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The urban square has been a distinguishing characteristic of European cities for millennia. However, in the context of small towns, where the square is often the sole identifier of their physical urbanity, its role differs from that of large towns. This fact is substantial within national administrative systems that endorse desirable urban status to rural settlements endowed with urban morphology.
Background: KIT mutations are the predominant driver mutations in gastrointestinal stromal tumors (GISTs), and targeted therapy against KIT has improved treatment outcome dramatically. However, gaining secondary mutation of KIT confers drug resistance of GISTs leading to treatment failure. Results: In this study, we found that secondary mutation of KIT dramatically increases the ligand-independent
Extensive genetic and epigenetic variegation has been demonstrated in many malignancies. Importantly, their interplay has the potential to contribute to disease progression and treatment resistance. To shed light on the complex relationships between these different sources of intra-tumour heterogeneity, we explored their relative contributions to the evolutionary dynamics of Acute Lymphoblastic Le
Scientific breakthroughs in the field of cell and gene therapy lay the groundwork for therapeutic innovation, but their translation and integration into routine care is delayed by systemic inefficiencies and limited cross-sector alignment. The Advanced Therapies model of Lund is a proactive and integrated approach designed to accelerate the development of advanced therapies from discovery to reimb
Background: The evidence-based Canadian Adult Obesity Clinical Practice Guideline (CPG) released in August 2020 were developed through a systematic literature review and patient-oriented research process. This CPG is considered a paradigm shift for obesity care as it introduced a new obesity definition that is based on health not body size, incorporates lived experiences of people affected by obes
Malnutrition-Related Diabetes Mellitus (MRDM) is a subtype of diabetes associated with chronic malnutrition, primarily observed in low- and middle-income countries (LMICs) and impoverished populations. The disease is characterized by onset in young, lean patients with a history of chronic undernutrition, insulin deficiency, persistent insulin sensitivity, and resistance to ketosis. MRDM was recogn
Development organisations that work to transform gender relations and power structures are bound to face resistance to change (RTC). While overt forms of RTC are becoming increasingly prominent in the context of the rise of the transnational «anti-gender» movement. Thus, this thesis aims to understand how RTC can be addressed through a gender-transformative approach (GTA) by focusing on the case s
Lifejackets, categorized as personal protective equipment, are subject to meticulous regulation. In Europe, the commercialization of a lifejacket necessitates its compliance with various requirements, notably the successful completion of field tests. The objective of this project is to digitally recreate the primary tests employed for product validation. The numerical simulation employs the child
This thesis attempts to study and explain Swedish school principals’ reactions to and perceptions of the auditing process of the Swedish School Inspectorate. Guided by two strands of institutional theory, rational choice and sociological institutionalism, the author identifies certain factors that can potentially affect how principals react and think about the auditing process. The study follows a
I Sverige vänds omkring 50.000 barns liv upp och ner varje år, när deras föräldrar väljer att gå skilda vägar. Det som en gång varit barnets trygghet och hela värld, rivs upp och känns istället skrämmande och otryggt. Föräldrarnas viljor och känslor styr processen, vilket gör att barnen allt som ofta hamnar i kläm. I en majoritet av fallen löser föräldrarna barnets boende, vårdnad och umgänge gemeIn Sweden the lives of about 50.000 children are turned upside down every year, just because their parents have choosen to separate. What has once been the childs secure and safe world, are now ripped apart and frightening instead. The wills of the parents and their emotions, can greatly impact the decisions of the jucidial process which can in turn have a catasprohic backlash on the child. In the
Photoacoustic imaging can potentially map oxygen saturation (sO2) non-invasively. However, in-vivo human application is challenging due to spectral coloring, which causes a wavelength-dependent fluence attenuation and uncertainty in the estimation of chromophore concentrations deep in tissue. This study compares the performances of two previously proposed methods for spectral coloring compensation
The work presented in this dissertation is dedicated to the characterization of the excited state dynamics of thin films through time-resolved spectroscopy, with emphasis on developing a methodology that is able to resolve weak transient absorption signals from optically thin films. With this aim, the conventional transient absorption spectroscopy method is first utilized to characterize semicondu
This study explores how the emergence of unmanned stores impacts the sense of community in rural areas. It is set against the backdrop of increased urbanization, which threatens the survival of smaller rural communities. We study this through ethnographic inquiry into the emergence of unmanned stores. These have been introduced to counteract the depopulation of rural areas. We identify four ways i
Key questions for understanding hippocampal function in memory and navigation in humans are the type and source of visual information that reaches the human hippocampus. We measured bidirectional pairwise effective connectivity with functional magnetic resonance imaging between 360 cortical regions while 956 Human Connectome Project participants viewed scenes, faces, tools, or body parts. We devel
Antibody–enzyme complexes (AECs) are ideal for immunosensing. Although AECs using antibody fragments can be produced by bacterial hosts, their low affinity limits their sensing applications. We have improved the affinity of AECs by combining two antibodies using Catcher/Tag systems; however, it requires multiple antibodies and an enzyme production process. In this study, to realize the production
