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BACKGROUND: Copy number (CN) variation (CNV) of the salivary amylase gene (AMY1) influences the ability to digest starch and may influence glucose homeostasis, obesity and gut microbiota composition. Hence, the aim was to examine the association of AMY1 CNV with fasting glucose, BMI, and gut microbiota composition considering habitual starch intake and to investigate the effect of AMY1 CNV on the

Background: Obesity is a major public health problem of our time as a risk factor for cardiometabolic disease and the available pharmacological tools needed to tackle the obesity pandemic are insufficient. Neurotensin (NTS) is a 13 amino acid peptide, which is derived from a larger precursor hormone called proneurotensin or Long Form NTS (LF NTS). NTS modulates neuro-transmitter release in the cen

Background: Patients diagnosed with oesophageal and gastric cancer face a poor prognosis and numerous challenges of symptom management, lifestyle adjustments and complex treatment regimens. The multifaceted care needs and rapid disease progression reinforce the need for proactive and coherent health care. According to the national cancer strategy, providing coherent health care and palliative supp

OBJECTIVE: Determination of lactate in fetal scalp blood (FBS) during labour has been recognised since the 1970s. The internationally accepted cutoff of >4.8 mmol/l indicating fetal acidosis is exclusive for the point-of-care device (POC) LactatePro™, which is no longer in production. The aim of this study was to establish a new cutoff for scalp lactate based on neonatal outcomes with the use of t

Background: Palliative care focuses on identifying, from a holistic perspective, the needs of those experiencing problems associated with life-threatening illnesses. As older people approach the end of their lives, they can experience a complex series of problems that health-care professionals must identify and document in their patients’ records. Documentation is thus important for ensuring high-

Background: Sepsis, the life-threatening organ dysfunction due to dysregulated host response to an infection, is a medical emergency. Early diagnosis and treatment are important factors to prevent mortality and morbidity. However, sepsis can be diffuse and difficult to interpret. Therefore, it is important to define models for early identification applicable in the Emergency Department (ED), in or

Range expansions can be shaped by sex differences in behaviours and other phenotypic traits affecting dispersal and reproduction. Here, we investigate sex differences in morphology, behaviour and genomic population differentiation along a climate-mediated range expansion in the common bluetail damselfly (Ischnura elegans) in northern Europe. We sampled 65 sites along a 583-km gradient spanning the

Disaster-induced and conflict-induced forced displacements areamong the biggest humanitarian and development challenges of the countriesaround the world in the 21st century. The increasing rate of the forced displacementputs significant pressure on the built environment which popularly includes thechallenges associated with delivering the essential goods and services, providingadequate and appropr

Background: Elevated cerebrospinal fluid (CSF) concentrations of total tau (T-tau) and phosphorylated tau at Thr181 (P-tau181) protein are typical of Alzheimer’s disease (AD). However, the T-tau assay measures only the mid-region of the protein, while tau in CSF is instead composed of a series of fragments. One fragment species in particular, N-224, shows increased levels in AD compared to control

Background: Most studies on synthetic computed tomography (sCT) generation for brain rely on in-house developed methods. They often focus on performance rather than clinical feasibility. Therefore, the aim of this work was to validate sCT images generated using a commercially available software, based on a convolutional neural network (CNN) algorithm, to enable MRI-only treatment planning for the

BACKGROUND: Opioids are still widely prescribed to long-term pain patients although they are no longer recommended for long-term treatments due to poor evidence for long-term efficacy, risks of serious side effects, and the possibility of inducing opioid hyperalgesia. In a Cochrane study from 2017, the authors identified an urgent need for more randomized controlled trials investigating the effici

BACKGROUND AND OBJECTIVES: Atrial fibrillation (AF) is associated with inflammation systemically and in the atrial tissue. Oxidized low-density lipoprotein (LDL) is increased in patients with AF and is suggested to be one of the molecules that drives inflammation. Autoantibodies against oxidized LDL and apolipoprotein B100, the protein component of LDL, are linked to atherosclerotic disease. Howev

The City of Stockholm can be characterized as evolving and changing while simultaneously, the region is being affected by climate change in accordance to RCP 4.5 and RCP 8.5. According to climate scenarios one of the effects of a changing climate in the region of Stockholm is an increase in precipitation and changes in precipitation patterns. This has prompted an interest in acquiring an in-depth

Sammanfattning Uppsatsens titel: Revisorns inställning till "den nya revisionsberättelsen" Seminariedatum: 5 juni 2015 Kurs: FEKH69, Kandidatuppsats, 15 poäng Författare: Andi Jojic, Edvina Latifi och Cornelia Merlöv Handledare: Alexander Paulsson Nyckelord: Förväntningsgap, “den nya revisionsberättelsen”, ISA 701, normer, tystnadsplikt, oberoende, självständighet, professionalitet, reAbstract Title: Auditors mindeset towards “the new audit report" Seminar date: June 5th, 2015 Course: FEKH69, Bachelor thesis, 15 points Authors: Andi Jojic, Edvina Latifi och Cornelia Merlöv Advisor: Alexander Paulsson Key words: Expectation gap, “the new auditor report”, ISA 701, norms, confidentiality, independence and autonomy, professionality, auditor profession, self-regulation. Purp

Rätten till nödvärn är en av de ansvarsfrihetsgrunder som rättfärdigar en annars brottsbelagd gärning. För att nödvärn ska föreligga måste nödvärnshandlingen inte vara uppenbart oförsvarlig samt och det måste föreligga en nödvärnssituation. I denna försvarlighetsbedömning granskas angreppets beskaffenhet, det angripnas betydelse och omständigheterna i övrigt. Andra faktorer som kan påverka bedömni

Sex chromosome evolution is a fascinating research topic because sex chromosomes provide a snapshot of evolution in many different lineages. Sex chromosomes often cease to recombine and therefore degenerate, and have also often been reshuffled during their evolution from autosomes. It has been discovered that within Sylvioidea passerine species half of chromosome 4a has translocated and fused with

Efterfrågan på nyproducerade bostäder är stor i Sverige och bygg- och fastighetssektorn står för en betydande del av samhällets miljöpåverkan. För att minska sektorns miljöpåverkan läggs idag allt större fokus vid att välja byggnadsmaterial med omsorg. Företaget BoKlok bygger bostäder industriellt och vill utreda miljöpåverkan från material som används i stor utsträckning, för att kunna ta större

This project will analyze the current situation for fiber routing. It will research how well planned excavations on the roads and their restorations are today. The project will also study how often road reinforcements and fiber routing are applied simultaneously and how experts perceive the situation. The project is carried out in the municipality of Svalöv who are currently building a fiber netwo