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BACKGROUND: Global longitudinal strain (GLS) and left atrial strain metrics, including reservoir (LAr), contraction (LAct), and conduit strain (LAcd), have emerged as key indicators of left ventricular (LV) function and filling pressures. However, the prognostic value of these markers for risk stratification in acute heart failure (HF) remains uncertain, particularly in identifying patients at ele
Background: In addition to impairing the lung function, chronic obstructive pulmonary disease (COPD) also affects phonatory characteristics. Recent research highlights the potential of voice as a digital biomarker to support clinical decision-making. While machine learning (ML) can detect disease patterns from acoustic features, clinical relevance requires understanding the relationship between th
People with intellectual disabilities have an increased risk of diabetes mellitus (DM). They tend to develop it at earlier ages than the general population, resulting in even higher risks in younger people. However, few studies have separated Type 1 and Type 2 DM. The aim of this study was to assess prevalence of different types of DM in different age groups in relation to the general population.
Background: Metformin is one of the most used drugs worldwide. Given the increasing use of proteomics in trials, bioresources, and clinics, it is crucial to understand the influence of metformin on the levels of the circulating proteome. Methods: We analysed a combined longitudinal proteomics dataset from the IMPOCT, RAMP and S3WP-T2D clinical trials in 98 participants before and after metformin e
BACKGROUND: n-3 (ω-3) long-chain polyunsaturated fatty acids (n-3 LCPUFAs) have anti-inflammatory effects that may influence immune-mediated diseases.OBJECTIVES: We investigated whether higher maternal pregnancy intake of n-3 LCPUFA is associated with a lower incidence of infection in young children.METHODS: We used data from 3 Nordic cohorts: the Norwegian Mother, Father and Child Cohort study (M
Objective To delineate organ-specific and systemic drivers of metabolic dysfunction-associated steatotic liver disease (MASLD), we applied integrative causal inference across clinical, imaging, and proteomic domains in individuals with and without type 2 diabetes (T2D). Methods Bayesian network analyses and complementary two-sample Mendelian randomization were used to quantify causal pathways link
BACKGROUND: Several studies have sought to investigate gambling craving and its potential contribution to gambling problems. One aim of this line of research has been to further examine whether craving should be considered a separate diagnostic criterion for gambling disorder, which it currently is not. The present study aimed to investigate the relationship between craving and other risk factors—
Background: Heart diseases are among the leading causes of disease burden worldwide with often a large impact on the lives of the affected individuals. The association between heart disease and depression is well-known and elevated suicide risk has been demonstrated in several types of heart disease. The aim of this study was to investigate what health care contacts individuals with heart disease
HVAC systems have the purpose of improving indoor air quality in buildings to enhance appropriate occupants- comfort, health and good productivity. Window airing may be one measure to consider in the absence of occupant control of the ventilation and by that, we mean occupants opening windows and doors. Approximating the volume of air exchanged during window airing is important in understanding th
Taurine, an amino sulfonic acid abundant in seafood and meat, has been proposed to have a potential role in the prevention of metabolic dysfunction-associated steatotic liver disease (MASLD) due to its antioxidant and anti-inflammatory properties. However, the association between dietary taurine intake and MASLD remains unclear in human populations. Also, data on dietary taurine intake among adult
Boreal forests emit terpenoid biogenic volatile organic compounds (BVOCs) that significantly affect atmospheric chemistry. Our understanding of the variation of BVOC species emitted from boreal ecosystems is based on relatively few datasets, especially at the ecosystem-level. We conducted measurements to obtain BVOC flux observations above the boreal forest at the ICOS (Integrated Carbon Observati
Bryophytes constitute a diverse plant group with important roles in ecosystem functioning, in particular in arctic and subarctic environments. As they are physiologically strongly dependent on climatic conditions bryophytes could serve as indicators of ongoing climatic change. Their spores are generally dispersed by wind, and because of contrasting phenologies among species, the composition of the
UNLABELLED: The primary objective of this study was to investigate whether ligand-receptor interactions (LRIs) between IGHG and FCGR gene products are associated with progression to type 1 diabetes (T1D). Using two completed clinical trials (DPT-1 and TN07), we applied next-generation targeted sequencing to genotype IGHG and FCGR genes in a cohort of 1,214 individuals and assessed LRI associations
Climate limits distribution of species and shows considerable regional variability. However, studies relating climate variation to species population growth rates in different climatic zones while accounting for species' ecological traits are scarce. We assessed species population responses to the main climatic constraints at a continental scale by studying how precipitation and temperature at dif
Introduction: Amyloid- and tau-positron emission tomography (PET) are promising modalities for detecting pathological changes associated with Alzheimer’s disease (AD); however, their application is limited. Although the use of cerebrospinal fluid (CSF) biomarkers as alternatives to amyloid-PET and tau-PET has been explored, no in vitro diagnostic-approved or commercial CSF biomarker assays are cur
