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Human alpha-lactalbumin made lethal to tumor cells (HAMLET) is a complex formed by human alpha-lactalbumin and oleic acid that displays tumoricidal activity but does not kill healthy, differentiated cells. As the sequence of alpha-lactalbumin is conserved among mammals, lactalbumins from other species are expected to form oleic acid complexes with similar activity. This study investigated the tumo
This thesis investigates occupant evacuation in basement carparks. The thesis aims to develop a calculation model to determine the probability of different number of doors to fire-isolated stairs being open simultaneously during an evacuation scenario. Research is done on previous studies of occupant evacuation, including the pre-evacuation and evacuation phase, which is the base for a conceptual
Mitochondria are the main organelles in eukaryotic cells involved in energy production together with their role in other mechanisms including intermediate metabolism, calcium signaling and apoptosis. Due to their importance in the correct function of the cell, genetic mitochondrial disorders can present a wide variability of symptoms, such as epilepsy, skeletal and cardiac myopathy and intellectua
Uppmärksamhetsbias har föreslagits vara involverat i både utveckling och vidmakthållande av tvångs- och ångestsyndrom. Befintlig forskning har emellertid genererat motsägelsefulla resultat och forskning avseende barn och ungdomar är begränsad, särskilt relaterat till tvångssyndrom. Vidare finns det ingen studie där uppmärksamhetsbias har undersökts i relation till Core Dimension Modellen (SummerfeBiased attentional processes have been implicated in the development and maintenance of anxiety disorders (ADs) and obsessive-compulsive disorder (OCD). However, existing research has yielded inconsistent results and there is limited research with samples of children and adolescents, especially in relation to OCD. Further, there is no study examining attentional bias connected to the Core Dimensio
Detta examensarbete utforskar integrationen av metoder för att bedöma klimatpåverkan inom investeringsprocesser hos energiföretag, med särskilt fokus på E.ON i Sverige. Vikten av att ta itu med ökande klimatförändringar har intensifierats, vilket kräver en transparent och effektiv strategi för företag för att minska sin miljöpåverkan från investeringar. Denna studie syftar till att identifiera, utThis master thesis explores the integration of climate impact assessments within the investment processes of energy companies, with a specific focus on E.ON in Sweden. The urgency to address climate change has intensified, necessitating transparent and effective strategies within corporate investment decisions to mitigate environmental impact. This study aims to bridge the gap between theoretical
NASA's GPM satellite rainfall products IMERG early run and IMERG late run were evaluated for their applicability in flash flood forecasting. The selected catchment was the upper Han River basin, a mountainous catchment with low precipitation in winter and heavy precipitation during summers located in central China. The evaluated period spanned from 2015-03 to 2016-03 and is limited by the IMER
In this paper, it is going to discuss community building in local China by exploring peculiarity of the phenomenon of gendered staff of local community. It argues that the feature of gendered staff is a reflection of the function of local community and the more advanced of the function of local community the less of the feature of gendered staff. Additionally, the function shift of local community
The idea of energy efficient, healthy buildings has existed since 1970s. However, a one-dimensional approach for many housing issues does not assure sustainability. Therefore, near the end of the 20th century, the built environment became a focus of attention within the environmental movement with wider focus on building certification schemes and sustainability issues such as interrelationships be
To avoid discomfort, health care professionals may hesitate to pursue conversations about end of life with patients. Certain tools have the potential to facilitate smoother conversations in this matter. The objective was to explore the experiences of patients in palliative care in using statement cards to talk about their wishes and priorities. Forty-six cards with statements of wishes and priorit
Background: Hypoxia-inducible factor (HIF)-2α associates with poor outcome in neuroblastoma and glioblastoma, and gain-of-function mutations in the EPAS1 gene (encoding HIF-2α) have been reported in paragangliomas and pheochromocytomas. Specific targeting of a druggable hydrophobic pocket in the HIF-2α PAS-B domain with PT2385 have demonstrated promising clinical results for clear cell renal cell
Selenium is an essential micronutrient for many organisms, and in vertebrates has a variety of roles associated with protection from reactive oxygen species. Over the past two decades there have been conflicting reports upon human health benefits and detriments arising from consumption of selenium dietary supplements. Thus, early studies report a decrease in the incidence of certain types of cance
Sociodemographic factors and lifestyle habits affect body weight and body composition. A new syndrome, called normal-weight obesity (NWO), is found in individuals with normal weight and excess body fat in contrast to lean and overweight individuals. The aim of the present study was to explore the associations between sociodemographic factors and smoking and alcohol habits and lower versus higher B
Packaging developers in the food industry must consider several, sometimes conflicting, environmental requirements on packaging along with an already complex combination of marketing, logistics and production requirements. Existing methods for the environmental evaluation of packaging either focus on a limited amount of environmental packaging criteria (such as recyclability or renewable content)
Neuroscience focusing on human development and disease has long been hampered due to ethical reasons, low tissue availability, and low translatability from animal models. To circumvent these obstacles, we have developed two methods for the investigation of human neural cells in culture. Firstly, we present a robust 2-week protocol for the differentiation of human pluripotent stem cells (PSCs) into
Brexit and the ensuing uncertainty about the United Kingdom’s (UK’s) future relationship with the European Union (EU) have brought the participation of non-EU Member States in the internal market to the centre of academic attention. The latter phenomenon is not novel and many of the existing frameworks for cooperation between the EU and its neighbourhood countries have been used as models for a po
AIMS: Improved risk stratification is of value for decision making in pulmonary arterial hypertension (PAH). Right heart catheterization combined with quantitative tricuspid regurgitation (TR) by cardiovascular magnetic resonance (CMR) may provide this. The aims were to study: (i) to what extent quantitative TR is associated with event-free survival; (ii) how quantitative TR is related to known pr
Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene in 13q12.2 are among the most common driver events in acute leukemia, leading to increased cell proliferation and survival through activation of the PI3K/AKT, RAS/MAPK and STAT5 signaling pathways. In this study, we examine the pathogenetic impact of somatic hemizygous 13q12.2 microdeletions in B-cell precursor acute lymphoblastic leukemia (B
