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Background and aims: Obesity is on the rise globally, and is a leading risk factor for T2D. However, it is very heterogeneous, with varying degrees of T2D risk within the same levels of BMI. Better classification may lead to improve outcomes of current preventive and therapeutic strategies. Moreover, by elucidating the mechanisms uncoupling obesity from T2D risk, new possible therapeutic targets m
Fjärrvärme och fjärrkyla är ändamålsenliga system för distribution av värme och kyla i tätbebyggda områden. Dessa system är viktiga vid planeringen av framtida energieffektiva system på grund av deras höga potential för att integrera förnybara energikällor. Systemen spelar också en viktig roll i samhällets energiförsörjningssäkerhet, vilket gör dem till ett tvärvetenskapligt forskningsområde. Den District heating and cooling are efficient systems for distributing heat and cold in urban areas. They are a key solution for planning future urban energy-efficient systems due to their high potential for integrating renewable energy sources. The systems also play an important role in community resilience, which makes them a multidisciplinary research topic. The continuous development of these sys
In most cases, antiretroviral therapy (ART) results in undetectable plasma HIV viral load (VL). Still, up to 25% of ART recipients may have detectable low-level viremia (LLV) of different amplitude and persistence. This thesis explores the impact of LLV during ART on virologic and clinical outcomes. Paper I–III are retrospective analyses based on InfCare HIV, a national quality register for people
The normal-like molecular subtype of breast cancer has not been well characterized and is currently not included in the clinically approved PAM50 molecular subtype classification. Tumors classified as normallike display high expression of basal epithelial genes and low expression of luminal epithelial genes, but also high expression of genes expressed by non-epithelial cell types including adipocy
Background: Predicting future Alzheimer’s disease (AD)-related cognitive decline among individuals with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) is an important task for healthcare. Structural brain imaging as measured by magnetic resonance imaging (MRI) could potentially contribute when making such predictions. It is unclear if the predictive performance of MRI can be
Clay brick masonry façades are widely used because of their extended durability and aesthetic appeal. They also offer good protection against wind-driven rain (WDR), one of the most common moisture sources in Northern Europe. In clay brick masonry, WDR is associated with elevated water content and the possibility of water penetration, which may negatively impact the hygrothermal performance of bui
Cyanobakterier är urgamla prokaryoter, som finns i en mängd olika livsmiljöer över hela världen. Deras förmåga att utföra fotosyntes (det vill säga att använda solljus, vatten och koldioxid för att producera syre- och kolhydrater) gör dem till viktiga primära producenter, och tillsammans med andra växtplankton utgör de basen för akvatiska näringsvävar.Vid optimala tillväxtförhållandena kan populatCyanobacterial blooms are increasing in occurrence and frequency world-wide, mainly due to eutrophication and increased water temperatures. In freshwater, Microcystis is one of the most common bloom-forming genera, renowned for producing the toxin microcystin which is harmful to humans and other mammals. The ability of Microcystis strains to produce microcystins is largely due to the presence or a
Aims: Estimation of prognosis in pulmonary arterial hypertension (PAH) has been influenced by that various risk stratification models use different numbers of prognostic parameters, as well as the lack of a comprehensive and time-saving risk assessment calculator. We therefore evaluated the various European Society of Cardiology (ESC)-/European Respiratory Society (ERS)-based three-and four-strata
Purpose of the studyIn this paper, we discuss the unexploited possibilities of user-orientation to promote sustainable governance and management of value co-creation in innovation projects within welfare service ecosystem. The paper’s theoretical framework takes the outset in public service logic (PSL) and its user-oriented perspective. As such, we test the thesis that service-innovation seriously
BackgroundCongenic leptin receptor deficient rat generated by introgression of the Koletsky leptin receptor mutation into BioBreeding Diabetes Resistant rat (BBDR.lepr−/−) is a novel animal model combining obesity, systemic insulin resistance and diabetes. Systemic insulin resistance is associated with reduced myocardial glucose utilization, but its effect on myocardial external efficiency, i.e. t
This study critically evaluates David Harvey’s model of urban land rent and its centrality in his explanation of the material forces that underlie and limit urban land policies, strategies, planning decisions, and investment choices. Harvey emphasizes structural forces of capital in relating economic urbanization processes to uneven patterns of capitalist development, recurrent economic crises of
The purpose of this thesis is to add an astronomical component to the history and evolution of Earth by reconstructing the micrometeorite flux to Earth at different time intervals during the Phanerozoic Eon, using sediment-dispersed extraterrestrial spinel group minerals as a proxy. Chromite and chrome spinel are common refractory members of the spinel group, occurring in both extraterrestrial and
CUnT-SPLICING THOUGHT-FORMS — Promiscuous Play with Quantum Physics and Spirituality could perhaps best be described as an invocation of excited states. In more ways than one, this dissertation indulges in a weird threesome between quantum thinking, tantric practices, and feminist theory, with artistic practice at its core. It proposes the term “cunt-splicing”—a reference to ropework and the so-ca
Objective: To describe the short- and long-term outcomes of infants with early-onset fetal growth restriction (FGR) and umbilical artery absent or reversed end-diastolic flow (AREDF), delivered before 30 weeks' gestation and managed proactively. Methods: This was a retrospective cohort study of fetuses delivered for fetal indication before 30 completed weeks' gestation that had early-onset FGR (de
Importance: While clinical disease stages remained largely unchanged in the 2024 update of the Alzheimer disease (AD) criteria, tau-positron emission tomography (PET) was introduced as a core biomarker and its spatial extent was incorporated into the revised biological stages of the disease. It is important to consider both the clinical and the biological stages and understand their discrepancies.
Background: Cyclic Cushing's syndrome (cCS) features fluctuating cortisol secretion, often causing diagnostic errors or delays, and possibly poorer outcomes. We aimed to identify unpublished cCS cases to characterise clinical challenges and guide strategies for improving outcomes by characterising cycle patterns, peak frequency, and evaluating complications. Methods: This was a retrospective obser
Populärvetenskaplig sammanfattning: Under alla tider har planeten Jorden genomgått en naturlig klimat variation. Utöver denna naturliga variation i klimatet, så har människan, under det senaste århundradet, medverkat till en ökning av växthusgaser i atmosfären. Detta kan innebära att växthuseffekten intensifieras och Jorden bli utsatt för onaturliga temperaturökningar. Koldioxid (CO2), från bland In the context of climate change, it is important to understand how the terrestrial carbon cycle is interacting with the anthropogenic increase in atmospheric carbon dioxide (CO2) concentration. Boreal and subarctic regions in the northern hemisphere are great carbon pools, as well as they are subject to predicted warming. These facts place them in the absolute frontline of ecosystems that are to
Introduction.Kraft black liquor is a side-stream produced during the kraft pulping process containing lignin, hemicelluloses and cooking chemicals. The stream is usually evaporated and burned in the recovery boiler to recover the cooking chemicals and generate energy. The mill is, however, often/sometimes limited by recovery boiler capacity, and removing some of the lignin from kraft black liquor
