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The aim of this study was to identify characteristics of temporal patterns of daily occupations that could be related to high and low subjective health among older adults in Northern Sweden. A cross-sectional design imprinted by time-geographic methodology was used and participants 70 years and older were purposively selected and divided into groups of high and low health using the SoC-29 and SF-3
We present a study of tail-bias-current 1/f noise upconversion into 1/f(3) phase noise for both CMOS Colpitts and differential-pair LC oscillators. We focus on the incremental Groszkowski effect, i.e., the modulation of the shift in oscillation frequency induced by the higher current harmonics flowing into the LC tank of a harmonic oscillator induced by bias instabilities, as we show that there is
Type 2 diabetes carries a risk for hypoglycemia, particularly in patients on an intensive glucose control plan as a glucose-lowering strategy, where hypoglycemia may be a limitation for the therapy and also a factor underlying clinical inertia. Glucose-lowering medications that increase circulating insulin in a glucose-independent manner, such as insulin and sulfonylurea therapy, are the most comm
Context: Postprandial glucose homeostasis is regulated through the secretion of glucagon-like peptide 1 (GLP-1) through stimulation of insulin secretion and inhibition of glucagon secretion. However, how these processes dynamically adapt to demands created by caloric challenges achieved during daily life is not known. Objective: To explore adaptation of incretin and islet hormones after mixed meal
Many animals can use the polarization of light in various behavioural contexts. Birds are well known to use information from the skylight polarization pattern for orientation and compass calibration. Still, there are few controlled studies of polarization vision in birds, and the majority of them have not been successful in convincingly demonstrating polarization vision. We used a two-alternative
Persistent organic pollutants (POPs) and heavy metals are well known environmental pollutants. Even though numerous studies have been carried out to assess human exposures to these compounds, there is still a lack of data on humans from developing countries, especially in underprivileged children. The objective of this study was to assess the exposure to POPs and heavy metals in children from Dhak
Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish the heritability of glycaemic response to metformin using the genome-wide complex trait analysis (GCTA) method.
What does pain look like? Pain is felt, as every human being knows. But what about its visibility? Is it possible to depict pain? We can represent its visible expressions. We can also, to a certain extent, capture that which causes pain. But what about pain itself? This paper addresses the question of how to represent pain from a phenomenological perspective. Adopting the phenomenological analysis
NF-κB is constitutively activated in chronic lymphocytic leukemia (CLL); however, the implicated molecular mechanisms remain largely unknown. Thus, we performed targeted deep sequencing of 18 core complex genes within the NF-κB pathway in a discovery and validation CLL cohort totaling 315 cases. The most frequently mutated gene was NFKBIE (21/315 cases; 7%), which encodes IκBε, a negative regulato
Background and Aims: Saliva contamination has been suggested to be a major contributor to levels of cysteinyl leukotrienes in exhaled breath condensate (EBC). The aim of this study was to compare the levels of cysteinyl-leukotrienes (CysLT) and alpha-amylase activity in EBC to induced sputum and saliva collected from the same subjects (asthmatics and control). We thereby aimed to find out whether
Popular Abstract in Swedish Kalcium är ett livsviktigt ämne för både djur och växter. Kalcium behövs t.ex. för uppbyggnaden av skelettet, för att hjärtat skall slå och för att musklerna skall dras samman. I växter är kalcium en viktig beståndsdel i cellväggarna och behövs också vid bl.a. celldelning. Trots detta måste koncentrationen av fria kalciumjoner inne i cellen (i cellvätskan) hållas mycketThe calcium ion (Ca2+) is essential for all plant and animal life. One important function of Ca2+ is as a second messenger in the responses of the cell to environmental and hormonal signals as well as in some intrinsic developmental processes. The intracellular concentration of Ca2+ must be strictly regulated, since a high concentration of free cytosolic Ca2+ is toxic. All eukaryotic cells carry c
Studies have found that the cognitive model of worry developed by Dugas, Gagnon, Ladouceur and Freeston (1998) involving Intolerance of Uncertainly (IU), Cognitive Avoidance (CA), Positive Beliefs about Worry (PB), and Negative Problem Orientation (NPO) accounts for approximately 40-50% of the variance in worry frequency in adults. A recent trial of the treatment based on this model (Dugas, Brillo
Popular Abstract in Swedish Bakgrund När en kärlskada uppstår är det viktigt att blödningen snabbt kan stoppas. Detta åstadkomms genom att koagulationssystemet bildar en blodpropp vid skadestället. Von Willebrand faktorn (VWF) är ett stort protein som cirkulerar i blodet. Detta protein ingår, tillsammans med blodplättarna, i koagulationssystemets första fas. När ett kärl skadas binder VWF (som seVon Willebrand factor (VWF) is synthesized and secreted by endothelial cells into the plasma as a series of multimers. VWF induces the formation of platelet plugs at sites of vascular injury and high shear stress. Biological activity is dependent on multimeric size, which is regulated in plasma by the VWF-cleaving protease ADAMTS13. Severe ADAMTS13 deficiency is associated with thrombotic thromboc
This study evaluated the relative contribution of insulin-dependent mechanisms vs. mechanisms independent on dynamic insulin for glucose intolerance induced by high-fat diet. C57BL/6J mice underwent a frequently sampled intravenous glucose tolerance test (1 g/kg glucose) at 1 wk and 1, 3, and 10 mo after initiation of a high-fat diet (58% fat; control diet 11% fat) to measure glucose effectiveness
Agricultural overproduction has led the European Union to encourage long-term abandonment of agricultural land. To enhance the transition of agricultural land to natural grasslands or forests different management practices in relation to vegetation can be used. The aim of this study was to understand the interactions between plant and associated soil microbial communities during the succession of
Objectives. To evaluate the incidence of coronary events (CE) and case fatality in relation to common carotid intima-media thickness (IMT) and carotid plaque over a median follow up of 7 years. Subjects. A total of 5163 Swedish middle-aged men and women with no prior myocardial infarction and/or stroke. Methods and results. The associations amongst B-mode ultrasound determined common carotid IMT
We present new results for the inner valence levels of clusters of the three inert gases Ar, Kr and Xe based on photoelectron spectroscopy studies. The inner valence levels are compared to the localised core levels and to the delocalised outer valence levels. This comparison shows a gradual change from a relatively localised behaviour for Ar inner valence 3s, over the intermediate case of Kr inner
