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Mismatch repair gene mutation spectrum in the Swedish Lynch syndrome population

Lynch syndrome caused by constitutional mismatch-repair defects is one of the most common hereditary cancer syndromes with a high risk for colorectal, endometrial, ovarian and urothelial cancer. Lynch syndrome is caused by mutations in the mismatch repair (MMR) genes i.e., MLH1, MSH2, MSH6 and PMS2. After 20 years of genetic counseling and genetic testing for Lynch syndrome, we have compiled the m

Four sustainability goals in a Swedish low-growth/degrowth context

Continual environmental degradation and an unfair distribution of environmental burdens and benefits are two great challenges for humanity. Economic growth is often taken for granted when planning for the future. However, it is often argued that maintaining economic growth conflicts with keeping human activities adjusted to ecological boundaries and finite resources, at least for the more-develope

Roman horticulture beyond the frontier : garden cultivation at Iron Age Uppåkra (Sweden)

Traditionally, the study of Roman cultural imports to Roman Iron Age societies in Scandinavia has been based on analysis of the artefactual record. The starting point has been artefacts held to be high-status objects deriving chiefly from funerary contexts and, to a lesser degree, from settlement sites. Although the existing evidence at Uppåkra, a high-status settlement site in Scania province, Sw

Comparison of a web-based food record tool and a food-frequency questionnaire and objective validation using the doubly labelled water technique in a Swedish middle-aged population

Two web-based dietary assessment tools have been developed for use in large-scale studies: the Riksmaten method (4-d food record) and MiniMeal-Q (food-frequency method). The aim of the present study was to examine the ability of these methods to capture energy intake against objectively measured total energy expenditure (TEE) with the doubly labelled water technique (TEEDLW), and to compare report

Component Importance for Multi-Commodity Networks: Application in the Swedish Railway

Preparedness and resilience planning for critical infrastructure networks requires evaluating the impact to the network when its components are disrupted. We extend the well-studied problem of component importance measures in single-commodity networks to multi-commodity networks by integrating a flow based multi-commodity optimization model with a multi-criteria decision analysis tool. A three-sta

Lifestyle and dietary determinants of serum apolipoprotein A1 and apolipoprotein B concentrations : Cross-sectional analyses within a Swedish Cohort of 24,984 individuals

Low serum apolipoprotein (Apo) A1 concentrations and high serum ApoB concentrations may be better markers of the risk of cardiovascular disease than high-density lipoprotein (HDL) and low-density lipoprotein (LDL). However, the associations between modifiable lifestyle factors and Apo concentrations have not been investigated in detail. Therefore, this study investigated the associations between A