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Prior to binding to antigenic peptide, the major histoconipatibility complex (MHC) heavy chain associates with an assembly complex of proteins that includes calreticulin, tapasin, and the transporter associated with antigen processing (TAP). Our data show that calreticulin can bind weakly to L-d without tapasin's assistance, and that deglycosylation of the alpha1 domain results in a primary loss o

The aim of the present study was to develop an understanding of how wheat plants can be used as a “green factory” by the modulation of genotype (G) and environmental (E) interactions to fine-tune the structure and increase the strength of gluten based materials. Two wheat genotypes (5 + 10 and 2 + 12) were grown under four nitrogen and two temperature regimes to obtain gluten of various characteri

Disperse dyes are well-known contact sensitizers not included in the majority of commercially available baseline series.

Online social media are a perfect text source for stance analysis. Stance in human communication is concerned with speaker attitudes, beliefs, feelings and opinions. Expressions of stance are associated with the speakers' view of what they are talking about and what is up for discussion and negotiation in the intersubjective exchange. Taking stance is thus crucial for the social construction of me

The recent years of development in mobile computing as powerful handheld computers and high-speed wireless networks creates opportunities for new user-groups in the mobile workforce to take advantage of mobile technologies. User-groups may be more or less geographical distributed and as a consequence more or less marooned when it comes to obtaining IT/IS support and this increases the complexity o

Late Katian (Late Ordovician) carbonate mudmounds in the TuresO Formation, Peary Land, North Greenland, succeed normal marine faunas dominated by brachiopods, bryozoans, cephalopod and gastropod molluscs, aulaceratid stromatoporoids, corals and receptaculitid algae, in the BOrglum River Formation, and are themselves succeeded by organic-rich, largely barren limestones. This peri-Laurentian success

We have studied the effects of cholesterol and steroid-based antibiotic fusidic acid (FA) on the behavior of lipid bilayers using a variety of experimental techniques together with atomic-scale molecular dynamics simulations. Capillary electrophoretic measurements showed that FA was incorporated into fluid 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine membranes. Differential scanning calorimetr

Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes ( polygenic component). We have now updated BOADICEA using additional family data from two UK population-based studies of brea

Abstract in UndeterminedThe author suggests a new model for interpretation of mystical experience, based on a fruitful combination of cognitive psychology and depth psychology. Offering a rather wide definition of mystical experience, the author then turns to two basic assumptions—a general systems approach and an organismic-holistic view of development. Hans Loewald's analysis of primary process

Popular Abstract in Swedish Vanligt viloelektrokardiogram (EKG) med 12 avledningar är ett av de mest använda redskapen för diagnostik av hjärtsjukdom. Tidigare forskning har visat att detta EKG ej är optimalt, men att nya EKG-metoder kan ge viktig tilläggsinformation. En metod som i flera tidigare studier visat sig innehålla diagnostisk potential är analys av de högfrekventa signalkomponenterna i The standard 12-lead electrocardiogram (ECG) is one of the most commonly used methods for diagnosing heart disease. Standard ECG is not always optimal, however, and new ECG methods can provide additional information. Analysis of high-frequency QRS components (HF-QRS) has been shown to increase the diagnostic performance of the ECG. Since the amplitudes of the HF-QRS are low compared with those vis

A molecular understanding of volatile anesthetic mechanisms of action will require structural descriptions of anesthetic–protein complexes. Porcine odorant binding protein is a 157 residue member of the lipocalin family that features a large β-barrel internal cavity (515 ± 30 Å3) lined predominantly by aromatic and aliphatic residues. Halothane binding to the β-barrel cavity was determined using f

Repair and reconstruction of major nerve trunks in the upper extremity is a very challenging surgical problem. Today, there is no surgical repair technique that can assure recovery of tactile discrimination in the hand of an adult patient following nerve repair. In contrast, young individuals usually attain a complete recovery of functional sensibility. The outcome from nerve repair depends mainly

Objectives: To determine if tumor vascularity as assessed by three-dimensional (3D) power Doppler ultrasound can be used to discriminate between benign and malignant ovarian tumors, if adding 3D power Doppler ultrasound to gray-scale imaging improves differentiation between benignity and malignancy, and if 3D power Doppler ultrasound adds more to gray-scale ultrasound than does two-dimensional (2D

Gel swelling experiments have been used to study the binding of ionic surfactants to a series of nonionic alkylacrylamide hydrogels of increasing hydrophobicity. The binding of hexadecyl trimethylammonium (C-16-TA(+)) to uncharged gels is sensitive to both the hydrophobicity of the gel and the counterion to the surfactant. There is a minimum hydrophobicity threshold below which binding of the surf

The number of local and regional-scale water management failures appears steadily to increase despite an apparently higher level of engineering solutions at hand. The objective of this paper is to examine the challenges the existing education system needs to meet in order to produce water engineers capable of responding to the complexity of contemporary and future water problems in relation to soc

Artikeln utgör en respons till ett föredrag om Derridas rättvisebegrepp, hållet av den isländske filosofen Björn Thorsteinson.