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BACKGROUND: The filaggrin protein is important for skin barrier structure and function. Loss-of-function (null) mutations in the filaggrin gene FLG may increase dermal absorption of chemicals. OBJECTIVE: The objective of the study was to clarify if dermal absorption of chemicals differs depending on FLG genotype. METHOD: We performed a quantitative real-time polymerase chain reaction (qPCR)-based
Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to
Vår tillgång till information om vilka kemiska ämnen som florerar i samhället är relativt bristfällig och följande utredning strävar efter att finna förslag på förbättrande åtgärder. För att skapa en bra utgångspunkt ska den EU-rättsliga regleringen av kemikalier och information sammanfattas och sedan analyseras. I fokus är främst ekodesigndirektivet, REACH-förordningen samt produktdirektiven RoHSOur access to information on which chemicals now prevailing the society is relatively insufficient and the following investigation endeavor to find a suggestion on how to improve the current situation. This essay is an attempt to summarize the regulation of chemicals and information within the EU. Focus is on the Ecodesign Directive, REACH as well as RoHS and WEEE. Main purpose is to investigate w
Populärvetenskaplig sammanfattning: Naturbetesmarker är en av de miljöer som håller den hösta biologiska mångfalden i Sverige (Ingelög et al., 1993). Idag finns endast 10-12 % naturbetesmarker kvar (Jordbruksverket 2005a) av de 2 miljoner hektar som fanns i Sverige på mitten av 1800-talet (WWF, 2006). Naturbetesmarkerna innehar en speciell flora som är anpassad för kontinuerlig störning och näringSemi-natural grasslands are one of the habitats with the highest biodiversity in northern Europe. The high biodiversity is a result of the land being short in nutrient and being continuously disturbed, an effect of mowing and clearing of bushes and trees. Because the development of agriculture into more effective land use, many of these sites and their associated species are endangered. Besides de
Many of the water bodies in Europe are in bad ecological condition due to anthropologic impacts. Pollution and morphological changes have had a severe impact of the water environment and flora and fauna associated with such environments. The fact that water courses often cross administrative borders within countries as well as internationally makes the water management that much more difficult. Th
Detta arbete behandlar medgivandeutredningen (senare benämnd utredningen) av familjehem ur ett rättssäkerhetsperspektiv. Utredningar av familjehem görs utifrån bestämmelser i Socialtjänstlagen (SoL) och det är denna lag som utgör grunden för utredningarna. I arbetet görs därför först en beskrivning och kort genomgång av vad som historiskt föregått den lagstiftning som resulterat i SoL och den ramlThe investigation of the foster home – a study of the rule of law and the best interest of the child This essay deals with the investigation of the foster home and the requirements that the Social Services Act (hereafter referred to as SoL) holds for this. The issue is dealt with in the perspective of the rule of law of the requirements in the investigation, and the best interest of the child. T
Abstract Title: To Cross the Line. An Examination of Cross-Boarder Cooperations Authors: Madeleine Albrektson, Karin Henriksson and Malin Sylvén Tutors: Lena Eskilsson and Ola Thufvesson Keywords: Place marketing, destination cooperation, cross-boarder cooperation, driving forces, advantages, culture, coordination Statement of purpose: Our aim is to gain a deeper understanding of how a cross-board
Wet room - demands and rules This paper explains how the legislative system is built concerning wet rooms within the construction industry. Legislation is developed by all involved authorities. The state has created laws and regulations through parliament and government. These laws are used as a foundation for Boverket, who has produced BBR, which specifies the minimum requirements for the propert
Uppsatsen utreder relationen mellan de EU-rättsliga instrumenten tjänstedirektivet och yrkeskvalifikationsdirektivet. Särskilt utreds vad dessa direktiv har för konsekvenser för yrket trafiklärare i svensk rätt. Gemensamt för de båda direktiven är att de främjar den fria rörligheten genom att avlägsna hinder för yrkesverksamma personer som flyttar mellan medlemsstaterna. Detta sker dock på olika s
The wastewater sector provides water sanitation to populations in order to preserve humanhealth and the natural environment. In developed countries, due among others to increasingpressures coming from climate change and population growth, the wastewater treatment isaffected and needs to adapt to such changes. As a result, effluent requirements arebecoming more stringent, nutrients and organic remo
Tilläggsköpeskillingar har kommit att användas allt mer frekvent i förvärvssammanhang. Detta gäller framför allt i fråga om företagsförvärv men finansieringsmodellen används även i andra sammanhang såsom vid förvärv av fastigheter, patent, tjänster och så vidare. En tilläggsköpeskilling går ut på att säljaren får en fast del av ersättningen vid förvärvet medan möjlighet finns till en eller flera yEarn-outs have become more frequently used in acquisitions. This is particularly true in the case of acquisitions of companies. But the funding model is widely used even in other contexts such as the acquisition of property, patents, services and so on. An earn-out is a contract where the seller receives a fixed remuneration of the acquisition at the time of the contract while the possibility exis
BACKGROUND: Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable subtypes and sources of dietary fibre. This study examined the associations of major plant foods, their subtypes and dietary fibre with risk of IHD in the European Prospective Investigation into Cance
Background: Hip and groin problems are common in ice hockey but studies on professional female players are sparse. The available literature describes hip and groin problems by reporting incidence of time-loss injuries and may thereby underestimate the scope of these problems, which are often due to overuse and may not lead to absence from ice hockey participation.Purpose: The purpose of this study
BACKGROUND: The Chronic Kidney Disease in Children Study (CKiD) equation for children and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for adults are recommended serum creatinine (SCr)-based calculations for estimating glomerular filtration rate (GFR). However, these equations, as well as their combination, have limitations, notably the problem of implausible changes in
BackgroundAlterations in levels of circulating micro-RNAs might reflect within organ signaling or subclinical tissue injury that is linked to risk of diabetes and cardiovascular risk. We previously found that serum levels of miR-483-5p is correlated with cardiometabolic risk factors and incidence of cardiometabolic disease in a case–control sample from the populations-based Malmö Diet and Cancer S
A well-functioning arterial system for the transport of oxygen to the cells is essential for human health. The aorta has a key role for the provision of this physiological effect. Disturbances to aortic function can lead to majorsymptoms and even death due to ruptured abdominal aortic aneurysm (AAA). Multiple diseases may exacerbate, or alleviate the symptoms of aortic conditions.This thesis exami
Introduction: Ankle fractures are commonly treated by open reduction and internal fixation with plate and screws. Unplanned return to theatre is common, in many cases to extract prominent osteosynthesis material from the lateral malleolus as swelling subsides. We hypothesised that patients operated with a posterolateral plate placement on the lateral malleolus would have fewer reoperations, and fe
