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This work proposes methodologies using a model-based approach to gain knowledge on and assist the development of an ion-exchange step in a protein purification process; the separation of IgG from a mixture containing IgG, insulin and transferrin. This approach is suitable for capture and intermediate steps in a process. Both methods involve four consecutive steps. Firstly, the retention of the dif
Phthalates, a class of chemicals used as plasticizers, are economically important due to several industrial applications. Di-(2-ethylhexyl) phthalate (DEHP) is the most commonly used phthalate plasticizer, and it has been described as a potent antiandrogen in males. In this study, lactating dams were exposed via oral gavage to corn oil (vehicle) and DEHP (1, 10, and 100 mg/kg body weight) from pos
The climate impacts from bioenergy involve an important time aspect. Using forest residues for energy may result in high initial emissions, but net emissions are reduced over time since, if the residues were left on the ground, they would decompose and release CO2 to the atmosphere. This article investigates the climate impacts from bioenergy with special focus on the time aspects. More specifical
A possible downstream effect of high in-hospital bed occupancy is that patients in the emergency department (ED) who would benefit from in-hospital care are denied admission. The present study aimed at evaluating this hypothesis through investigating associations between in-hospital bed occupancy at the time of presentation in the ED and the probability for unplanned 72-hour (72-h) revisits to the
Summary Approximately 10% of the patients diagnosed with type 2 diabetes (T2D) have detectable serum levels of glutamic acid decarboxylase 65 autoantibodies (GADA). These patients usually progress to insulin dependency within a few years, and are classified as being latent autoimmune diabetes in adults (LADA). A decrease in the frequency of peripheral blood natural killer (NK) cells has been repor
The outcome of catheter ablation (CA) of atrial fibrillation (AF) is vastly analyzed by the entire P-wave duration (PWD). However, the first and second P-wave parts, corresponding to right (RA) and left atrial (LA) wavefront propagation, may be unequally modified. Five-minute lead II recordings before and after the first-ever CA of 40 parox-ysmal AF patients were analyzed and P-wave features were
The building sector is facing a challenge in achieving carbon neutrality due to climate change and urbanization. Urban building energy modeling (UBEM) is an effective method to understand the energy use of building stocks at an urban scale and evaluate retrofit scenarios against future weather variations, supporting the implementation of carbon emission reduction policies. Currently, most studies
In our meta-study from 2022, “A Literature Review and Meta-Analysis of the Effects of Lockdowns on COVID-19 Mortality – II,” we find that the effect of lockdowns—also referred to as ‘Covid restrictions,’ ‘social distancing measures,’ etc.—on mortality was negligible. The first version of our meta-study received criticism from Banholzer, et al. (2022). The authors raised “concerns regarding the sub
The United Nations Sustainable Development Goals (SDGs) include social and ecological goals for humanity. Navigating towards reaching the goals requires the systematic inclusion of perspectives from a diversity of voices. Yet, the development of global sustainability pathways often lacks perspectives from the Global South. To help fill this gap, this paper introduces a participatory approach for v
Generation of food waste (FW) continues to be a global challenge and high on the political agenda. One of the main reasons for its generation is the absence of detailed data on the amount, timing and reasons for created waste. This paper discusses the design, the application and investigates the Internet of Things (IoT) based FW monitoring system to capture waste data during manufacturing in real-
While prior research has gleaned important insight into consumers’ social media engagement, an important literature-based tension exists that warrants further attention. On the one hand, females are increasingly empowered (e.g., through their rising spending power). On the other hand, advertising-based gender stereotypes persist, thus limiting female consumers’ empowerment and decelerating adverti
BACKGROUND: Autoantibodies are common in glomerulonephritis, but the clinical benefit of rapid elimination is not determined, even in anti-glomerular basement membrane (GBM) disease. Even less is known about the importance of autoantibody characteristics, including epitope specificity and IgG subclass distribution. By utilizing samples from the GOOD-IDES-01 trial, where imlifidase, cleaving all Ig
Popular Abstract in Swedish Vid framtagning av nya produkter måste man utgå ifrån de behov som den blivande kunden ställer i form av krav och önskemål på produkten för att den ska vara intressant att inhandla och använda. För att säkerställa att den blivande produkten har de egenskaper som efterfrågas, används idag omfattande simuleringar av den blivande produktens egenskaper. Simuleringar består The current trend in industry to encourage engineering designers to take an active part in the analysis of their own design solutions is apparent in many companies today, domestically as well as abroad. From a research project with the objective to develop a computer-based design system for the design of lightweight grippers, one of the major difficulties was to overcome the system users’ lack of
A description of general models for adsorption kinetics is given. Combinations of the models are compared with adsorption data for the self-associating proteins β-lactoglobulin A and B, from Elofssonet al.(U. M. Elofsson, M. A. Paulsson, and T. Arnebrant,Langmuir,submitted). The adsorption onto methylated silica surfaces was measured by these authors by ellipsometry in phosphate buffer (0.01M,pH 7
This report provides a brief review of how national government policies and guidelines apply to or regulate the use of environmental labelling and information schemes (ELIS) in selected OECD countries. The report reviews definitions relevant to environmental claims and identifies four types of potentially false or misleading environmental claims. The report also reviews countries’ different approa
BACKGROUND: The aim of this study was to evaluate the feasibility and efficacy of a modified delivery system of the distal bifurcated FEVAR component where the dilator tip was shortened to prevent damage to the renovisceral bridging stents.METHODS: All consecutive patients from a tertiary referral center that underwent a FEVAR with a custom delivery system of the distal bifurcated endograft with a
