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Extraction of vitamin D, including its hydroxylated and esterified metabolites, from soft tissues such as the liver is challenging due to the lipophilic character of matrix and analytes that are expected in very low concentration levels. In this study, we aimed at the optimization of two-step extraction using solid–liquid extraction as the first step, followed by solid-phase extraction. Various so

BACKGROUND: Parkinson's disease (PD) is a chronic neurodegenerative disorder with limited knowledge about the normal function and effects of non-pharmacological therapies on the hypothalamic-pituitary-adrenal (HPA) axis. The aim of the study was to analyse the basal diurnal and total secretion of salivary cortisol in short- and long-term aspects of tactile massage (TM).DESIGN: Prospective, Control

Background: Diabetes in pregnancy is associated with increased risk of long-term metabolic disease in the offspring, potentially mediated by in utero epigenetic variation. Previously, we identified multiple differentially methylated single CpG sites in offspring of women with gestational diabetes mellitus (GDM), but whether stretches of differentially methylated regions (DMRs) can also be identifi

Informed by queer life practices, theories, and affinities, this documented artistic research project (doctoral thesis) draws from new materialist and post-humanist discourse in order to reconsider what role visual media play in the historical need to separate the human and the environmental. It asks, how do we challenge prevailing perceptions of film and photography as inexorably linked to ideas

Objective. To describe the change of pain reports over time in 3 cohorts derived from the general population: (1) no chronic pain (NCP, n = 1156); (2) chronic regional pain (CRP n = 502) and (3) chronic widespread pain (CWP; n = 242). To identify risk factors that predict the development or persistence of chronic widespread pain. Methods. A 3-year followup from 1995 to 1998 with postal questionnai

BACKGROUND: People of Sub Saharan Africa (SSA) and South Asians(SA) ethnic minorities living in Europe have higher risk of stroke than native Europeans(EU). Study objective is to provide an assessment of gender specific absolute differences in office systolic(SBP) and diastolic(DBP) blood pressure(BP) levels between SSA, SA, and EU.METHODS AND FINDINGS: We performed a systematic review and meta-an

The aim of the work presented in this thesis was to improve the management ofinfections in immunocompromised patients by studying aspects of diagnostics,epidemiology and nosocomial transmission. Infection and rejection are commoncomplications in lung-transplant patients, and early diagnosis and treatment areimportant for a positive outcome. In a study of lung-transplant patients it wasfound that hThe aim of the work presented in this thesis was to improve the management of infections in immunocompromised patients by studying aspects of diagnostics, epidemiology and nosocomial transmission. Infection and rejection are common complications in lung-transplant patients, and early diagnosis and treatment are important for a positive outcome. In a study of lung-transplant patients it was found t

Behovet av förnybar energi är stort och förväntas öka i framtiden. I Sverige står vattenkraft för en betydande andel av elproduktionen, där anläggningarna ofta innebär fysiska hinder för vandringsberoende fiskarter. För att bibehålla elproduktionen och samtidigt säkerställa god konnektivitet i vattendragen krävs väl fungerande migrationslösningar förbi kraftverken, både för uppströmsvandrande och

I takt med att komplexiteten inom vissa rättsområden ökat, har även behovet vuxit fram av en domstolsorganisation med fördjupad kunskap och kompetens att handlägga tvister inom dessa områden. För att uppnå sådan specialisering har rättskipningen i Sverige delats upp mellan olika särskilda och speciella domstolar, där varje domstolsslag har exklusiv behörighet att pröva mål som faller inom dess res

Brukaranalyser, eller analyser med syfte att identifiera och framlägga bevis för vem som använt viss enhet eller något som anses anslutet till viss enhet under viss tid, är numera vanligt förekommande i brottmålsprocessen. Alltjämt föreligger dock utrymme för diskussion kring användningen av bevismedlet. Det övergripande syftet med uppsatsen är därav att analysera och problematisera hur brukaranal

År 1977 infördes nämndemän i hovrätten vid brottmålsprövningar för att öka allmänhetens insyn och förtroende för rättsskipningen. Generella argument om att nämndemän även kunde bidra med inflytande i rättsskipningen genom kunskap om till exempel person- och ortkännedom fördes också fram i den statliga utredningen som låg bakom införandet. Trots detta begränsades nämndemännens inflytande från börja

Barn och unga som enlig LVU är placerade på särskilda ungdomshem befin-ner sig i en särskilt utsatt situation. Utöver de särskilda befogenheter som ut-tryckligen regleras i LVU och som inskränker barnens grundläggande rättig-heter, används i praktiken även åtgärden fasthållning. Denna åtgärd är inte reglerad i LVU som särskild befogenhet men används ofta i samband med eller i stället för avskiljniChildren and young people who, according to the Care of Young Persons (Special Provisions) Act (the Act), are placed in special residential homes are in a particularly vulnerable state. In addition to the special authorities express-ly regulated by law, which restrict the fundamental rights of children, the measure of physical restraint is also used in practice. This measure is not regulated in th

INTRODUCTION: Tourette syndrome (TS) and chronic motor or vocal tic disorder (CTD) are neurodevelopmental disorders associated with functional impairment and reduced quality of life. Behavioral therapy (BT) is an effective treatment, but lack of experienced practitioners makes it hard for patients to receive appropriate help. One approach to bridge the gap between demand and availability is to off

Background: Catheter-associated urinary tract infections and bladder distension are common and preventable adverse events. This study presents a process evaluation of a bladder bundle, designed to change healthcare professionals’ way of thinking and acting to prevent these adverse events, using theories of organizational culture, leadership, and an integrated knowledge translation approach. Aim: T

Background: Physical activity (PA) in childhood is critical for establishing a healthy lifestyle across the lifespan, particularly to treat and prevent obesity. This study aimed to explore PA and sedentary behaviour (SED) in 6–12-year-old children with obesity and their parents, and possible associations in these behaviours between children and parents. Methods: Children referred to outpatient pae

OBJECTIVES: The Sepsis-3 definition states the clinical criteria for sepsis but lacks clear definitions of the underlying infection. To address the lack of applicable definitions of infection for sepsis research, we propose new criteria, termed the Linder-Mellhammar criteria of infection (LMCI). The aim of this study was to validate these new infection criteria.DESIGN: A multicenter cohort study o

Background: The increased risk of colorectal cancer (CRC) associated with family history of both colorectal in situ or invasive carcinomas (Stage 0 to IV) and colorectal polyps is attributed solely to family history of CRC, resulting in an underestimation of the actual risk. We aimed to assess the association between overall and early-onset CRC (EOCRC) risk and family history of both colorectal ca

IntroductionThis multicenter, prospective observational study aimed to evaluate the performance of the StatStrip® Lactate 2 (Nova Biomedical, Waltham, US) point-of-care device for fetal blood lactate measurement and to determine the corresponding lactate value equivalent to the established intervention cutoff used with the outgoing StatStrip® Lactate device.Material and MethodsThe study was conducIntroduction: This multicenter, prospective observational study aimed to evaluate the performance of the StatStrip® Lactate 2 (Nova Biomedical, Waltham, US) point-of-care device for fetal blood lactate measurement and to determine the corresponding lactate value equivalent to the established intervention cutoff used with the outgoing StatStrip® Lactate device. Material and Methods: The study was c