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The ubiquity of phospho-ligands suggests that phosphate binding emerged at the earliest stage of protein evolution. To evaluate this hypothesis and unravel its details, we identified all phosphate-binding protein lineages in the Evolutionary Classification of Protein Domains database. We found at least 250 independent evolutionary lineages that bind small molecule cofactors and metabolites with ph
Understanding the mechanisms that regulate the dynamics of spatially structured populations (SSP) is a critical challenge for ecologists and conservation managers. Internal population processes such as births and deaths occur at a local level, while external processes such as dispersal take place at an inter-population level. At both levels, density dependence is expected to play a critical role.
BACKGROUND: The diagnostic role of signal-averaged ECG (SAECG) in arrhythmogenic right ventricular cardiomyopathy (ARVC) has lately been questioned. We assessed the value of SAECG-derived late ventricular potentials (LP) in ARVC diagnosis and its association with disease manifestations.METHODS AND RESULTS: Patients with definite ARVC diagnosis or genotype-positive family members who underwent SAEC
BACKGROUND: Mitigation measures implemented in response to the COVID-19 pandemic led to significant changes in maternity care across Europe, including restrictions on companions during labor and birth. This cross-sectional study explores the association between the presence of a companion of choice and a positive perception of the birth experience. Additionally, it explores the association between
In this paper we study the evolution of radiative fluxes, flux radii and observable dust masses in protoplanetary discs, in order to understand how these depend on the angular momentum budget and on the assumed heat sources. We use a model that includes the formation and viscous evolution of protoplanetary gas discs, together with the growth and radial drift of the dust component. We find that we
Main conclusion: Chloroplast protein transport depends on the SEC1 translocase. Barley xan-m mutants, deficient in SECA1, lack chlorophyll and die as seedlings. Their yellow phenotype indicates that carotenoid chemistry is less SEC1-dependent. Chloroplast proteins encoded by genes located in the cell nucleus need to be transported across up to three chloroplast membranes to find its correct locati
Water flows through time are connected to specific instances of socionatural and sociotechnical assemblages of human and non-human components. We propose the concept of “water palimpsest” in order to characterize the complex histories of chemical and metabolic alterations embodied in water flows, potentially disruptive for humans and other living beings. Through the concept of palimpsest we interp
At the intersection of natural and social sciences, interest in river sedimentary fluxes and their alteration by human activities is increasing in the context of general retreat of delta formations. Since the 1950s, the construction of large dams in the main course of rivers has produced, among other impacts, a radical decrease in sedimentary fluxes — a key factor in the worldwide sedimentary cris
In the context of the space race, space science became an area of collaboration between the Spanish dictatorship and the United States of America during the 1960s. The Francoist regime leveraged its collaboration in the space race as an internal tool for political legitimization. This article examines the role of science popularization in this legitimization process by focusing on the TV show Amig
Drawing on a range of previously unused data to construct a data series of practically every strike in the US automotive industry from 1946-2002, this paper examines the changing relationship between strikes and wage determination in the post-war period. Drawing on the historical concept of the ‘labour-capital accord’ this study undertakes analysis on two sub-periods, 1946-1981 and 1982-2002. Thro
Following five decades of isolation and ruthless military rule, Myanmar authorities started implementing various nominally democratic reforms. In response to these developments Western governments scaled back sanctions that had made the country anathema to foreign business. Writing within premises of late modernity, and the retreat of the state as primary political-geographical reference, this the
Recent years have seen an increase in reports on rising wildfire occurrences in countries of the Middle East. Wildfires are integral parts of terrestrial ecosystems and as such prone to the recent, large-scale anthropogenic changes of global ecosystem dynamics. However, the systematic analysis of patterns of wildfire occurrences – fire regimes – is concentrated on a few well studied regions and re
This article analyses how a newly established set of actors – online brokerage firms (OBFs) – sought to popularise stock trading among the Swedish populace in the late 1990s. During this period, internet usage took off and stock markets surged rapidly up until the dotcom bubble burst in 2000. Sweden was at the forefront of both these international developments, and we analyse the intimate connecti
Radicalization is most often seen as a gradual process that may or may not lead to radical or extreme behaviors such as terrorism. Theories on the radicalization process often highlight the potential role of social exclusion in the propensity for radicalization. We here present some of the major radicalization theories and discuss exclusion as a common denominator that could trigger a radicalizati
