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Fat-soluble vitamin D is an essential bioactive compound important for human health. Insufficient vitamin D levels can result not only in bone disease but also in other disorders, such as cancer, metabolic disorders, and diseases related to poor immune function. The current methods commonly used for vitamin D analysis are often applied to determine the levels of the most abundant metabolite in pla
Biopharmaceuticals are complex biological molecules that require careful storage and handling to ensure medication integrity. In this study, a work system analysis of real-world protein drug (PD) handling was performed with the following goals: identify main barriers and facilitators for successful adherence to accepted recommendations in PD handling, analyse differences in two organizations, and
INTRODUCTION: With the implementation of early reperfusion therapy, the number of complications in patients with acute coronary syndrome (ACS) has diminished significantly. However, ACS patients are still routinely admitted to units with high-level monitoring such as the coronary or intensive care unit (CCU/ICU). The cost of these admissions is high and there is often a shortage of beds. The aim o
Background: The molecular pathways linking short and long sleep duration with incident diabetes mellitus (iDM) and incident coronary heart disease (iCHD) are not known. We aimed to identify circulating protein patterns associated with sleep duration and test their impact on incident cardiometabolic disease. Methods: We assessed sleep duration and measured 78 plasma proteins among 3336 participants
Denna uppsats belyser problematiken med överprövningar som föranleder upphandlande myndigheter att frångå det obligatoriska annonseringskravet genom att direktupphandla samhällsåtaganden på grund av synnerlig brådska. Att en upphandlande myndighet blivit tvungen att direktupphandla ett samhällsåtagande, i syfte att utföra en obligatorisk skyldighet, för att det uppstått brådska på grund av överpröThis thesis highlights the problem of review procedures that lead contracting authorities to waive the mandatory publication of a contract notice by directly procuring public commitments due to extreme urgency. The fact that a contracting authority has been forced to directly procure a public commitment, in order to perform a mandatory duty, in the event of urgency due to a review procedure will n
Solidariskt ansvar är huvudregeln när flera skadevållare gör sig skyldiga till en och samma skada. Solidariskt skadeståndsansvar innebär att skadelidande kan kräva en av skadevållarna på hela skadeståndsbeloppet som om skadevållaren skulle varit ensam ansvarig. Det krävs att de allmänna förutsättningarna för skadeståndsskyldighet är uppfyllda för var och en av skadevållarna. Den som har blivit krä
Bröstcancer är den vanligaste cancerformen hos kvinnor i Sverige och står ensam för 30 % av cancerdiagnoserna. Detta innebär att varje dag får 20 kvinnor beskedet att de har drabbats av bröstcancer. Idag får ungefär 50 % av alla cancerpatienter strålbehandling och på strålbehandlingsavdelningen vid Skånes universitetssjukhus (SUS) behandlas flertalet bröstcancerpatienter dagligen. Vanligast är aBackground and purpose: Post-operative adjuvant radiotherapy of left-sided breast cancer patients is associated with cardiac and pulmonary complication. By utilizing different respiratory gating techniques the absorbed dose to the heart and lung can decrease. The purpose of this study was to evaluate and compare enhanced inspiration gating (EIG) and deep inspiration breath hold (DIBH). The use of
Digitala Självbetjäningslösningar – Den utmanande tjänsten En studie av bankers övergång till digitala självbetjäningslösningar Josefine Andreasson Charlotte Mikander 2014-09-11 Handledare: Kandidatuppsats Catharina Norén 2014 Abstract Why: Bachelor thesis, Service Management, Lunds University, Campus Helsingborg, Spring 2014 Authors: Josefine Andreasson & Charlotte Mikander Title: Di
Glaciärer har visat sig vara känsliga för klimatologiska förändringar i sitt närområde och deras känslighet sträcker sig över flera olika tidsskalor. Glaciärerna har därför kommit att användas som indikatorer på både pågående och förhistoriska klimatförändringar. För att glaciärerna ska kunna spegla klimatet så krävs emellertid tillförlitliga mätmetoder av glaciärernas massa. I avsikt att återge gGlaciers integrate variations in climate over several different time scales and are thus used as indicators of both present and past climate change. It is however of importance to be able to correctly measure changes in the glaciers mass over time (the glaciers mass-balance), if one wishes to use the glaciers as climate indicators. The mass-balance of a glacier is a direct result of the glaciers a
Under an action research paradigm, this thesis project explores the business potential of an environmental strategy and assesses the formulation of such a strategy implemented by an automotive original equipment manufacturer. Because of the heterogeneous nature of a company’s approach to environmental issues due to inter alia managerial conducts and company culture, this article provides an in-dep
All införskaffning av varor, tjänster och byggentreprenader som görs inom den offentliga sektorn ska som huvudregel föregås av en offentlig upphandling. Offentlig upphandling kan definieras som en urvalsprocess med vissa moment som till sist leder till att den upphandlande myndigheten tecknar avtal med en vinnande leverantör. Det upphandlingsrättsliga regelverket inom EU består främst av två direkAll procurement of goods, services and works made in the public sector shall in principle be preceded by public procurement. Public procurement can be defined as a selection process with some elements that finally leads to that the contracting authority signs a contract with the winning supplier. The procurement legal framework in the EU mainly consists of two directives; directive 2004/18/EC and
En fjärdedel av de homosexuella, bisexuella och transpersoner som deltagit i en stor undersökning år 2013 hade blivit utsatta för hot och våld. Personerna utsätts bland annat för att de inte tillhör normen. Enligt straffskärpningsregeln i 29 kap. 2 § 7 p. BrB är det en försvårande omständighet vid bedömningen av straffvärdet om ett motiv för en brottslig gärning varit att kränka en person, folkg
Background: Endocrine disrupting chemicals (EDCs) can cross the placenta and thereby expose the fetus, which may lead to developmental consequences. It is still unclear which chemicals are of concern regarding neurodevelopment and specifically behaviour, when being exposed to a mixture. Objective: The objective is to determine associations between prenatal exposure to EDCs and behavioural difficul
Background: Immune checkpoint inhibitors are now a part of the treatment arsenal for triple-negative breast cancer (TNBC) but refinement of PD-L1 as a prognostic and predictive biomarker is a clinical priority. We aimed to evaluate the relevance of novel PD-L1 immunohistochemical (IHC) thresholds in TNBC with regard to PD-L1 gene expression, prognostic value, tumor infiltrating lymphocytes (TILs),
Introduction: Elevated red cell distribution width (RDW) has been associated with a range of health outcomes. This study aims to examine prognostic and etiological roles of RDW levels, both phenotypic and genetic predisposition, in predicting cardiovascular outcomes, diabetes, chronic kidney disease (CKD) and mortality. Methods: We studied 27,141 middle-aged adults from the Malmö Diet and Cancer s
1. The mechanisms driving nonrandom assembly patterns in plant communities have long been of interest in ecological research. Competing ecological theories predict that coexisting species may either be more functionally dissimilar than expected by chance (with functional divergence' mainly reflecting niche differentiation) or be functionally more similar than expected (with functional convergence'
Background: As the survival rate of preterm infants continues to rise worldwide, more infants are at risk of developing sight-threatening retinopathy of prematurity (ROP). Destructive retinal laser treatment and intravitreal injections of anti-vascular endothelial growth factor (VEGF), factor, which have potential systemic side effects, are necessary to prevent blindness in severe cases of ROP. Of
Objective To date, the major pathways contributing to cardiovascular disease among night shift workers remain poorly understood. MicroRNAs (miRNAs) have been identified as novel regulators of cardiovascular risk factors and are estimated to control more than 30 candidate miRNAs among night shift workers.Materials and Methods RNA was extracted from plasma samples of 110 night and 90day shift worker
