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Chondroadherin, a leucine-rich repeat family member, contains a very C-terminal sequence CKFPTKRSKKAGRH(359), now shown to bind to heparin with a K-D of 13 mu M. This observation led us to investigate whether chondroadherin interacts via this C-terminal heparin-binding domain with glycosaminoglycan chains of proteoglycans at the cell surface. Cells were shown to bind this heparin-binding peptide i
The Umkondo Large Igneous Province (LIP) is represented by widespread (similar to 2.0 x 10(6) km(2)) mafic intrusions that were rapidly emplaced (1112-1108 Ma) into the Kalahari craton of southern Africa and the formerly adjacent Grunehogna Province of Antarctica during Rodinia assembly. Very few Umkondo-aged dykes have been identified before, resulting in a poor understanding of this LIP's plumbi
Accumulating studies, both in animals and human clinical trials with mesenchymal stroma cells (MSC) support the hypothesis of therapeutic effects of these cells in various disorders. However, despite success in immune-mediated disorders such as Crohns' disease, lung disorders such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary disease (IPF) treated with MSC have so far no
Half of the biological activity in forest soils is supported by recent tree photosynthate, but no study has traced in detail this flux of carbon from the canopy to soil microorganisms in the field. Using (CO2)-C-13, we pulse-labelled over 1.5 h a 50-m(2) patch of 4-m-tall boreal Pinus sylvestris forest in a 200-m(3) chamber. Tracer levels peaked after 24 h in soluble carbohydrates in the phloem at
Objective: Lymphocyte recirculation constitutes an integral part of the adaptive immune system. Blood-borne lymphocytes migrate into secondary lymphoid organs, crossing the vascular wall of site-specific high endothelial venules (HEVs). We created a preparation of the cervical lymph node in mice to study lymphocyte homing in vivo. Methods and Results: Our novel approach allowed the detailed analys
The aim of this study was to determine the role of Magnetic Resonance Imaging (MRI) in investigating fetal cerebral lesions induced by long term exposure to cocaine during sheep pregnancy. Cerebral Magnetic Resonance Imaging was performed on two groups of fetuses at 125 days of gestation (normal gestation: 145 days). The control group consisted of eight fetuses of four pregnant ewes. The study gro
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the inability to initiate, execute and control movement. Neuropathologically, there is a striking loss of dopamine-producing neurons in the substantia nigra pars compacta, accompanied by depletion of dopamine in the striatum. Most forms of PD are sporadic, though in some cases familial inheritance is observed. In
The vitamin K-dependent anticoagulant protein S binds with high affinity to C4b-binding protein (C4BP), a regulator of complement. Despite the physiological importance of the complex, we have only a patchy view of the C4BP-binding site in protein S. Based on phage display experiments, protein S residues 447-460 were suggested to form part of the binding site. Several experimental approaches were n
Smoluchowski's coagulation equation is studied for the kernel K (u, v) = E(u(alpha)v(beta) + u(beta) v(alpha)) with real, non-negative alpha, beta and E, using gamma distributions with a singularity at zero volume as initial size spectra. As the distribution parameter of the gamma distribution, p, approaches its lower limit (p -> 0) the distribution becomes similar to pv(p-1) 1 for small v. Asympt
Syftet med den här studien var att undersöka ChatGPTs förmåga att uppskatta nivåer av depression och ångest. ChatGPT blev genom en prompt instruerad att uppskatta en deltagares nivå av depression och ångest, baserat på deltagarnas svar på öppna frågor om deras symptom de senaste två veckorna. Totalt inkluderade studien ordresponser från 876 deltagare. Uppskattade poäng från ChatGPT jämfördes med dThe aim of this study was to explore the accuracy of ChatGPT’s numeric assessments of depression and anxiety. ChatGPT was prompted to estimate participants’ levels of depression and anxiety using the participants’ responses to an open-ended question about their symptoms during the past two weeks. In total, the study included responses from 876 participants. Estimated scores were compared to scores
In this study the willingness to pay and conformity-seeking behaviour of Swedish consumers when purchasing fair trade coffee were examined. It was conducted through a conjoint analysis on data collected from two different questionnaires; one that presented objective information on fair trade, and one that linked fair trade to aspirational cues. The results indicated that ethical claims of fair tra
Worldwide plastic production is expected to reach an amount of 34 billion tons by 2050, and a large portion of plastic used is for single-use packaging and low-cost consumer plastic products that are discarded. It is important to have a path to a circular economy by recycling and producing locally. The following potential research questions were identified to contribute to the existing knowledge i
Development organisations that work to transform gender relations and power structures are bound to face resistance to change (RTC). While overt forms of RTC are becoming increasingly prominent in the context of the rise of the transnational «anti-gender» movement. Thus, this thesis aims to understand how RTC can be addressed through a gender-transformative approach (GTA) by focusing on the case s
Lifejackets, categorized as personal protective equipment, are subject to meticulous regulation. In Europe, the commercialization of a lifejacket necessitates its compliance with various requirements, notably the successful completion of field tests. The objective of this project is to digitally recreate the primary tests employed for product validation. The numerical simulation employs the child
This thesis attempts to study and explain Swedish school principals’ reactions to and perceptions of the auditing process of the Swedish School Inspectorate. Guided by two strands of institutional theory, rational choice and sociological institutionalism, the author identifies certain factors that can potentially affect how principals react and think about the auditing process. The study follows a
This report describes the development of a new fixing process when attaching a sensor PCB card to a camera assembly. The thesis focused on cameras which requires calibration to find the optimal position of the sensor PCB card, a process called active alignment. The development process applied for this thesis was derived from the Generic Development Process by Ulrich and Eppinger. Interviewees wit
The aim of this study was to collect new knowledge about the importance of signal crayfish predation on zebra mussels in Lake Erken. Possibly with implications on biological control of the invasive species in Swedish lakes. I performed a field experiment with enclosures (including signal crayfish) and exclosures (without signal crayfish) during 11 summer weeks in Lake Erken. My results showed that
Föroreningar på en fastighet berör fastighetsägaren på olika sätt. En direkt effekt av föroreningarna kan vara att fastighetsägarens möjligheter att använda marken begränsas och att värdet på fastigheten påverkas. Det kan också få till följd att fastigheten blir svår att avyttra. Framförallt kan en förorening på fastigheten innebära att fastighetsägaren riskerar miljörättsliga krav på att vidta avPollution of real estate affects the owner in different ways. As a direct effect, the possibilities of using the land may be limited, and the value of the real estate can be influenced. The real estate may also be difficult to sell. Above all, pollution of real estate may involve environmental legal demands on the owner to repair the damage. The main rule of the Swedish environmental code is that
