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Precise spatial and temporal regulation of gene expression programs is a prerequisite for multicellular life. Since the discovery of DNA as the carrier of genetic information, a key question in biology has been how these hard coded instructions are read and regulated to maintain cellular and organismal homeostasis. Understanding the mechanisms and processes governing gene and genome regulation are
The complex genetics of cancer allows tumors to grow and spread undeterred by the control mechanisms of the cell. The importance of protein-coding genes in tumorigenesis is well established. Recently, microRNAs (miRNAs) have emerge as key regulator of development and cellular processes such as differentiation, cell growth and cell death; processes closely linked to cancer. The aim of this thesis w
The concept of actor capability outlines the basic features for the EU to be an international actor, separating it from nation-states and international organizations. This thesis applies this diagnostic concept to the case of EU-relations with the Democratic People’s Republic of Korea (DPRK). More specifically, it studies how the actor capability has changed by comparing the years 2001 and 2011 re
Underrättelsetjänster genererar generellt ett stort intresse för allmänheten. En bidragande orsak kan vara för att det är svårt att få en insyn i en sådan verksamhet. Insynen till verksamheten behöver förbättras, eftersom medborgare i en demokrati behöver förstå vad en underrättelsetjänst sysslar med, samt att underrättelsetjänsten ska kunna verka med högt förtroende. Denna intervjustudie undersök
The assembly of respiratory chain complexes in the mitochondrial inner membrane requires specific factors. Once assembled to form a mature functional complex, complex III (CIII) is a dimer consisting of two monomers, each with eleven subunits. To date, seven assembly factors for CIII are known, of which BCS1L incorporates the Rieske iron-sulfur protein (RISP) in the last stage of the assembly. The
This thesis is based on studies of the clinical use of induced hypothermia as an intervention to reduce mortality and neurological impairment after cardiac arrest. After the publication of two trials indicating benefit of induced hypothermia, we developed a registry to assess outcome, possible adverse events and conduct of induced hypothermia when this intervention was implemented in a clinical p
Contracts traded on international financial and commodity markets are associated with complex risk structures. In this dissertation we are concerned with two specific types of risks; market risks and credit risks. The first chapter investigates market risks in the context of the Nordic electricity market. The paper performs in- and out-of-sample backtesting of a VaR model based on GARCH volatili
The vantage point for this thesis is the passport as it was understood and used in the European Union from 1999 to 2001, as a requirement to cross the external borders of the EU and as a symbol of a united Europe free from a spectacular nationalism of the member states. According to nationalism, every nation should have its own state, and every state should be legitimized by a nation. If the mode
Lean has become a popular organization model during the late 21st century, and it is widely spread through healthcare with high expectations of improvement and reorganization. The implementation of a certain policy is in the literature seen as a crucial step in policy realization. To better understand Lean and its adaptation to healthcare, this study examines how Lean is being implemented into Swe
Factor H is the main fluid phase regulator of the alternative pathway of complement. Factor H acts as a co-factor for factor I-mediated C3b degradation, inhibits the formation of the C3bBb convertase and accelerates its decay. By discriminating between host and foreign cells, factor H inhibits complement-mediated injury to host cells. Factor H mutations have been associated with atypical hemolytic
The formation of the kingdom of Denmark is generally presented as a linear process linking ancient chiefs to the modern nation state of Denmark. This dissertation focuses on the small stories behind this great narrative of Denmark. The purpose is to show that there never was any formation process. Instead, encounters between people in the local landscapes and the Danish kingdom were both considera
This thesis consists of an introductory chapter and four research papers, summarized as follows. The overall purpose is to study various external effects of the transport system; effects that are not considered (or not fully considered) today. The first paper estimates the relationship between accident frequency and homogeneous and inhomogeneous traffic flows, which is useful for calculating the
The Grammar of The Hype digital information technology -IT- in retelling as myth its experienced reality and in scientific analysis or the IT-hype in the years prior to and at the turn of the millennium waiting for the next hype and the next, and“next”... This is the title of my thesis and it focuses rather on a particular “hype” than deals with the so-called information society as such. What is
The main purpose of this thesis is to examine the impact of social change on Chinese intergenerational relations in contemporary Singapore. Within only three decades, Singapore has turned into a wealthy and sophisticated metropolis with a highly educated labor force. The massive transformation, however, has been accompanied by the emergence of a deep and complex generation gap. Apart from the leap
