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For effective clinical management of patients being treated with 223Ra, there is a need for radiographic response biomarkers to minimize disease progression and to stratify patients for subsequent treatment options. The objective of this study was to evaluate an automated bone scan index (aBSI) as a quantitative assessment of bone scans for radiographic response in patients with metastatic castrat
The problem investigated in this paper is the one of finding the optimal combination of inventory and options in a stationary multi-period problem with an infinite horizon. The research complements existing literature as it considers the combination of option and wholesale contracts. The paper show how the problem can be transformed to a combination of newsvendor type problems. This alternative in
Identification of biomarkers associated with protection from developing diabetic complications is a prerequisite for an effective prevention and treatment. The aim of the present study was to identify clinical and plasma metabolite markers associated with freedom from vascular complications in people with very long duration of type 1 diabetes (T1D). Individuals with T1D, who despite having longer
For the CSR movement the challenge is broadly speaking to make responsible business practices both effective and sustainable in the long run, communicate them credibly to third parties, and institutionalise them more widely in the business community. In this article, I address three main themes where I think more clarity would enable CSR to evolve to a new level and achieve its promising potential
This paper analyses the influence of marketing and organisational changes on the innovation process. Using data from the German community innovation survey 2007, two topics are investigated: First, we analyse whether firm and market characteristics trigger certain innovation strategies. Second, this paper investigates whether marketing and organisational innovations (MO innovations) are complement
My paper begins with some brief observations on the existing literature on the Chinese Communist Party’s post-Mao reversal of so-called unjust, wrong, and false cases. The paper then proceeds to examine a noteworthy difference between the PRC case and transitional justice in other states where “the transitional” entailed a further shift in power from an ancien regime to an entirely new order (viz.
Many cells express receptors for plasminogen (Pg), although the responsible molecules in most cases are poorly defined. In contrast, the group A streptococcal surface protein PAM contains a domain with two 13-amino acid residue long repeated sequences (a1 and a2) responsible for Pg binding. Here we identify the region in Pg that interacts with PAM. A radiolabeled proteolytic plasminogen fragment c
Full-cycle simulations of a spark ignition engine running on a primary reference fuel have been performed using a two-zone model. A detailed kinetic mechanism is taken into account in each of the zones, while the propagating flame front is calculated from a Wiebe function. The initial conditions for the unburned gas zone were calculated as a mixture of fresh gas and rest gas. The composition of th
