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INTRODUCTION: The immune microenvironment plays a crucial role in the progression of colorectal cancer (CRC), but its variation across primary tumors and metastatic sites remains incompletely understood. In this study, we compared the composition and prognostic significance of the immune microenvironment in lung metastases, paired primary tumors, and liver metastases from a retrospective cohort of

Background: C3 is highly expressed in human and rodent pancreatic islets, which secrete insulin to regulate blood glucose homeostasis. We have previously shown that cytosolic C3 protects pancreatic beta-cells from stress, by allowing cytoprotective autophagy, and that the same intracellular pool of C3 also protects beta-cells from cytokine-induced apoptosis. Methods: We now generated a beta-cell s

BACKGROUND: Neurointensive care is moving toward more automated patient management. This study aimed to evaluate a novel external ventricular drainage (EVD) system, the VGuard® system, as a tool for intracranial pressure (ICP) monitoring and automating ventricular drainage of cerebrospinal fluid (CSF), focusing on its safety and potential to reduce complications associated with manual EVD manageme

OBJECTIVE: Diabetes significantly increases the risk for atherosclerotic complications, including coronary artery disease (CAD). Previous studies have suggested that adult-onset diabetes can be classified into five different clinical subtypes, including moderate obesity-related diabetes (MOD). The aim of this study was to investigate the genetic associations between the five diabetes subtypes and

This study examined how self- and teacher-rated executive functioning (EF), measured with the Behavior Rating Inventory of Executive Function – Second Edition, differed between adolescents with and without self-reported neurodevelopmental disorders (NDDs; e.g., autism), across levels of internalizing symptoms, and how EF, NDDs, and internalizing symptoms related to academic achievement. Analyses i

Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors, including abdominal obesity, insulin resistance, dyslipidemia, and hypertension. Its association with venous thromboembolism (VTE) has been inconsistently reported. We investigated the association between MetS and VTE, and the influence of sex and abdominal obesity. We included 12,788 middle-aged and older adults from the re-ex

Background: Insulin resistance and impaired insulin secretion are hallmarks of type 2 diabetes (T2D) and may influence risks of complications including dementia. We investigated dementia risk across T2D subgroups defined by beta-cell function and insulin sensitivity. Methods: We used Homeostasis Model Assessment-2 indices of beta-cell function (HOMA2-B) and insulin sensitivity (HOMA2-S) to classif

Background: Postoperative lymph node irradiation can affect shoulder morbidity in breast cancer patients, yet widely accepted dose-volume constraints for the shoulder joint are lacking. The SENOMAC trial randomized patients with breast cancer and 1–2 sentinel lymph node (SLN) macrometastases to axillary lymph node dissection (ALND) or SLN biopsy only. We aimed to analyze the association between th

BackgroundAlzheimer’s disease (AD) is the most common cause of dementia and a growing healthcare challenge. Amyloid-targeting therapies (ATT) may slow progression, but implementation is limited by logistical and economic barriers. As primary care is the first contact for most patients with cognitive concerns, quantifying treatment eligibility in this setting is essential. The purpose of this study

Background: This is one of the few European studies of self-management and self-monitoring during the initial two weeks following discharge after open cardiac surgery. Typical outcomes are mortality, morbidity, surgical complications and additional medical treatment. Equally important for enabling person-centred care are the patients’ perspective and main concerns. The aim was to explore feasibili

BACKGROUND/AIM: Determining the causation of an injury in living individuals is a key task for forensic pathologists. However, little is known about sex-based differences in injury characteristics. The study aims to examine sex-based differences in single stab injuries to the trunk among assault survivors, to potentially identify injury patterns that could aid forensic assessment and help in the m

Background: First-line managers in healthcare operate in increasingly complex environments marked by high demands, rapid change, and limited resources. These conditions impact their health, leadership capacity, and the sustainability of their roles. While previous research has addressed various aspects of leadership in healthcare, there is a lack of studies focusing specifically on how first-line

The evacuation of hospitals in the event of fires and similar emergencies can be a difficult endeavor. Patients usually require assistance, with a considerable number of them being unable to evacuate by themselves due to medical conditions or due to the treatment they are receiving. Assistance is to be provided by the healthcare staff in the affected ward, which means that their level of preparedn

Background: Optimal treatment and support in family planning for women with type 1 diabetes (T1D) and follow-up during pregnancy are important, however, there is limited knowledge from the women’s perspective on their considerations of family planning, pregnancy, and motherhood. Objectives: To explore expectations and experiences of family planning, pregnancy, and motherhood among women with T1D.

Examensarbetets titel: Borta Bra men Hemma Bäst?: En kvalitativ flerfallsstudie om hur svenska startups väljer produktionsplats Seminariedatum: 3 juni, 2022 Ämne/kurs: FEKH99, Examensarbete i Entreprenörskap och Innovation, 15 högskolepoäng Författare: Elias Alhar, Karl-Oscar Giertz och Måns Wirfelt Handledare: Joakim Winborg Nyckelord: Entreprenöriellt beslutsfattande; Supply chain management; Lä

Denna uppsats har som syfte att förstå sakrättslig identitet utifrån situationen att en sak blir en ny sak. Utifrån syftet har uppsatsen formulerat två frågeställningar; När blir en sak en ny sak? och Hur ska sakrättslig identitet förstås? Inom sakrätten finns det en tydlig situation där dessa överväganden kommer i ljuset, nämligen legotillverkning. Legotillverkning behandlar situationen av att

Uppsatsen behandlar likhetsprincipen och generalklausulerna i svensk aktiebolagsrätt. Reglerna utgör en del av det så kallade minoritetsskyddet. Även om bestämmelserna är gamla, är tillämpningen och förhållandet mellan likhetsprincipen och generalklausulerna något som fortfarande debatteras. Syftet med uppsatsen är att utröna hur tillämpningen av reglerna ska förstås och hur de förhåller sig till

Resning är ett av de extraordinära rättsmedlen som finns i svensk processrätt och är att se som ett undantagsfall till huvudregeln om att domstolars avgörande, som vunnit laga kraft, förblir orubbade. När ett mål beviljas resning blir det föremål för en ny domstolsprövning och det kan ske antingen till fördel eller nackdel för den tilltalade. Uppsatsen redogör för de motiv som ligger bakom det mod

30 juni 2022 trädde en omfattande ändring av lag (1982:80) om anställ-ningsskydd i kraft. Ändringarna syftade dels till att göra det lättare för ar-betstagare att komma in samt få en trygg anställning på arbetsmarknaden, dels att göra det enklare och mer flexibelt för arbetsgivare att anställa och avsluta anställningar och därmed minska riskerna med att anställa. Bland annat bytte allmän visstidOn June 30, 2022, a comprehensive amendment to the Employment Protec-tion Act (1982:80) came into effect. The changes aimed to make it easier for employees to enter and secure employment in the labor market, as well as to simplify and provide more flexibility for employers in hiring and terminating employment, thereby reducing the risks associated with hiring. Amongst other changes "general f