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The objective of the present study was to map the mechanism whereby G protein-coupled receptor 30 (GPR30), also called G protein-coupled estrogen receptor (GPER), stimulates extracellular signal-regulated kinase (ERK)1/2 signaling. GPR30 plays important roles in cancer and cardiometabolic regulation. We showed recently that GPR30 forms a plasma membrane complex through its C-terminal type I PSD-95
Background: There is a lack of validated tools to assess potential disease progression and hospitalisation decisions in patients presenting to the emergency department (ED) with a suspected infection. This study aimed to identify suitable blood biomarkers (MR-proADM, PCT, lactate and CRP) or clinical scores (SIRS, SOFA, qSOFA, NEWS and CRB-65) to fulfil this unmet clinical need. Methods: An observ
Background: Older people with intellectual disability have high multimorbidity and poor physical and mental health compared with the general population. Consequently, they have a greater need for health care. Hospital readmissions may be an indicator of the quality of health care. However, so far, only a few studies have investigated this outcome in populations of people with intellectual disabili
BACKGROUND: Hyperthyroidism is known to have a significant impact on quality of life (QoL), at least in the short term. The purpose of the present study was to assess QoL in patients 6-10 years after treatment for Graves' disease (GD) with radioiodine (RAI) compared to those treated with thyroidectomy or antithyroid drugs (ATD) as assessed with both thyroid-specific Thyroid-Related Patient-Reporte
IMPORTANCE Prevention of iron deficiency in infancymay promote neurodevelopment. Delayed cord clamping (DCC) can prevent iron deficiency during the first 6 months of life. However, no data are available on long-term effects on infant outcomes in relation to time for umbilical cord clamping. OBJECTIVE To investigate effects of DCC, as compared with early cord clamping (ECC), on infant iron status a
Coastal flooding and erosion are worldwide problems that are further aggravated by rising sea levels and increasing population densities in coastal areas. In many of those areas, sandy beaches and dunes protect thehinterland from waves and extreme water levels during storms, while providing natural and recreational values. Sandy coasts are dynamic systems. Thus, risk assessments and coastal manage
Purpose: To evaluate the effect of treatment, visual function, and other factors on vision-targeted health-related quality of life (HRQOL) of patients with early glaucoma. Design: Randomized clinical trial. Participants: Two hundred fifty-five patients with newly detected open-angle glaucoma and repeatable early visual field (VF) defects, 50 to 80 years old (66% female). Methods: Patients were ran
The hypothesis of this thesis is that climate models should take structural vegetation changes that operate on interannual to centennial time scales into account in order to simulate climate change in a more realistic manner. To evaluate this hypothesis, a regional Earth System Model (ESM) has been developed, validated and applied over Europe. The model has enabled the identification of a number o
INTRODUCTION: Elevated levels of markers for thrombin activation are associated with plaque echogenicity and degree of stenosis in patients with carotid artery stenosis. The Activated Protein C-Protein C Inhibitor (APC-PCI) complex reflects activation of the Protein C system and is a measure of thrombin generation. The aim of the present study was to examine APC-PCI complex in patients undergoing
AIMS/HYPOTHESIS: The T allele of transcription factor 7-like 2 gene variant, TCF7L2 rs7903146, increases the risk of type 2 diabetes by 40-50%. As TCF7L2 rs7903146 has been associated with diminished incretin effect we investigated whether interaction between dietary intake of carbohydrate, fat, protein or fibre and this variant affects the risk of type 2 diabetes. METHODS: A cohort of 24,799
Background Chronic immune stimulation appears to be associated with lymphoplasmacytic lymphoma (LPL)-Waldenström macroglobulinemia (WM); however, available information is sparse. We conducted, to our knowledge, the most comprehensive study to date to evaluate associations between a personal or family history of many immune-related and/or inflammatory disorders and the subsequent risk of LPL-WM. Me
Background: Genetic polymorphisms associated with common aetiologically complex diseases have recently been identified through genome-wide association studies. Direct-to-consumer genetic testing for such polymorphisms, with provision of absolute genetic risk estimates, is marketed by several commercial companies. Polymorphisms associated with atrial fibrillation (AF) have shown relatively large r
Skogar har en positiv inverkan på halten av växthusgaser i atmosfären eftersom de binder koldioxid via fotsyntesen och lagrar kol i marken. Dessutom utgör många skogar en betydande sänka för växthusgasen metan. Upptaget av metan sker i väl syresatta marker genom oxidation utförd av metanotrofa bakterier. Däremot sker en nettoproduktion av metan i syrefattiga skogsmarker när mikroorganismer, s.k. aPopular Abstract in English Forests have a positive impact on the level of greenhouse gases in the atmosphere because they absorb carbon dioxide through photosynthesis and store carbon in the soil. Moreover, many forests function as a sink for the greenhouse gas methane (CH4). The uptake of CH4 takes place in well-aerated soils through oxidation by methanotrophic bacteria. However, there is a net
In addition to being a key criterion of the sustainable development proviso, for business, the integration of social- and ecological considerations into decision-making is of growing importance for minimising future environmentally-related risk and associated economic costs, as well as gaining a share in growing markets favouring products and companies focusing upon social responsibility and ecolo
Syftet med detta Forska och Väx-projekt har varit att öka konkurrenskraften för InView AB genom att tillsammans med forskare bedriva användarcentrerad utveckling av tjänster på ippi-systemet i fyra olika kommuner med lokala behov. Projektet har genomförts med mål att ta fram ett tjänsteutbud som svarar upp till kommunens behov av en ny plattform för hållbar och kvalitetssäkrad kommunikation i äldr
Signs of Flesh: Institution and Body in Accounts of Paranoia (Notes on Schreber and Fabian) As the call for paper to this conference aptly states, phenomenology holds that "[c]onsciousness [is] dependent on a body and a world, which bestow it with existence and meaning." My take on this phenomenologist axiom would be to suggest a complementary thesis, something like: "The world (understood as the
BACKGROUND AND AIM: Many multilevel logistic regression analyses of "neighbourhood and health" focus on interpreting measures of associations (e.g., odds ratio, OR). In contrast, multilevel analysis of variance is rarely considered. We propose an original stepwise analytical approach that distinguishes between "specific" (measures of association) and "general" (measures of variance) contextual eff
