Filtyp
T2D is the most widespread endocrine disease. In conventional stimulus secretion coupling increased blood glucose is metabolized causing an increased intracellular level of ATP and closure of the KATP channels, and this, in turn, depolarizes the cell membrane leading to the opening of voltage-gated Ca2+ channels, the influx of Ca2+ and exocytosis of insulin granules. This model has become almost a
BACKGROUND: Umbilical cord blood gases are routinely used by midwives and obstetricians for quality assurance of birth management and in clinical research. They can form the basis for solving medicolegal issues in the identification of severe intrapartum hypoxia at birth. However, the scientific value of veno-arterial differences in cord blood pH, also known as ΔpH, is largely unknown. By traditio
BACKGROUND: Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with type 2 diabetes (T2D).METHODS: We conducted a systematic review and meta-analysis of longitudinal studies to identify potentially novel prognostic factors that could improve CVD risk prediction in T2D. Out of 9380 studies identified, 416 studies met inclusion criteria. Outco
Background: Unhealthy diets, the rise of non-communicable diseases, and the declining health of the planet are highly intertwined, where food production and consumption are major drivers of increases in greenhouse gas emissions, substantial land use, and adverse health such as cancer and mortality. To assess the potential co-benefits from shifting to more sustainable diets, we aimed to investigate
Aims/hypothesis: Galectin-1 modulates inflammation and angiogenesis, and cross-sectional studies indicate that galectin-1 may be a uniting factor between obesity, type 2 diabetes and kidney function. We examined whether circulating galectin-1 can predict incidence of chronic kidney disease (CKD) and type 2 diabetes in a middle-aged population, and if Mendelian randomisation (MR) can provide eviden
Land-use intensification of agricultural soils and increased occurrence and intensity of extreme weather events like drought periods are two of the main threats responsible for soil biodiversity declines. These changes in soil biodiversity can alter ecosystem functions performed especially by soil microbial communities that could further contribute to those threats. Microbial diversity is an essen
The conflict between seal conservation and fisheries in the Baltic Sea has becomeremarkably serious and threatens the existence of coastal fishing activities in theBaltic Sea. Seals cause significant catch losses, gear damage and various types ofhidden damages and losses. In particular, reports of damage caused by the grey seal,the largest and most common seal species in the Baltic Sea, have incre
Background: Most patients diagnosed with breast cancer present with a node-negative disease. Sentinel lymph node biopsy (SLNB) is routinely used for axillary staging, leaving patients with healthy axillary lymph nodes without therapeutic effects but at risk of morbidities from the intervention. Numerous studies have developed nodal status prediction models for noninvasive axillary staging using po
Energy metabolism dyshomeostasis is associated with multiple health problems. For example, abundant epidemiological data show that obesity and overweight increase the risk of cardiometabolic diseases and early mortality. Type 2 diabetes (T2D), characterized by chronically elevated blood glucose, is also associated with debilitating complications, high healthcare costs and mortality, with cardiovas
Compression ignited engines generally have higher efficiency than spark ignition engines. However, the most common combustion concept in compression ignited engines, conventional diesel combustion, struggles with high levels of particulate matter and NOx emissions. Therefore, new combustion strategies are used in compression ignited engines to reduce engine-out particulate matter and NOx emissions
Modern office buildings have high energy savings potential and potential for indoor climate improvements. During the nineties many office buildings with glass facades were built, in several cases with double skin glass facades. The advantages of buildings with double skin facades (compared with single skin glazed ones) are considered to be the reduced heating and cooling demand, the increased soun
Cerebrovascular pathology often co-exists with Alzheimer’s disease pathology and can contribute to Alzheimer’s disease-related clinical progression. However, the degree to which vascular burden contributes to Alzheimer’s disease pathological progression is still unclear. This study aimed to investigate interactions between vascular burden and amyloid-β pathology on both baseline tau tangle load an
Background AAUlco:hPollecaosencsounmfirpmtitohnatcaollnhteraibduintegsletvoelesxacreersesprmesoernbtiedditcyorarnedctmly:ortality in part through the development of alcohol-related medical conditions (AMCs, including alcoholic cardiomyopathy, hepatitis, cirrhosis, etc.). The current study aimed to clarify the extent to which risk for these outcomes differs as a function of socioeconomic position (
One of the most important challenges for modern society is how to feed the world in a sustainable manner. Agriculture is an essential part of food production, but at the same time it has many negative impacts on the environment, through for example pollution, nutrient leaching, and greenhouse gas emissions, and it is a big driver of biodiversity loss. Organic farming is a farming system that in ma
Background: Maximizing the efficiency to screen amyloid-positive individuals in asymptomatic and non-demented aged population using blood-based biomarkers is essential for future success of clinical trials in the early stage of Alzheimer’s disease (AD). In this study, we elucidate the utility of combination of plasma amyloid-β (Aβ)-related biomarkers and tau phosphorylated at threonine 217 (p-tau2
I Sverige är bevisvärderingen fri, vilket innebär att den inte är bunden av legala regler. Vid bevisvärderingen använder sig domaren av vad lagstiftaren benämner allmänna erfarenhetssatser, som möjliggör att bevisningen kan sättas i en kontext. Erfarenhetssatser utgör en generalisering beträffande hur omständigheter vanligtvis förhåller sig till varandra och baseras på allmän bildning och livserfa
Uppsatsen undersöker om Högsta domstolen (HD), genom att frångå lagstiftarens intentioner avseende vad som ska utgöra normalstraffet för mord, har överskridit sina befogenheter enligt regeringsformen (RF). Med normalstraff avses det straff domstolarna utgår ifrån när det bestämmer straffvärdet. I Sverige utgår all offentlig makt från folket, vilket betecknas som folksuveränitetsprincipen. Det vo
Syftet med regleringen av offentlig upphandling inom unionsrätten är att upprätthålla konkurrens och fri rörlighet på den inre marknaden inom Europeiska unionen. För att uppnå detta syfte finns ett grundläggande krav i upphandlingslagstiftningen på att offentliga kontrakt ska konkurrensutsättas genom annonsering. Trots det kan upphandlande myndigheter under vissa givna förutsättningar frångå kraveThe purpose of the regulation of public procurement in Community law is to maintain competition and free movement in the internal market within the European Union. To achieve this purpose it is a fundamental requirement of procurement legislation that public contracts must be subject to competition through prior publication of a contract notice. Nevertheless, contracting authorities are, under cer
