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Antibodies are key players of the immune system in higher vertebrates, which provide a defense against potentially lethal threats from the environment. Besides their importance in the immune defense, antibodies have a great potential as reagents in biological chemistry and diagnostics, and as therapeutic agents against both infectious diseases and cancer. Despite tremendous advances in all fields

Crossflow microfiltration is a technique to separate suspended particles (or cells or droplets) from liquids by use of a membrane that is permeable for the liquid but impermeable for the particles. The permeate flow drives particles to the membrane surface, where they may be deposited and form a fouling layer. To limit the growth of this fouling layer a flow is applied tangentially to the membrane

Glass sheets are often used in radon surveys to estimate retrospective radon concentrations, as radon progenies are embedded in the upper surface layer. The implanted activity is influenced by a variety of different environmental conditions. In this work, experimental methods based on etching to determine the depth distribution of recoil-implanted 210Po in glass from radon decay in air were develo

Perimetric threshold examination is the most important method for diagnosing and monitoring patients with glaucoma. Such examination, however, is time-consuming and often difficult for the elderly patients in whom glaucoma is prevalent. Shorter test strategies have been proposed, but unfortunately also with lower test quality. By using new computer-intense techniques for acquisition and processing

Magnetic relaxation dispersion measurements have been performed on aqueous protein solutions to study the dynamics of waters in the proton transport channel of bacteriorhodopsin and the self-association of the proteins BPTI, lysozyme and beta-lactoglobulin. The measurements have focused on the bulk relaxation rates, R1 and R2, of three water nuclei 1H, 2H and 17O that are coupled to the protein en

The number of software-based products is increasing, which is why the importance of an efficient software development process is also increasing, from a competitive advantage perspective. For years, software development organizations have been plagued by poor product quality and high development costs. Studies in software process improvement (SPI) have concerned themselves with improving the softw

The focus of this thesis is on the most widespread organizational change that the public sector has gone through during the 1990s: the introduction, implementation and continuous use of profit centers. There are three major reasons for studying profit centers. First, profit centers appear to have become a permanent element in the management of local government. Second, profit centers were used dif

This thesis describes different aspects of nanotechnology manufacturing with nanoimprint lithography (NIL), a relatively new nanofabrication tool capable of high resolution and high throughput. Surface structure creation with NIL is based on mechanical deformation of the patterning material. This is radically different from the two main established methods, ultra violet lithography (UVL) and elect

With the challenges Africa faces with respect to the predicted warming due to climate change, the continents role in the global carbon cycle has been increasingly recognized. Earth observing satellites have played a significant role in the study of vegetation, particularly in Africa where climate stations are sparse. Satellite data can provide the means to map plant primary production for monitori

The development of higher education in the Western countries involves ideas of internationalisation, included in curricular objectives. Policy-makers stipulate internationalisation ideologies, from a politico-economic perspective, where ideas about flows of various cultural elements are incorporated in visionary idealistic terms. Nevertheless teachers and students and others concerned with higher

This thesis describes chondroadherin, one of the leucine-rich repeat proteins in the extracellular matrix (ECM) of cartilage. Chondroadherin defines a subgroup of its own by not having an N-terminal extension, having a different cysteine pattern and by being devoid of carbohydrate substitutions. Here we show that chondroadherin also have a different exon-intron organization and chromosomal localiz

Structure activity relationship studies of synthetic flavone derivatives have been utilized to refine and evaluate a pharmacophore model of the benzodiazepine binding site of the GABAA receptors, originally developed by Zhang et al. (Drug Des. Discovery 1995, 12, 193-248). In addition to the previously proposed pharmacophore elements, two steric repulsive regions have been added to the model and t

Phase diagrams of mixed alkylglucoside surfactants, n-nonyl-b-D-glucopyranoside and n-decyl-b-D-glucopyranoside (C9G1 and C10G1) have been examined for the purpose of determining the microstructure surrounding a closed-loop miscibiliyt gap. There are large deuterium isotope effects on the phase diagram. NMR-self diffusion, cryoTEM and TRFQ experiments show the presence of long interconnect network

Friction Stir Welding (FSW) is a modern welding process that joins materials by frictional heat, generated by a rotating tool. Unlike other welding processes, the material never melts, which is beneficial for the weld properties. FSW is already widely adopted in several industries but the applications are limited to simple geometries like straight lines or circular welds, mostly in aluminium. The

The aims of the thesis were to investigate the prevalence of the upper extremity musculoskeletal disorders in female milkers in relation to other occupational groups; to clarify the relationship between disorders and work environment, psychosocial and life style factors; to compare in a prospective study, pain, ache and discomfort reported by a questionnaire with clinical symptoms and sign; to exa

The modified atmosphere packaging (MAP) of vegetables is used with the aim of prolonging the shelf-life of the packaged produce. The packaging material consists of a permeable film and as a result of the respiration of the produce and gas diffusion through the film, the O2 decreases and the CO2 increases inside the package. This thesis has focused on the MAP of broccoli and the effect of the packa

Individual-based determinations of the absorbed dose in radionuclide therapy largely rely on absolute measurement of the activity distribution and its redistribution over time. Scintillation-camera imaging is the most commonly employed measuring technique, applied in planar or SPECT mode, sometimes in combination with structural images from CT. In this thesis, methods for processing and analysis o

The main aim of the present investigation was to highlight middle childhood creativity, and the children’s perspective on creativity, in contrast to many, if not most, studies that investigate creativity from an adult perspective and a scholarly definition. This dissertation consists of two quasi-experimental studies, and one interview study. Study I investigated if, and how, state anxiety, brough

Human Beta-microseminoprotein is a 94 amino acid protein with 10 cysteins present in seminal plasma and on many mucosal surfaces in the body. The function of the protein is unknown. The purpose of this investigation was to study the distribution of Beta-microseminoprotein in the human body, especially in the stomach. The latter was studied under both normal and pathological conditions. A radioimmu

This thesis describes novel methods for the fabrication of nanometer-scale electronic devices, such as single-electron transistors and resonant tunneling diodes, from wire- and dot-shaped building blocks. The first part of the thesis describes the manipulation of metal nanoparticles and carbon nanotubes using an atomic force microscope. Single-electron transistors were realized by moving nanotubes