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A low glycaemic diet improves oral glucose tolerance but has no effect on β-cell function in C57BL/6J mice.

AIM: Clinical studies have suggested a role for dietary glycaemic index (GI) in body weight regulation and diabetes risk. Here, we investigated the long-term metabolic effects of low and high glycaemic diets using the C57BL/6J mouse model. METHODS: Female C57BL/6J mice were fed low or high glycaemic starch in either low-fat or medium-fat diets for 22 weeks. Oral and intravenous glucose tolerance t

Increased registration of hypertension and cancer diagnoses after the introduction of a new reimbursement system

Objective. To investigate the impact on ICD coding behaviour of a new case-mix reimbursement system based on coded patient diagnoses. The main hypothesis was that after the introduction of the new system the coding of chronic diseases like hypertension and cancer would increase and the variance in propensity for coding would decrease on both physician and health care centre (HCC) levels. Design. C

Real world data on primary treatment for mantle cell lymphoma: a Nordic Lymphoma Group observational study.

There is consensus that young patients with mantle cell lymphoma (MCL) should receive intensive immunochemotherapy regimens, but optimal treatment of elderly patients as well for as patients with limited or indolent disease is not defined. Our aim was to evaluate and compare outcome in relation to prognostic factors and first-line treatment in patients with MCL in a population-based data set. Data

Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding

Aims/hypothesis The association between low birthweight (LBW) and risk of developing type 2 diabetes may involve epigenetic mechanisms, with skeletal muscle being a prime target tissue. Differential DNA methylation patterns have been observed in single genes in muscle tissue from type 2 diabetic and LBW individuals, and we recently showed multiple DNA methylation changes during short-term high-fat

Dimethylglycine Deficiency and the Development of Diabetes mellitus.

Experimental studies have suggested possible protective effects of dimethylglycine (DMG) on glucose metabolism. DMG is degraded to glycine through a DMG-dehydrogenase (DMGDH)-catalyzed reaction and this is the only known pathway for the breakdown of DMG in mammals. In this study we aimed to identify the strongest genetic determinant of circulating DMG concentration and to investigate its associati

Effect of Common Genetic Variants Associated with Type 2 Diabetes and Glycemic Traits on α- and β-cell Function and Insulin Action in Man.

Although meta-analyses of genome-wide association studies have identified more than 60 single nucleotide polymorphisms (SNPs) associated with type 2 diabetes and/or glycemic traits, there is little information whether these variants also affect α-cell function. The aim of the present study was to evaluate the effects of glycemia-associated genetic loci on islet function in vivo and in vitro. We st

Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment.

Diabetes is not a single homogeneous disease but composed of many diseases with hyperglycaemia as a common feature. Four factors have, historically, been used to identify this diversity: the age at onset; the severity of the disease, i.e. degree of loss of beta cell function; the degree of insulin resistance and the presence of diabetes-associated autoantibodies. Our broad understanding of the dis

The comparison of thermal properties of protective clothing using dry and sweating manikins

The thermal insulation of clothing is commonly determined by dry thermal manikins either made of plastic or metal. For the determination of evaporative resistance of clothing ensemble, there exist three types of manikin methods: pre-wetted underwear or “skin” covered on dry manikins, the manikin with regulated constant water supply to the “skin” surface and the sweating fabric manikin based on a w

Carbon dioxide exchange of buds and developing shoots of boreal Norway spruce exposed to elevated or ambient CO2 concentration and temperature in whole-tree chambers

Effects of ambient and elevated temperature and atmospheric carbon dioxide concentration ([CO2]) on CO2 assimilation rate and the structural and phenological development of shoots during their first growing season were studied in 45-year-old Norway spruce trees (Picea abies (L.) Karst.) enclosed in whole-tree chambers. Continuous measurements of net assimilation rate (NAR) in individual buds and s

Employing validation and verification tests as an integral part of evacuation model development.

The definition of Validation and Verification (V&V) tests for analysing evacuation model capabilities is the object of a large debate among researchers given the lack of an international standard. Four main types of tests have been reported in the literature, 1) component testing, 2) functional verification, 3) qualitative verification and 4) quantitative validation. An important issue relates

Copyright Protection of Software under the TRIPS Agreement - Software reengineering and reverse engineering in the context of international trade law

In 1994, the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) was adopted as part of the Agreement Establishing the World Trade Organization (WTO). Pursuant to the TRIPS Agreement copyright protection of computer programs for the first time had received explicit recognition on the international level. Despite obligating all WTO Members to protect computer programs as lite

Simulated mechanisms of soil N feedback on the forest CO2 response

An improved understanding of the response of forest ecosystems to elevated levels of CO2 in the atmosphere is crucial because atmospheric CO2 concentration continues to increase at an accelerating rate and forests are an important sink in the global carbon cycle. Several CO2-enrichment experiments have now been running for more than 10 years, with highly variable short-term results after the first

Urban Squares, Spatio-temporal studies of design and everyday life in the Öresund region

Urban Squares suggests a specific and fresh take on agorology – the study of urban squares. The approach is one of recording everyday life and focusing on different ways to describe and investigate the public life and space of urban squares. The book comprises four empirical case studies of squares focusing especially on the urban material culture and spatio-temporal changes of these squares. The

Varför certifieringar? En marknadsföringsmässig undersökning kring syftet med certifieringar

Corporate social responsibility, also known as CSR, is the responsibility companies have regarding its societal impact within the area in which they operate. Companies often choose to market their social responsibility which results in increased consumer loyalty and thus an increased competitive advantage. To communicate their CSR initiatives, companies may use various certifications such as MSC a

Market interpretation of reported currency effects on revenue in quarterly financial statements: reporting opaqueness, investor attention and market efficiency implications

Seminar date: 2021-06-03 Course: BUSN79 - Degree Project in Accounting and Finance Authors: Tobias Scheufele and Sebastian Hofstedt Supervisor: Håkan Jankensgård Examiner: Marco Bianco Key words: currency effects on revenue, investor attention, market efficiency, portfolio strategies, alpha Purpose: investigate the relationship between reported currency growth on revenue and subsequent stock

Hållbarhet mvh. Fast Fashion: En kvalitativ studie om konsumenters tolkning av miljömässig hållbarhetskommunikation

Examensarbetets titel: Hållbarhet mvh. Fast Fashion Seminariedatum: 2021 - 06 - 02 Ämne/kurs: FEKH29, Examensarbete kandidatnivå i företagsekonomi, 15 högskolepoäng Författare: Gröndahl, Elias. Lantz, Mikael. Ramquist, Linnéa. Handledare: Annette Cerne Fem nyckelord: konsumentattityd, hållbarhet, kommunikation, fast fashion, legitimitet Forskningsfråga: Hur tolkar svenska konsumenter fast fashion-Title: Sustainability b.r Fast Fashion Seminar date: 2021 - 06 - 02 Course: FEKH29, Degree Project Undergraduate level, Business Administration, Undergraduate level, 15 University Credits Points (UPC) or ECTS‐cr) Authors: Gröndahl, Elias. Lantz, Mikael. Ramquist, Linnéa. Advisor: Annette Cerne Key words: consumer attitudes, sustainability, communication, fast fashion, legitimacy Research question: