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Cystatin C functions in vitro and in vivo. Studies on target enzyme inhibition by cystatin C variants and cystatin C deficient mice.

Cystatin C variants with Arg8, Leu9 and/or Val10 replaced by Gly residues were produced by site-directed mutagenesis and E. coli expression. Their interactions with the target proteases, cathepsin B, L, H and S, were studied in vitro in order to provide basic structure-function information of use in the design of specific inhibitors for therapeutic use. Val10 was shown to be the most contributing

Barriärer och Styrmedel för kommunal klimatanpassning

I Västra Götalandsregionen är riskerna till följd av klimatförändringen allvarliga och därför är det avgörande med en ökad takt av kommunala klimatanpassningsåtgärder som kan möta klimatförändringarnas effekter. Detta aktualiserar en diskussion om styrmedel för att stimulera ökad klimatanpassning. Genom att intervjua 13 tjänstemän i 11 kommuner i regionen kartlägger denna studie förutsättningar fö

Strategy framework for sustainable industrial development in sub-Saharan Africa: Systems-evolutionary approach

The principal objectives of this research were: · to develop a conceptual framework on sustainability and sustainable development and · to propose a strategy framework for sustainable industrial development in Sub-Saharan Africa (SSA). The research was done based on systems evolutionary approach having the following methodological principles as a guide. · The dynamic complexity of environmental an

Numerical Investigation of Turbulent Fluid Flow and Heat Transfer in Complex Ducts

Th need for a reliable and reasonable accurate turbulence model without specific convergence problem for calculating duct flows in industrial applications has become more evident. In this study a general computational method has been developed for calculating turbulent quantities in any arbitrary three dimensional duct. Four different turbulence models for predicting the turbulent Reynolds stresse

The Alevi-Bektasi Legacy: Problems of Acquisition and Explanation

Mystics and amateur politicians in the margin of Turkish society. The specific case of marginalisation in the specific context of my choice provides a wealth of details to be accounted for. All details taken together are real life itself and can thus not be accounted for in a book. Enough can be said, however, about marginalisation in general in order for a meaningful discussion to take place. Bu