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Challenges the terrestrial focus of European prehistory, emphasizing the significance of seascapes, maritime networks, and coastal societies in shaping prehistoric Europe.For many years now, the main thrust of European prehistory has followed a fundamentally terrestrial plot line. This terrestrial paradigm has undervalued the story of Europe as a peninsula between the Baltic, Mediterranean and Atl
OBJECTIVES: Esophageal cancer is a highly fatal malignant neoplasm, with 2 etiologically different histological types. A large prospective study is expected to elucidate the specific risk of the 90% subtype of esophageal cancer, esophageal squamous cell carcinoma (ESCC), with metformin therapy. This study aims to determine the association between metformin use and incident ESCC risk.METHODS: This
Emotional communication, especially through social media platforms, has become a contemporary populist threat. While this phenomenon has been studied in for example news media and social movements, we know less about its influence on civil society organizations, despite their pluralism being a centerpiece in a vibrant democracy. More specifically, we do not know if social media make civil society
Background: Previous studies on causative pathogens in peritonsillar abscesses have yielded varying results. However, Group A streptococci (GAS) and Fusobacterium necrophorum have been identified frequently. The aim of this study was to investigate pathogens in peritonsillar abscesses in patients tested for both ß-hemolytic streptococci and F. necrophorum, and to investigate associations between p
BACKGROUND: The discovery that heterozygous missense mutations in the gene encoding triggering receptor expressed on myeloid cells 2 (TREM2) are risk factors for Alzheimer's disease (AD), with only the apolipoprotein E (APOE) ε4 gene allele conferring a higher risk, has led to increased interest in immune biology in the brain. TREM2 is expressed on microglia, the resident immune cells of the brain
BACKGROUND AND PURPOSE—: Patient selection in clinical trials on intracerebral hemorrhage (ICH) affects overall applicability of results. We estimated eligibility for completed, ongoing, and planned clinical trials in an unselected cohort of patients with ICH. METHODS—: Large clinical ICH trials were identified using trial registration databases. Each trial’s inclusion criteria were applied to a c
Early psychosocial adversities and maladjustment, such as childhood maltreatment and school adjustment problems, have been linked to an increased risk of aggressive antisocial behaviors. Yet, clinical studies of subjects at the highest risk of persistence in such behaviors are rare, especially during the life-changing transition years of emerging adulthood. This study describes early predictors of
Rules and guidelines on food safety and ethical aspects of production, such as animal welfare and labour conditions, have traditionally been a matter of national legislation. However, in recent years, powerful retailers and food processors have started to impose requirements on downstream producers through private standards. Since private standards are used by private actors and not by states, the
OBJECTIVE To investigate the efficacy and safety of liraglutide added to capped insulin doses in subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS A 26-week, placebo-controlled, double-blind, parallel-group trial enrolling 835 subjects randomized 3:1 receiving once-daily subcutaneous liraglutide (1.8, 1.2, and 0.6 mg) or placebo added to an individually capped total daily dose of insulin.
Objective:: The loss of a parent to cancer is considered one of the most traumatic events a teenager can experience. Studies have shown that teenagers, from the time of diagnosis, are already extremely worried about the consequences of a parent's cancer but tend to be left to manage these concerns on their own. The present study aimed to explore young adults' advice to healthcare professionals on
Latent autoimmune diabetes of the adults (LADA) accounts for up to 12% of all patients with diabetes. Initially the disease resembles type 2 diabetes (T2D); however, the typical presence of β cell autoantibodies indicates an autoimmune basis of LADA. While dysfunctional regulatory T cells (Tregs) have been implicated in autoimmune diabetes, these cells have been scarcely studied in LADA. The aim o
Objective: To test whether plasma tau is altered in Alzheimer disease (AD) and whether it is related to changes in cognition, CSF biomarkers of AD pathology (including β-amyloid [Aβ] and tau), brain atrophy, and brain metabolism. Methods: This was a study of plasma tau in prospectively followed patients with AD (n 179), patients with mild cognitive impairment (n 195), and cognitive healthy control
Background: Mild traumatic brain injury (TBI) is associated with substantial costs due to over-triage of patients to computed tomography (CT) scanning, despite validated decision rules. Serum biomarker S100B has shown promise for safely omitting CT scans but the economic impact from clinical use has never been reported. In 2007, S100B was adapted into the existing Scandinavian management guideline
Autosomal recessive congenital ichthyosis (ARCI) represents a heterogeneous group of rare disorders of coz1rnification with 3 major subtypes: harlequin ichthyosis (HI), lamellar ichthyosis (LI) and congenital ichthyosiform erythroderma (CIE). A 4th subtype has also been proposed: pleomorphic ichthyosis (PI), characterized by marked skin changes at birth and subsequently mild symptoms. In nationwid
Context: We have previously found that visceral fat is a stronger predictor for cardiovascular risk factors than body mass index (BMI). Objective: This study sought to investigate the prevalence of diabetes in elderly men and women in relation to objectively assessed visceral fat volume. Design and Setting: The cohort consisted of a population-based sample of 705 men and 688 women, all age 70 y at
