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Inflammatory mediators are important in traumatic brain injury (TBI). The objective of the present study was to investigate the expression of cyclooxygenase-2 (COX-2), prostaglandin E (PGE) and PGD synthases, and PGH2 metabolism in two rat models of TBI. Fluid percussion injury (FPI) resulted in bilateral induction of COX-2 mRNA in the dentate gyri and the cortex, whereas controlled cortical contu
von Willebrand factor (VWF) levels in healthy individuals and in patients with type 1 von Willebrand disease (VWD) are influenced by genetic variation in several genes, for example, VWF , ABO and STXBP5 . Here, we comprehensively screen for STXBP5 variants and investigate their association with type 1 VWD in Swedish patients and controls. The coding region of the STXBP5 gene was re-sequenced in 10
We study a system of spherical non-adsorbing particles immersed in a polydisperse polymer fluid. We derive an analytic expression for the many-body depletion interactions between the colloidal particles in the limit of very long chains. We argue that this expression is essentially exact for long chains and justify this using explicit simulations. In this way we are able to elucidate the profound e
A kinematically complete experiment on two-photon double ionization of Ar by free-electron laser radiation with a photon energy of 27.93 eV was performed. The electron energy spectra show that double ionization is dominated by the sequential process. Comparison of the electron angular distributions to our data for single ionization and to theory confirms that even in the sequential process the ele
This study documents the early post-embryonic developmental stages (protaspides and early meraspides) of the Cambrian trilobite Ellipsostrenua granulosa (Ahlberg, 1984) from the Gärdsjön Formation of Jämtland, Sweden. The early protaspid stage is characterized by a circular outline of the exoskeleton, two pairs of fixigenal spines, a short preglabellar field, a genal swelling, and prominent bacull
Correct phenotypic interpretation of variants of unknown significance for cancer-associated genes is a diagnostic challenge as genetic screenings gain in popularity in the next-generation sequencing era. The Critical Assessment of Genome Interpretation (CAGI) experiment aims to test and define the state of the art of genotype-phenotype interpretation. Here, we present the assessment of the CAGI p1
Transforming growth factor-beta (TGF-beta) enhances the production of extracellular matrix components, such as type I and type III collagen, fibronectin, proteoglycans, in various cell types. The effect on hyaluronan synthesis in relation to proteoglycan synthesis has not been investigated. Human lung or skin fibroblast cultures were treated with TGF-beta in serum-free medium for various periods o
Based on fieldwork among jade traders and carvers in Ruili, this chapter discusses the realization of economic and spiritual potentials of a type of jade called feicui翡翠 as determination of a partially indeterminate material. Some traders posit feicui as an empty container for economic value, while the material constitutes spiritual fullness especially for carvers. An opaque layer of surface skin
The reconstruction of the signal from hadrons and jets emerging from the proton–proton collisions at the Large Hadron Collider (LHC) and entering the ATLAS calorimeters is based on a three-dimensional topological clustering of individual calorimeter cell signals. The cluster formation follows cell signal-significance patterns generated by electromagnetic and hadronic showers. In this, the clusteri
The main objective was to locate QTL and estimate the proportion of total genetic variance attributable to quantitative trait loci (QTL) for production index traits and the udder health index identified on six Bos taurus autosomes in the Danish Holstein dairy cattle population. Data were obtained from a granddaughter design of 20 sire families with a total of 1 869 progeny tested sons. The number
With the increase in energy of the Large Hadron Collider to a centre-of-mass energy of 13 TeV for Run 2, events with dense environments, such as in the cores of high-energy jets, became a focus for new physics searches as well as measurements of the Standard Model. These environments are characterized by charged-particle separations of the order of the tracking detectors sensor granularity. Basic
The overall kinetics for manganese(II/III) catalyzed autoxidation of dissolved sulfur dioxide has been studied by UV-vis spectrophotometry. A free-radical mechanism has been proposed, and the rate constant for one of the key reactions between manganese(II) and peroxomonosulfate has been determined by pulse radiolysis. Previous literature on manganese catalyzed autoxidation of SO2(aq) has been thor
Background and Purpose - A patent foramen ovale (PFO) is disproportionately prevalent in patients with cryptogenic stroke. Without alternative explanations, it is frequently considered to be causative. A detailed stratification of these patients may improve the identification of incidental PFO. Methods - We investigated the PFO prevalence in 3497 transient ischemic attack and ischemic stroke patie
Infectious diseases remain a major health problem, and sepsis and other severe infectious diseases are common causes of morbidity and mortality. There is a need for clinical and laboratory tools to identify patients with severe infections early and to distinguish between bacterial and nonbacterial conditions. Heparin-binding protein (HBP), also known as azurocidin or cationic antimicrobial protein
Background: Phylogeny construction can help to reveal evolutionary relatedness among molecular sequences. The spike (S) gene of SARS-CoV-2 is the subject of an immune selective pressure which increases the variability in such region. This study aimed to identify mutations in the S gene among SARS-CoV-2 sequences collected in the Middle East and North Africa (MENA), focusing on the D614G mutation,
Metastatic castration-resistant prostate cancer is today incurable. Conventional imaging methods have limited detection, affecting their ability to give an accurate outcome prognosis, and current therapies for metastatic prostate cancer are insufficient. This inevitably leads to patients relapsing with castration-resistant prostate cancer. Targeting prostate-specific antigens whose expression is c
We used Raman spectroscopy to investigate phonon modes of single InP-InAs core-shell nanowire with a pure wurtzite phase to reveal the embedded strained state. Raman spectra show that the InP core exhibits tensile strain and the InAs shell exhibits compressive strain due to the radial heterostructure growth. Using different polarization excitation configurations, we identified distinct A1 (TO) and
