Filtyp
Abstract: Food availability sets the stage for incubation behaviour of a female bird and thereby indirectly determines the nest temperature, which in turn affects development and metabolism of avian embryos. Changes in development and metabolism in turn are known to influence offspring’s ability to adjust to environmental changes later in life. However, few studies have investigated the role of in
Aim: Head injury is the most common trauma occurring in syncope. We aimed to assess whether syncope as cause of head-trauma affects short-and long-term prognosis. Methods: From a database retrospective analysis of 97,014 individuals attending Emergency Department (ED), we selected data of patients with traumatic head injury including age, gender, injury mechanism, brain imaging, multiple traumas,
RATIONALE: The alarmin S100A9 has been identified as a potential therapeutic target in myocardial infarction. Short-term S100A9 blockade during the inflammatory phase post-myocardial infarction inhibits systemic and cardiac inflammation and improves cardiac function long term. OBJECTIVE: To evaluate the impact of S100A9 blockade on postischemic cardiac repair. METHODS AND RESULTS: We assessed card
Tjänstearbetare, bland annat kvinnodominerade yrkesgrupper i offentlig välfärdssektor, står för en ökande andel av arbetskonflikter i världen. Därmed blir studier av strejker i offentlig sektor allt mer relevanta för att vidareutveckla förståelser av strejk som maktmedel. En forskningslucka finns särskilt avseende kommunalarbetares arbetsinställelser. Med målsättningen att utforska villkoren för o
Background: User involvement is a requirement of most research funders. There is a growing body of literature exploring the benefits and challenges of user involvement in research, but such studies are scarce in the field of aging and health. Moreover, the majority of such research is qualitative, which limits the generalizability of results. The UserAge panel study will be instrumental in expandi
Flood risk is a great global concern that is not only affecting developing countries, but threatens to undermine sustainable development also in the most affluent advanced liberal democracies. While political inertia is delaying much needed global change, efforts to reduce risk and adapt to a changing climate are growing on more local levels. However, floods tend not to be bounded by geopolitical,
Objective: To examine whether C4d plasma levels correlate with treatment response and C4d kidney deposition in systemic lupus erythematosus (SLE) with lupus nephritis (LN). Methods: C4d plasma levels were analyzed by a unique assay specifically detecting C4d arising from complement activation and C4 plasma levels were quantified with competitive ELISA. SLE patients with LN (71) and active SLE pati
This thesis is focused on two globally prevalent diseases: i) non-alcoholic fatty liver disease (NAFLD) and ii) type 2 diabetes (T2D), with an overall aim of improving prediction and causal inference in the context of these conditions. Our projects were mainly conducted using IMI DIRECT and UK Biobank datasets including multi-omics data, extensive environmental exposures, and biological intermedia
Aim: To investigate the associations between major foods and dietary fibre with subtypes of stroke in a large prospective cohort. Methods and results: We analysed data on 418 329 men and women from nine European countries, with an average of 12.7 years of follow-up. Diet was assessed using validated country-specific questionnaires which asked about habitual intake over the past year, calibrated us
Electrical resistivity tomography (ERT) can be used to monitor the interior of hydropower embankments dams, and thereby detect zones with anomalous material properties and flow induced variation in the resistivity caused by changes in total dissolved solids (TDS) and temperature. Furthermore, monitoring of embankment dams in connection with a substantial change in the reservoir water level can det
Background: Saturated fat (SFA) has consistently been shown to increase liver fat, but the response appears variable at the individual level. Phenotypic and genotypic characteristics have been demonstrated to modify the hypercholesterolemic effect of SFA but it is unclear which characteristics that predict liver fat accumulation in response to a hypercaloric diet high in SFA. Objective: To identif
Objectives: Previous large studies of contrast-induced or post-contrast acute kidney injury (CI-AKI/PC-AKI) have been observational, and mostly retrospective, often with patients undergoing non-enhanced CT as controls. This carries risk of inclusion bias that makes the true incidence of PC-AKI hard to interpret. Our aim was to determine the incidence of PC-AKI in a large, randomly selected cohort,
The pancreas is particularly sensitive to acute cellular stress, but this has been difficult to evaluate using light microscopy. Pancreatic ischaemia associated with deceased organ donation negatively impacts whole-organ and isolated-islet transplantation outcomes. Post-mortem changes have also hampered accurate interpretation of ante-mortem pancreatic pathology. A rigorous histological scoring sy
