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Popular Abstract in Swedish Människans utveckling och fysiologiska anpassning till upprätt kroppställning är beroende av en rad blodtrycksreglerande mekanismer. Vid ortostatisk hypotension sjunker blodtrycket i samband med uppresning från liggande till stående. Detta beror på en sviktande cirkulationsanpassning så att organismen inte förmår att upprätthålla ett tillräckligt högt blodtryck. SymtomeOrthostatic hypotension (OH) is believed to be an important cause of cerebral hypoperfusion, leading to chronic fatigue, blurred vision, unsteadiness, dizziness and sometimes syncope. It may also result in episodes of confusion, falls and fractures. The coupling between OH and organic dementia is not clear. Our findings in a large group of patients with Alzheimer's disease, vascular- and frontotem

Aerosol particles in the atmosphere are important in several aspects. Some major aerosol constituents that are deposited in ecosystems are acidic or fertilisers and some minor or trace constituents are toxic. Aerosol particles are also involved in the earth’s radiation balance, both directly by scattering the sunlight and indirectly by influencing the clouds. All these effects are influenced by th

This thesis focuses on the possibilities to reduce fouling by 1.Modifying the stainless steel surface. For this purpose, surfaces modified with state-of-the-art material science techniques, such as SiF3+ and MoS22+ ion implantation, Diamond-like Carbon (DLC) sputtering, DLC, DLC-Si-O and SiOx Plasma Enhanced Chemical Vapour Deposition (PECVD), autocatalytic Ni-P-PTFE and silica coating, have been

Two flavones, 4',5,7-trihydroxy-6-methoxy flavone (dinatin) and 4',5-dihydroxy-6, 7-dimethoxy flavone (skrofulein), were extracted from Artemisia herba alba L. Dinatin and skrofulein inhibited the binding of [methyl-3H]diazepam to rat brain membranes in vitro with IC50 of 1.3 and 23 mumol.L-1, respectively. The GABA-ratios (the ratio of IC50 values in the absence/presence of GABA in the binding as

Objective: To investigate the association between human herpesviruses and multiple sclerosis ( MS), as well as between measles virus and MS. Methods: The authors identified prospectively collected serum samples from 73 MS cases and retrospective sera from 161 MS cases in two population-based serum bank registers. Analyses of IgG antibody responses in cases and matched referents were performed for

A prospective study of posttransfusion non-A, non-B hepatitis was conducted in Malmo, Sweden, in 1984-1985, in which donors were alanine aminotransferase (ALT) screened but not ALT selected. Among 741 patients studied at 0, 6, and 12 weeks after transfusion, 13 developed non-A, non-B hepatitis, and these were further followed up. Stored sera from the 13 hepatitis patients and their 123 donors were

A comparison is made between the development trends experience over the last decades by the steel and papermaking industries, respectively. These two industrial branches, although totally different in their technical nature, are subject to similar pressures from their external environment, notably increasing requirements for environmental protection and more efficient raw material management. Such

We complete here our work on isospin violation in the K -> 3 pi system. We first calculate K -> 2 pi to the same order as we did K -> 3 pi in papers I and II of this series. This adds the effects of order G(27)p(2)(m(u) - m(d)) and G(27)p(2)e(2) to earlier work. We calculate also the lowest order bremsstrahlung contributions, K -> 2 pi gamma, 3 pi gamma. With these and our earlier results we perfo

This thesis consists of two parts with the common theme of statistical modelling in chemistry. The first part is concerned with applications in nuclear magnetic resonance (NMR) spectroscopy, while the second part deals with applications in polymerase chain reaction (PCR). The problems considered in the first part all have their origin in protein NMR spectroscopy, although they are treated mainly

BACKGROUND: Data from several studies support the hypothesis that thrombopoietin (TPO) plasma levels are regulated via circulating platelet (PLT) numbers by binding to PLT TPO receptors (TPO-Rs). In this study, PLT numbers and TPO plasma levels were measured following the transfusion of unmanipulated, sham-saturated, and TPO-R-saturated PLT preparations to provide additional in vivo evidence for t

Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the 0 cells in the pancreas are destroyed by the body's own immune system. IL12 plays a role in pathological situations, such as septic shock, tissue damage during inflammation, and organ-specific autoimmune diseases. In NOD mice, administration of IL12 induces T1DM and administration of IL12 antagonists prevents T1DM. Linkage and a

BACKGROUND: Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP)-containing nerves surround cerebral blood vessels. The peptides have potent vasodilator properties via smooth muscle cell receptors and activation of adenylate cyclase. The purpose of this study was to describe the effects of two putative VIP/PACAP receptor antagonists and the distribution of