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The increased prevalence of individuals with Autism Spectrum Disorders (ASD) challenges society to evaluate the quality and efficacy of community based psycho-pedagogical programmes in order to achieve progress and to attain an acceptable level of quality of life for its citizens. The overarching aim of this thesis was to gain knowledge about staff’s pedagogical work and to provide a method for as

Aims: We tested whether autoantibodies to all three ZnT8RWQ variants, GAD65, insulinoma-associated protein 2 (IA-2), insulin and autoantibodies to islet cell cytoplasm (ICA) in combination with human leukocyte antigen (HLA) would improve the diagnostic sensitivity of childhood type 1 diabetes by detecting the children who otherwise would have been autoantibody-negative. Methods: A total of 686 pat

Background: Studies on leisure time physical activity as risk factor or protective factor for knee or hip osteoarthritis (OA) show divergent results. Longitudinal prospective studies are needed to clarify the association of physical activity with future OA. The aim was to explore in a prospective population-based cohort study the influence of leisure time physical activity on severe knee or hip OA

Background: Stroke is a major cause of mortality and morbidity across the world. Air pollution has become an acknowledged risk factor for stroke, especially for acute effects. There is less support for effects by chronic exposure due to the methodological challenges inherent in such studies. Such challenges can regard missing individual level data or residual confounding and can partly be overcome

BACKGROUND: Surveys are a common way to measure annoyance due to road traffic noise, but the method has some draw-backs. Survey context, question wording and answer alternatives could affect participation and answers and could have implications when comparing studies and/or performing pooled analyses. The aim of this study was to investigate the difference in annoyance reporting due to road traffi

OBJECTIVE: High concentrations of leukocytes in blood have been associated with diabetes mellitus. This prospective study aimed to explore whether total and differential leukocyte counts are associated with incidence of diabetes. A missense variant R262W in the SH2B3 (SH2B adaptor protein 3) gene, coding for a protein that negatively regulates hematopoietic cell proliferation, was also studied in

We previously demonstrated that the overall incretin effect and the β-cell responsiveness to glucagon-like peptide-1 (GLP1) are increased in insulin-resistant mice and may contribute to the upregulated β-cell function. Now we examined whether this could, first, be explained by increased islet GLP1 receptor (GLP1R) protein levels and, secondly, be leveraged by G-protein-coupled receptor 119 (GPR119

Aims: The general objective was to further elucidate thromboembolic disease in children and thereby help improve the care of these patients. More specific aims were as follows: to determine what children are affected by thrombosis; to discern any gender or age differences related to thrombosis; to identify prothrombotic risk factors; to ascertain whether autoantibodies against coagulation proteins

Lack of carbon has been assumed to be the most common limiting factor for bacterial growth in soil, although there are reports of limitation by nitrogen and phosphorus. I have studied nutrient limitation of bacterial growth in soil using a novel technique, where thymidine or leucine incorporation is used to detect changes in growth rates after adding nutrients. I have studied which nutrient(s) li

Over the last decade, a great variety of visionary ideas and beliefs have been brought forward, regarding the potentials of using computer games as a tool for learning and mediation in educational settings. This thesis aims at contributing to research in this field, by empirically exploring what happens when students play and reflect on their computer game play in science education. Three empirica

PURPOSE: Body mass index (BMI), waist-to-hip ratio (WHR), and tumor characteristics affect disease-free survival. Larger breast size may increase breast cancer risk, but its influence on disease-free survival is unclear. The purpose of this study was to elucidate whether breast size independently influenced disease-free survival in breast cancer patients. METHODS: Body measurements were obtain

Reconstructions of palaeomagnetic secular variation (PSV) in sediment cores can be compared to well-dated regional PSV master curves to infer deposition age. The existing PSV master curve for Fennoscandia, "Fennostack" (Snowball et al., 2007), is limited to the past 10 ka. In this study, we construct a deglacial (for the interval 14-11 ka) PSV master curve for Fennoscandia by including data from a