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Introduction Lynch syndrome (LS) carriers have a 20-46% lifetime risk of colorectal cancer (CRC) due to mismatch repair gene variants. Mesalamine (5-ASA, 5-aminosalicylic acid), used safely in patients with ulcerative colitis, may reduce CRC risk in LS by decreasing microsatellite instability, a key driver of LS-related cancer. This study evaluates 5-ASA's efficacy as a tolerable chemopreventive d

IntroductionThe DESOLINATION project, DEmonstration of concentrated SOLar power coupledwIth advaNced desalination system in the gulf regION, will demonstrate the efficientcoupling of a concentrated solar power (CSP) system to a membrane-based desalinationsystem at real environment. The waste heat from the CSP system will be used to drivethe membrane-based desalination processes. Therefore, the cos

INTRODUCTION: Postural orthostatic tachycardia syndrome (POTS) is a complex disorder with challenging diagnosis and management.METHODS: This cross-sectional, multi-national, web-based physician chart audit described clinical features and management of POTS, offering insights into disease burden and outcomes before and after the COVID-19 pandemic.RESULTS: Physicians (n = 153), primarily cardiologis

Accurate hygrothermal simulations are essential for assessing moisture safety in buildings, particularly under future climate conditions and extreme events. While the impacts of urban microclimates on energy performance, thermal comfort, and health have been extensively studied, their influence on hygrothermal simulations remains underexplored. This study addresses this gap by evaluating the impac

S100A8 plays a critical role in the pathogenesis of several inflammatory diseases and multiple types of cancer. Therefore, targeting the S100A8 function may alleviate the pathogenic process in various diseases. Here, specific single-chain variable fragment (scFv) antibodies targeting recombinant S100A8 (rS100A8) were selected by phage display technique and characterized using cDNA sequencing, immu

Migratory birds have evolved a multitude of physiological and behavioural adaptations to reach their population-specific wintering areas during their first migration. The endogenous program encodes distance, direction and fuelling, and involves species-specific adaptations leading naïve migratory birds along highly diverse routes. While daylength has been extensively studied in relation to the ons

Observational studies suggest that direct contact from healthcare to at-risk relatives may increase genetic counselling (GC) uptake as compared to family-mediated risk disclosure, but randomised controlled trials (RCTs) are lacking. This study assessed whether the offer of direct letters to relatives at risk of hereditary breast and ovarian cancer (HBOC) or Lynch syndrome increases GC uptake compa

Examining the archaeological material of the modern period, over a period of the last 500 years, this open access book presents a series of case studies that challenges the fallacy of Nordic egalitarianism. The widening gap between rich and poor Western countries is now a well-known phenomenon and, while Scandinavia has often been hailed as one of the regions where inequality has been the lowest,

Denna avhandling breddar rådande förståelser av stipendier och deras systematiska användning inom internationell högre utbildning genom att introducera en ny uppsättning teoretiska verktyg för att undersöka sådana satsningar. Med fokus på organisationer i Mexiko och Indonesien samt de studenter de sponsrade till svenska masterprogram mellan 2013 och 2020, utforskar studien värderingsprocesser, sam

Pulmonary arterial hypertension (PAH) is a life-threatening condition with no cure, making research into its underlying mechanisms critical. The platelet-derived growth factor (PDGF) signaling pathway plays a crucial role in vascular remodeling, a key factor in PAH progression. Anti-PDGF receptor therapies, such as imatinib, show promise but are associated with significant side effects. Recent res

AIMS: Vascular atherosclerotic calcification is a pathological process marked by the abnormal deposition of calcium minerals in the intima. Asporin (ASPN) is a small leucine-rich proteoglycan which interacts with collagen and calcium. Due to its role in matrix mineralization, we hypothesized that ASPN might act as a regulator of vascular calcification, thereby promoting atherosclerotic plaque stab

Purpose: The study aimed to investigate the associations between impaired spirometry such as obstructive pattern and preserved ratio impaired spirometry (PRISm) and occurrent cardiovascular events and deaths in patients with acute myocardial infarction. Patients and Methods: Cohort study of 517 patients with age ≥40 years and ≥10 pack-years of smoking, hospitalized for myocardial infarction at eig

Background: Polygenic risk scores (PRSs) strongly discriminate for prostate cancer risk at the population level. The role of these genetic scores in determining prostate cancer survival is unclear, potentially due to methodological issues. Methods: We included 19,607 men from the Malmö Diet and Cancer Study (MDCS) and the Health Professionals Follow-up Study (HPFS) and analyzed 20-year incidence a

Russia’s full-scale invasion of Ukraine in February 2022 produced one of the largest displacement movements in contemporary Europe, with millions of Ukrainians seeking protection across the European Union. While migration from Ukraine has often been understood through the lenses of safety, protection, and humanitarian need, wartime mobility can also become morally charged. Decisions to leave, stay