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Inom nuvarande könsnormer så ses kön främst som ett uttryck av biologiska könsgrupper som är binära och olika, men kompletterande. En performativ syn på kön analyserar i stället kön som något som uppstår under sociala interaktioner genom konstant repetition av handlingar som sker inom förhärskande könsdiskurser. Dessa hegemoniska könsdiskurser konstruerar kön som fundamentalt heterosexuellt. DärmeCurrent gender norms predominantly construct gender as an expression of binary sex categories that are different but complementary. A performative view of gender instead analyses gender as an emergent feature of social interactions that is created by the constant repetition of acts in relation to discourses of gender. Within these hegemonic discourses, gender is constructed as fundamentally hetero

Background: Markers of downstream events are a key component of clinical trials of disease-modifying therapies for Alzheimer’s disease (AD). Morphometric metrics like cortical thickness are established measures of atrophy but are not sensitive enough to detect Aβ-related changes that occur before overt atrophy become visible. We aimed to investigate to what extent diffusion MRI can provide sensiti

Background and ObjectivesIdentifying a clinically meaningful change in cognitive test score is essential when using cognition as an outcome in clinical trials. This is especially relevant because clinical trials increasingly feature novel composites of cognitive tests. Our primary objective was to establish minimal clinically important differences (MCIDs) for commonly used cognitive tests, using a

Aims/hypothesis: Monogenic forms of diabetes (MODY, neonatal diabetes mellitus and syndromic forms) are rare, and affected individuals may be misclassified and treated suboptimally. The prevalence of type 1 diabetes is high in Finnish children but systematic screening for monogenic diabetes has not been conducted. We assessed the prevalence and clinical manifestations of monogenic diabetes in chil

Background: The 2019 European Working Group on Sarcopenia in Older People (EWGSOP2) and the Sarcopenia Definitions and Outcomes Consortium (SDOC) have recently proposed sarcopenia definitions. However, comparisons of the performance of these approaches in terms of thresholds employed, concordance in individuals and prediction of important health-related outcomes such as death are limited. We addre

Background: Accumulation of saturated fatty acids (SFAs) in the liver is known to induce hepatic steatosis and inflammation causing non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Although SFAs have been shown to affect the epigenome in whole blood, pancreatic islets, and adipose tissue in humans, and genome-wide DNA methylation studies have linked epigenetic ch

BACKGROUND AND OBJECTIVES: Injured pericytes in the neurovascular unit release platelet-derived growth factor β (PDGFRβ) into the cerebrospinal fluid (CSF). However, it is not clear how pericyte injury contributes to Alzheimer's disease (AD)-related changes and blood brain barrier (BBB) damage. We aimed to test if CSF PDGFRβ was associated with different AD- and age-associated pathological changes

Objective: The mechanisms and metabolomic profile underlying early vascular ageing have not been explored in the general population. We aimed to investigate the plasma metabolomic profile in aortic stiffness (vascular ageing) and associated risk of incident cardiovascular disease and mortality in the general population.Design and method: We analysed 108 metabolites in plasma of 5172 individuals fr

Ventricular-arterial coupling (VAC) has independent diagnostic and prognostic value for cardiovascular (CV) risk stratification, but studies on its association with anthropometric and CV factors are sparse in young individuals without overt CV disease. We aim to provide descriptive data regarding VAC and its associations with CV risk factors in young adults without overt CV disease. For 631 (mean

Background AU Self-reported: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly adherence to the Mediterranean diet has been: modestly inversely associated with incidence of type 2 diabetes (T2D) in cohort studies. There is uncertainty about the validity and magnitude of this association due to subjective reporting of diet. The association has not been evaluated using an objectively measured

Aims/hypothesis: Low birthweight is a risk factor for type 2 diabetes but it is unknown whether low birthweight is associated with distinct clinical characteristics at disease onset. We examined whether a lower or higher birthweight in type 2 diabetes is associated with clinically relevant characteristics at disease onset. Methods: Midwife records were traced for 6866 individuals with type 2 diabe

BACKGROUND: Genetic screening for pathogenic variants (PVs) in cancer predisposition genes can affect treatment strategies, risk prediction and preventive measures for patients and families. For decades, hereditary breast and ovarian cancer (HBOC) has been attributed to PVs in the genes BRCA1 and BRCA2, and more recently other rare alleles have been firmly established as associated with a high or

Skogar har en positiv inverkan på halten av växthusgaser i atmosfären eftersom de binder koldioxid via fotsyntesen och lagrar kol i marken. Dessutom utgör många skogar en betydande sänka för växthusgasen metan. Upptaget av metan sker i väl syresatta marker genom oxidation utförd av metanotrofa bakterier. Däremot sker en nettoproduktion av metan i syrefattiga skogsmarker när mikroorganismer, s.k. aPopular Abstract in English Forests have a positive impact on the level of greenhouse gases in the atmosphere because they absorb carbon dioxide through photosynthesis and store carbon in the soil. Moreover, many forests function as a sink for the greenhouse gas methane (CH4). The uptake of CH4 takes place in well-aerated soils through oxidation by methanotrophic bacteria. However, there is a net

In addition to being a key criterion of the sustainable development proviso, for business, the integration of social- and ecological considerations into decision-making is of growing importance for minimising future environmentally-related risk and associated economic costs, as well as gaining a share in growing markets favouring products and companies focusing upon social responsibility and ecolo

Syftet med detta Forska och Väx-projekt har varit att öka konkurrenskraften för InView AB genom att tillsammans med forskare bedriva användarcentrerad utveckling av tjänster på ippi-systemet i fyra olika kommuner med lokala behov. Projektet har genomförts med mål att ta fram ett tjänsteutbud som svarar upp till kommunens behov av en ny plattform för hållbar och kvalitetssäkrad kommunikation i äldr

Signs of Flesh: Institution and Body in Accounts of Paranoia (Notes on Schreber and Fabian) As the call for paper to this conference aptly states, phenomenology holds that "[c]onsciousness [is] dependent on a body and a world, which bestow it with existence and meaning." My take on this phenomenologist axiom would be to suggest a complementary thesis, something like: "The world (understood as the

The working life of today is characterized by a changing environment with heavier workload, lack of control, temporary work contracts and decreased workplace support. In recent years there has been a growing interest in studying the impact of insecure employment and several studies show that organizational changes and downsizing have negative consequences for the employees. Some authors argue that

(1) Background: Obstructive sleep apnea (OSA) is common in patients with coronary artery disease (CAD), in which a rupture of atherosclerotic plaques and oxidative stress play a role in the initiation and progression of the disorder. Circulating levels of myeloperoxidase (MPO), as an oxidative stress marker, as well as matrix metalloproteinase-9 (MMP-9), as a destabilizer of plaques, are known to