fungi (mushrooms) were screened for mutagenic activity by the Salmonella/microsome assay, with strains TA98, TA2637 and TA100. Out of 48 species tested, 37 exhibited a significant but for the most part weak activity. The activity observed in the presence of S9 mix was typically between 0 and 50% of that without, and in no case was the activity increased in the presence of micros
Demineralized bone matrix from young and adult monkeys was implanted intramuscularly for 6 weeks in athymic rats and adult monkeys. Cartilage and bone induction was evaluated by histology and calcium content. In the athymic rat, most implants induced cartilage or bone. In the monkeys, cartilage was formed only on rare occasions and there was no sign of bone formation. We conclude that (a) adult mo
OBJECTIVE: Glucose degradation products (GDPs) are important for the outcome of peritoneal dialysis (PD) treatment. The most cytotoxic GDP found in conventionally manufactured fluids, 3,4-dideoxyglucosone-3-ene (3,4-DGE), may in addition be recruited from 3-deoxyglucosone (3-DG). What happens with the GDPs in the fluid infused into patients during PD is not known. We investigated whether 3,4-DGE a
Molecular dynamics is used to simulate nanometer-sized copper strips. The strips are highly constrained and chosen to mimic thin films between two stiff layers. Further, the strips hold centrally placed straight through crack shaped voids, and are subjected to tensile displacement controlled mode I loading. The tensile stresses and displacements are studied. It is found that if a copper strip is 2
Anomalous small angle scattering measurements have been applied to diluted solutions of anionic polyacrylates decorated by specifically-interacting Pb2+ cations, revealing partial collapse of the polyacrylate into pearl-like subdomains with a size on the order of a few nanometers. From the pure-resonant scattering contribution of the Pb2+ cations, and from subsequent analysis of the resonant-invar
