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IDDM is positively associated with HLA-DQA1*0301-DQB1*0302 (DQ8) and DQA1*0501-DQB1*0201 (DQ2) and negatively associated with DQA1*0102-DQB1*0602 (DQ6). The aim of the present study was to analyze the importance of several polymorphic residues and domains of DQalpha and DQbeta, in addition to residue 52 DQalpha and residue 57 DQbeta, with regard to susceptibility or resistance in new-onset 0- to 1

The metabolic syndrome is a clustering of several risk factors associated with diabetes and cardiovascular disease. Diabetes is a global problem with 90% of patients suffering from type 2 diabetes (T2D), which is attributable to various factors including genetic predispositions and lifestyle. In T2D, there is a reduction in β cell mass and function, and impaired glucose homeostasis. It is often as

Background: Excess body weight, physical activity, smoking, alcohol consumption and certain dietary factors are individually related to colorectal cancer (CRC) risk; however, little is known about their joint effects. The aim of this study was to develop a healthy lifestyle index (HLI) composed of five potentially modifiable lifestyle factors healthy weight, physical activity, non-smoking, limited

Diabetic patients suffer from macro- and microvascular complications causing increased morbidity and mortality. How hyperglycemia provokes vascular damage remains unclear, but glucose is believed to fuel a harmful low-grade chronic inflammation of the vessel wall. Previous work showed that glucose activates the transcription factor Nuclear Factor of Activated T cells (NFAT) in arteries ex vivo. NF

This thesis presents experimental results on the development and optimization of novel and highly compact sources of beams of fast ions, relativistic electrons and coherent x-rays, driven by intense laser-plasma interactions. The rapid development of high-power, short-pulse laser systems have made available peak powers reaching the petawatt regime and focused intensities reaching 10^21 W/cm2. Whe

Background: The n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid, which are present in fish, are protective against myocardial infarction. However, fish also contains methylmercury, which influences the risk of myocardial infarction, possibly by generating oxidative stress. Methylmercury is metabolized by conjugation to glutathione, which facilitates elimination. Glut

Programmatic vaccination and screening are the reasons for this thesis. The practice of public health incorporating medicine’s cognitive contents along with contributions from other fields of human activities is basically a moral enterprise. It is important that limitations from the whole continuum of these interventions are recognized to retain credibility. The changing demands resulting from the

Spondyloarthritis (SpA) is a group of interrelated inflammatory rheumatic diseases with the sub-diagnoses ankylosing spondylitis (AS), psoriatic arthritis (PsA), arthritis-associated inflammatory bowel disease (Aa-IBD), undifferentiated SpA (USpA), where stiffness and pain are key symptoms. Insidious onset back pain, morning stiffness, waking up at night, and improvement from exercise are common c

Glucagon secreted by pancreatic α-cells plays an important role in the regulation of blood glucose. In this thesis, different techniques such as electrophysiology, immunohistochemistry and hormone secretion assay were combined to explore the mechanisms by which glucagon secretion is regulated. Like pancreatic β-cells, which produce insulin, α-cells are electrically excitable and equipped with dif

L-type voltage-gated Ca2+ channels are expressed in the plasma membrane of muscles, neurons and endocrine cells where they serve as conductors of signals regulating cellular responses to changes in environment. Malfunctions of channels, as well as deregulations of their activity underlie numerous disorders and diseases commonly called channelopathies. In β-cells Ca2+ channels are central players f

Tolerance is crucial for maintaining immunological balance and avoid autoimmune diseases like type 1 diabetes and the inflammatory bowel disease, ulcerative colitis (UC). In Study I, we have investigated the regulatory role of a class of noncoding RNAs, the miRNAs, during thymocyte development of the where central tolerance is established. We used the non-obese diabetic mouse (NOD) which is spon

Climate change has become a societal issue that has gained increasing attention in recent years. The Intergovernmental Panel on Climate Change, IPCC, presented in year 2007 its Fourth Assessment Report, pointing out different scenarios about the future climate, including the anticipated sea level rises during this century. More recent climate research has shown that sea levels are most likely to r

Unga lagöverträdare särbehandlas idag straffrättsligt. De ska hållas utanför kriminalvården och istället företrädelsevis bli föremål för insatser inom socialtjänsten. Syftet bakom samarbetet mellan straffrätt och socialrätt är att unga individer är sårbara, påverkbara och med en bristande ansvarsförmåga. Denna samverkan kompliceras av att straff- och socialrätt är två rättsområden vars syftebeskriToday young law-offenders shall achieve special treatment in the penal system. They shall be kept out of the correctional services and instead primarily receive care from the social services. The purpose behind this cooperation between penal law and social law is that young individuals are vulnerable, impressionable and less accountable than adults. This collaboration is complicated due to the fac

I svensk rätt existerar sedan mycket länge en rätt för var och en att gripa personer som begår brott, om detta sker på bar gärning. I detta arbete undersöks ingående den bestämmelse i rättegångsbalken som reglerar detta förfarande. Vad gäller rekvisiten i bestämmelsen, framstår frågan om vad som ska anses vara på bar gärning som särskilt problematisk. Det är ett område där praxis också är tvetydig

En arbetsplats kan av olika skäl råka ut för en tillfällig nedgång i behovet av arbetskraft. Ett sätt att bemöta detta har traditionellt varit att tillgripa permitteringar. Permittering kan förekomma vid både tillsvidare- och visstidsanställda, men historiskt sett har det oftast rört sig om timanställda. Permitteringar förekommer i princip enbart på arbetarområdet. Med begreppet permittering menasA workplace can due to various reasons, experience a temporary decline in the demand for labor. One way to address this has traditionally been resorting to layoffs. Layoffs may occur in both permanent and fixed-term employments, but historically it has often been a matter of hourly employees. The term layoff means that an employer has the opportunity to temporary layoff employees, or due to some o

En grundläggande målsättning i svensk rätt är att barnets bästa ska sättas i främsta rummet och det ska alltid ske utifrån barnets individuella förhållan-den. Umgänge bedöms som utgångspunkt vara bra för barnet. Barn har rätt och behov av att träffa båda sina föräldrar och umgänge ska ske under trygga former. Genom att analysera och kombinera det som anses vara bra för barnet, barnets vilja, barne